ENSMUSG00000062157


Mus musculus

Features
Gene ID: ENSMUSG00000062157
  
Biological name :Ifnlr1
  
Synonyms : Ifnlr1 / Interferon lambda receptor 1 / Q8CGK5
  
Possible biological names infered from orthology : Q8IU57
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D3
Gene start: 135686287
Gene end: 135708181
  
Corresponding Affymetrix probe sets: 10509053 (MoGene1.0st)   1460598_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000074009
NCBI entrez gene - 242700     See in Manteia.
MGI - MGI:2429859
RefSeq - NM_174851
RefSeq Peptide - NP_777276
swissprot - Q3URN4
swissprot - Q8CGK5
Ensembl - ENSMUSG00000062157
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 K9JA28ENSGALG00000004231Gallus gallus
 IFNLR1ENSG00000185436Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002385 mucosal immune response IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0034342 response to type III interferon ISS
 biological_processGO:0050691 regulation of defense response to virus by host IEA
 biological_processGO:0051607 defense response to virus IGI
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0032002 interleukin-28 receptor complex ISO
 molecular_functionGO:0004896 cytokine receptor activity IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-20 family signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001793 altered susceptibility to infection "a change in the likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Afg3l2Emv66/Afg3l2Emv66
Genetic Background: FVB.MEV2-Afg3l2Emv66

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0008347 decreased gamma-delta T cell number "reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0010169 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
Show

Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0012765 decreased alpha-beta T cell number "reduced number of T cells that expresses an alpha-beta T cell receptor complex" [CL:0000789]
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Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / complex
 ENSMUSG00000060747 Ifnl3 / Q8CGK6 / Interferon lambda-3 / IFNL2* / Q8IZI9* / Q8IZJ0* / interferon lambda 2*  / complex
 ENSMUSG00000059128 Ifnl2 / Q4VK74 / Interferon lambda-2 / IFNL3* / Q8IZJ0* / Q8IZI9* / interferon lambda 3*  / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex / reaction






 

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