| MP:0008537 | increased susceptibility to induced colitis | "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm1Tyj/Rb1+,Smarca4tm1Mag/Smarca4+
Genetic Background: involves: 129S/Sv * 129S2/SvPas * C57BL/6J * CD-1
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| MP:0008560 | increased tumor necrosis factor secretion | "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
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Allelic Composition: Rb1tm1Tyj/Rb1+,Smarca4tm1Mag/Smarca4+
Genetic Background: involves: 129S/Sv * 129S2/SvPas * C57BL/6J * CD-1
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| MP:0008566 | increased interferon-gamma secretion | "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893] |
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Allelic Composition: Rb1tm1Tyj/Rb1+,Smarca4tm1Mag/Smarca4+
Genetic Background: involves: 129S/Sv * 129S2/SvPas * C57BL/6J * CD-1
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| MP:0008657 | increased interleukin-1 beta secretion | "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600] |
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Allelic Composition: Rb1tm1Tyj/Rb1+,Smarca4tm1Mag/Smarca4+
Genetic Background: involves: 129S/Sv * 129S2/SvPas * C57BL/6J * CD-1
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| MP:0008661 | decreased interleukin-10 secretion | "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510] |
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Allelic Composition: Rb1tm1Tyj/Rb1+,Smarca4tm1Mag/Smarca4+
Genetic Background: involves: 129S/Sv * 129S2/SvPas * C57BL/6J * CD-1
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| MP:0008663 | increased interleukin-12 secretion | "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512] |
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Allelic Composition: Rb1tm1Tyj/Rb1+,Smarca4tm1Mag/Smarca4+
Genetic Background: involves: 129S/Sv * 129S2/SvPas * C57BL/6J * CD-1
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| MP:0008673 | decreased interleukin-13 secretion | "reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513] |
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Allelic Composition: Rb1tm1Tyj/Rb1+,Smarca4tm1Mag/Smarca4+
Genetic Background: involves: 129S/Sv * 129S2/SvPas * C57BL/6J * CD-1
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| MP:0008705 | increased interleukin-6 secretion | "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
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Allelic Composition: Rb1tm1Tyj/Rb1+,Smarca4tm1Mag/Smarca4+
Genetic Background: involves: 129S/Sv * 129S2/SvPas * C57BL/6J * CD-1
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| MP:0008706 | decreased interleukin-6 secretion | "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
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Allelic Composition: Rb1tm1Tyj/Rb1+,Smarca4tm1Mag/Smarca4+
Genetic Background: involves: 129S/Sv * 129S2/SvPas * C57BL/6J * CD-1
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| MP:0010180 | increased susceptibility to weight loss | "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Rb1tm1Tyj/Rb1+,Smarca4tm1Mag/Smarca4+
Genetic Background: involves: 129S/Sv * 129S2/SvPas * C57BL/6J * CD-1
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| MP:0013298 | increased susceptibility to colitis induced morbidity/mortality | " increased likelihood that an organism will display the expected moribund state caused by colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:Annie_Speak] |
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Allelic Composition: Rb1tm1Tyj/Rb1+,Smarca4tm1Mag/Smarca4+
Genetic Background: involves: 129S/Sv * 129S2/SvPas * C57BL/6J * CD-1
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| MP:0013956 | decreased colon length | "reduced length of the portion of the large intestine between the cecum and the rectum" [ISBN:0683400088] |
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Allelic Composition: Rb1tm1Tyj/Rb1+,Smarca4tm1Mag/Smarca4+
Genetic Background: involves: 129S/Sv * 129S2/SvPas * C57BL/6J * CD-1
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