ENSG00000182393


Homo sapiens

Features
Gene ID: ENSG00000182393
  
Biological name :IFNL1
  
Synonyms : IFNL1 / interferon lambda 1 / Q8IU54
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.2
Gene start: 39296325
Gene end: 39298673
  
Corresponding Affymetrix probe sets: 1552917_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000329991
NCBI entrez gene - 282618     See in Manteia.
OMIM - 607403
RefSeq - NM_172140
RefSeq Peptide - NP_742152
swissprot - Q8IU54
Ensembl - ENSG00000182393
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 B4ER10ENSGALG00000033141Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IFNL3 / Q8IZI9 / interferon lambda 3ENSG0000019711071
IFNL2 / Q8IZJ0 / interferon lambda 2ENSG0000018370970


Protein motifs (from Interpro)
Interpro ID Name
 IPR029177  Interferon lambda


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002829 negative regulation of type 2 immune response IDA
 biological_processGO:0007259 JAK-STAT cascade IEA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0032696 negative regulation of interleukin-13 production IDA
 biological_processGO:0032714 negative regulation of interleukin-5 production IDA
 biological_processGO:0032729 positive regulation of interferon-gamma production IDA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IDA
 biological_processGO:0043381 negative regulation of memory T cell differentiation IDA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045345 positive regulation of MHC class I biosynthetic process IDA
 biological_processGO:0045581 negative regulation of T cell differentiation IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0046427 positive regulation of JAK-STAT cascade IDA
 biological_processGO:0050778 positive regulation of immune response TAS
 biological_processGO:0051607 defense response to virus IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0032002 interleukin-28 receptor complex IDA
 molecular_functionGO:0005102 signaling receptor binding IDA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0032003 interleukin-28 receptor binding IPI


Pathways (from Reactome)
Pathway description
Other interleukin signaling
Interleukin-20 family signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105397 TYK2 / P29597 / tyrosine kinase 2  / complex / reaction
 ENSG00000243646 IL10RB / Q08334 / interleukin 10 receptor subunit beta  / complex / reaction
 ENSG00000185436 IFNLR1 / Q8IU57 / interferon lambda receptor 1  / reaction / complex
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / complex / reaction






 

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