ENSMUSG00000044244


Mus musculus

Features
Gene ID: ENSMUSG00000044244
  
Biological name :Il20rb
  
Synonyms : Il20rb / interleukin 20 receptor subunit beta
  
Possible biological names infered from orthology : Q6UXL0
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: E3.3
Gene start: 100457719
Gene end: 100486788
  
Corresponding Affymetrix probe sets: 10596027 (MoGene1.0st)   10596034 (MoGene1.0st)   10596041 (MoGene1.0st)   1437876_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000096057
NCBI entrez gene - 213208     See in Manteia.
MGI - MGI:2143266
RefSeq - NM_001033543
RefSeq Peptide - NP_001028715
swissprot - E9Q9A6
Ensembl - ENSMUSG00000044244
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 crfb16ENSDARG00000075181Danio rerio
 IL20RBENSGALG00000013169Gallus gallus
 IL20RBENSG00000174564Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR015373  Interferon/interleukin receptor domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001808 negative regulation of type IV hypersensitivity IMP
 biological_processGO:0002437 inflammatory response to antigenic stimulus IMP
 biological_processGO:0002765 immune response-inhibiting signal transduction IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0032689 negative regulation of interferon-gamma production IMP
 biological_processGO:0032703 negative regulation of interleukin-2 production IMP
 biological_processGO:0032733 positive regulation of interleukin-10 production IMP
 biological_processGO:0032753 positive regulation of interleukin-4 production IMP
 biological_processGO:0042130 negative regulation of T cell proliferation IMP
 biological_processGO:0048873 homeostasis of number of cells within a tissue IMP
 biological_processGO:0050863 regulation of T cell activation IMP
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 molecular_functionGO:0004920 interleukin-10 receptor activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042015 interleukin-20 binding IPI


Pathways (from Reactome)
Pathway description
Interleukin-20 family signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Taglntm1Liw/Taglntm1Liw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ophn1tm1Bill/Y
Genetic Background: Not Specified

 MP:0004931 enlarged epididymis "increase in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0005617 increased susceptibility to type IV hypersensitivity reaction "greater likelihood of developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020007 Il20ra / Q6PHB0 / interleukin 20 receptor, alpha / Q9UHF4* / interleukin 20 receptor subunit alpha*  / complex
 ENSMUSG00000016524 Il19 / Q8CJ70 / Interleukin-19 / Q9UHD0*  / complex
 ENSMUSG00000026416 Il20 / Q9JKV9 / interleukin 20 / Q9NYY1*  / complex
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex
 ENSMUSG00000037157 Q80XZ4 / Il22ra1 / Interleukin-22 receptor subunit alpha-1 / Q8N6P7*  / complex
 ENSMUSG00000026420 Il24 / interleukin 24 / Q13007*  / complex






 

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