ENSG00000183709


Homo sapiens

Features
Gene ID: ENSG00000183709
  
Biological name :IFNL2
  
Synonyms : IFNL2 / interferon lambda 2 / Q8IZJ0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.2
Gene start: 39268514
Gene end: 39270092
  
Corresponding Affymetrix probe sets: 1552609_s_at (Human Genome U133 Plus 2.0 Array)   1552915_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000333639
NCBI entrez gene - 282616     See in Manteia.
OMIM - 607401
RefSeq - NM_172138
RefSeq Peptide - NP_742150
swissprot - Q8IZJ0
Ensembl - ENSG00000183709
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 B4ER10ENSGALG00000033141Gallus gallus
 Ifnl2ENSMUSG00000059128Mus musculus
 Ifnl3ENSMUSG00000060747Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IFNL3 / Q8IZI9 / interferon lambda 3ENSG0000019711094
IFNL1 / Q8IU54 / interferon lambda 1ENSG0000018239370


Protein motifs (from Interpro)
Interpro ID Name
 IPR029177  Interferon lambda


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002385 mucosal immune response ISS
 biological_processGO:0007259 JAK-STAT cascade IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0050778 positive regulation of immune response IEA
 biological_processGO:0050863 regulation of T cell activation IBA
 biological_processGO:0051607 defense response to virus IBA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005125 cytokine activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-20 family signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105397 TYK2 / P29597 / tyrosine kinase 2  / complex
 ENSG00000243646 IL10RB / Q08334 / interleukin 10 receptor subunit beta  / complex
 ENSG00000185436 IFNLR1 / Q8IU57 / interferon lambda receptor 1  / complex
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / complex






 

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