ENSMUSG00000037157


Mus musculus

Features
Gene ID: ENSMUSG00000037157
  
Biological name :Il22ra1
  
Synonyms : Il22ra1 / Interleukin-22 receptor subunit alpha-1 / Q80XZ4
  
Possible biological names infered from orthology : Q8N6P7
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D3
Gene start: 135728172
Gene end: 135752140
  
Corresponding Affymetrix probe sets: 10509063 (MoGene1.0st)   1445457_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099605
NCBI entrez gene - 230828     See in Manteia.
MGI - MGI:2663588
RefSeq - NM_178257
RefSeq Peptide - NP_839988
swissprot - Q80XZ4
Ensembl - ENSMUSG00000037157
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ifnlr1ENSDARG00000087131Danio rerio
 ENSGALG00000004221Gallus gallus
 Q8N6P7ENSG00000142677Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Il20ra / Q6PHB0 / interleukin 20 receptor, alpha / Q9UHF4* / interleukin 20 receptor subunit alpha*ENSMUSG0000002000714
Q80XF5 / Il22ra2 / Interleukin-22 receptor subunit alpha-2 / Q969J5*ENSMUSG0000003976012


Protein motifs (from Interpro)
Interpro ID Name
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR015373  Interferon/interleukin receptor domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0050829 defense response to Gram-negative bacterium IMP
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 molecular_functionGO:0004896 cytokine receptor activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042015 interleukin-20 binding IPI


Pathways (from Reactome)
Pathway description
Interleukin-20 family signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1Cgn,Il20ratm1Rsab/Il20ratm1Rsab,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1Cgn,Il20ratm1Rsab/Il20ratm1Rsab,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ikbkbtm1Cgn/Ikbkbtm1Cgn,Il22ra1tm1Rsab/Il22ra1tm1Rsab,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026416 Il20 / Q9JKV9 / interleukin 20 / Q9NYY1*  / complex
 ENSMUSG00000074695 Il22 / Q9JJY9 / Interleukin-22 / Q9GZX6*  / reaction / complex
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / reaction / complex
 ENSMUSG00000044244 Il20rb / interleukin 20 receptor subunit beta / Q6UXL0*  / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / reaction / complex
 ENSMUSG00000026420 Il24 / interleukin 24 / Q13007*  / complex
 ENSMUSG00000090461 Q9JJY8 / Iltifb / Interleukin-22b / IL22* / Q9GZX6* / interleukin 22*  / reaction / complex






 

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