ENSMUSG00000040663


Mus musculus

Features
Gene ID: ENSMUSG00000040663
  
Biological name :Clcf1
  
Synonyms : Cardiotrophin-like cytokine factor 1 / Clcf1 / Q9QZM3
  
Possible biological names infered from orthology : Q9UBD9
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 4214238
Gene end: 4223490
  
Corresponding Affymetrix probe sets: 10460385 (MoGene1.0st)   1437270_a_at (Mouse Genome 430 2.0 Array)   1437271_at (Mouse Genome 430 2.0 Array)   1450262_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000045562
Ensembl peptide - ENSMUSP00000118157
NCBI entrez gene - 56708     See in Manteia.
MGI - MGI:1930088
RefSeq - NM_001310039
RefSeq - NM_001310038
RefSeq - NM_019952
RefSeq Peptide - NP_001296967
RefSeq Peptide - NP_001296968
RefSeq Peptide - NP_064336
swissprot - Q9QZM3
swissprot - D6RIL9
Ensembl - ENSMUSG00000040663
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 clcf1ENSDARG00000076140Danio rerio
 CLCF1ENSG00000175505Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ctf2 / P83714 / Cardiotrophin-2 ENSMUSG0000006003424


Protein motifs (from Interpro)
Interpro ID Name
 IPR009079  Four-helical cytokine-like, core
 IPR010681  Plethodontid receptivity factor PRF/cardiotrophin-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002639 positive regulation of immunoglobulin production IDA
 biological_processGO:0002830 positive regulation of type 2 immune response NAS
 biological_processGO:0007166 cell surface receptor signaling pathway IDA
 biological_processGO:0007259 JAK-STAT cascade IDA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030183 B cell differentiation IDA
 biological_processGO:0030890 positive regulation of B cell proliferation IDA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0048295 positive regulation of isotype switching to IgE isotypes IDA
 biological_processGO:0048711 positive regulation of astrocyte differentiation IDA
 biological_processGO:0050727 regulation of inflammatory response NAS
 biological_processGO:0051466 positive regulation of corticotropin-releasing hormone secretion TAS
 biological_processGO:0051896 regulation of protein kinase B signaling TAS
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade TAS
 biological_processGO:2000672 negative regulation of motor neuron apoptotic process NAS
 cellular_componentGO:0005576 extracellular region ISS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0097058 CRLF-CLCF1 complex IEA
 cellular_componentGO:0097059 CNTFR-CLCF1 complex IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005125 cytokine activity ISO
 molecular_functionGO:0005127 ciliary neurotrophic factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
IL-6-type cytokine receptor ligand interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000909 abnormal facial motor nucleus morphology "malformation or disorganization of the group of motor neurons residing in the pons that innervate the muscles of facial expression" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Fosl2tm2Wag/Fosl2tm2Wag,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Fosl2tm2Wag/Fosl2tm2Wag,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Fosl2tm2Wag/Fosl2tm2Wag,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001435 no suckling reflex "inability to orient and open/close mouth in sucking pattern in response to external light touching or stroking of the chin" [J:56847]
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Allelic Composition: Fosl2tm2Wag/Fosl2tm2Wag,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Asf1atm1b(KOMP)Wtsi/Asf1a+
Genetic Background: C57BL/6N-Asf1atm1b(KOMP)Wtsi/J

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Fosl2tm2Wag/Fosl2tm2Wag,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Fosl2tm2Wag/Fosl2tm2Wag,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000054263 Lifr / P42703 / Mus musculus leukemia inhibitory factor receptor (Lifr), transcript variant 3, mRNA. / P42702* / LIF receptor alpha*  / complex / reaction
 ENSMUSG00000021756 Il6st / Q00560 / Interleukin-6 receptor subunit beta / P40189* / interleukin 6 signal transducer*  / complex / reaction
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex / reaction
 ENSMUSG00000007888 Crlf1 / Q9JM58 / Cytokine receptor-like factor 1 / O75462*  / reaction / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / reaction / complex
 ENSMUSG00000028444 Cntfr / O88507 / Ciliary neurotrophic factor receptor subunit alpha / P26992* / ciliary neurotrophic factor receptor*  / reaction / complex






 

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