ENSG00000127318


Homo sapiens

Features
Gene ID: ENSG00000127318
  
Biological name :IL22
  
Synonyms : IL22 / interleukin 22 / Q9GZX6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q15
Gene start: 68248242
Gene end: 68253607
  
Corresponding Affymetrix probe sets: 221165_s_at (Human Genome U133 Plus 2.0 Array)   222974_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000442424
Ensembl peptide - ENSP00000329384
NCBI entrez gene - 50616     See in Manteia.
OMIM - 605330
RefSeq - NM_020525
RefSeq Peptide - NP_065386
swissprot - Q9GZX6
Ensembl - ENSG00000127318
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL22ENSGALG00000009904Gallus gallus
 Il22ENSMUSG00000074695Mus musculus
 IltifbENSMUSG00000090461Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009079  Four-helical cytokine-like, core
 IPR020423  Interleukin-10, conserved site
 IPR020453  Interleukin-22


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006953 acute-phase response NAS
 biological_processGO:0006954 inflammatory response NAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0051384 response to glucocorticoid IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0045518 interleukin-22 receptor binding NAS


Pathways (from Reactome)
Pathway description
Interleukin-20 family signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105397 TYK2 / P29597 / tyrosine kinase 2  / reaction / complex
 ENSG00000168610 STAT3 / P40763 / signal transducer and activator of transcription 3  / complex
 ENSG00000142677 Q8N6P7 / IL22RA1 / interleukin 22 receptor subunit alpha 1  / complex / reaction
 ENSG00000243646 IL10RB / Q08334 / interleukin 10 receptor subunit beta  / reaction / complex
 ENSG00000164485 Q969J5 / IL22RA2 / interleukin 22 receptor subunit alpha 2  / complex / reaction
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / reaction / complex
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / reaction / complex






 

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