ENSG00000197110


Homo sapiens

Features
Gene ID: ENSG00000197110
  
Biological name :IFNL3
  
Synonyms : IFNL3 / interferon lambda 3 / Q8IZI9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.2
Gene start: 39243553
Gene end: 39245129
  
Corresponding Affymetrix probe sets: 1552609_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000481633
Ensembl peptide - ENSP00000409000
NCBI entrez gene - 282617     See in Manteia.
OMIM - 607402
RefSeq - XM_005258765
RefSeq - NM_172139
RefSeq Peptide - NP_001333866
RefSeq Peptide - NP_742151
swissprot - Q8IZI9
swissprot - A0A0C4DGW8
Ensembl - ENSG00000197110
  
Related genetic diseases (OMIM): 609532 - {Hepatitis C virus infection, response to therapy of}, 609532
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 B4ER10ENSGALG00000033141Gallus gallus
 Ifnl2ENSMUSG00000059128Mus musculus
 Ifnl3ENSMUSG00000060747Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IFNL2 / Q8IZJ0 / interferon lambda 2ENSG0000018370996
IFNL1 / Q8IU54 / interferon lambda 1ENSG0000018239372


Protein motifs (from Interpro)
Interpro ID Name
 IPR029177  Interferon lambda


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007259 JAK-STAT cascade IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0045071 negative regulation of viral genome replication ISS
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0050778 positive regulation of immune response IEA
 biological_processGO:0050863 regulation of T cell activation IBA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IMP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005125 cytokine activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-20 family signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105397 TYK2 / P29597 / tyrosine kinase 2  / complex
 ENSG00000243646 IL10RB / Q08334 / interleukin 10 receptor subunit beta  / complex
 ENSG00000185436 IFNLR1 / Q8IU57 / interferon lambda receptor 1  / complex
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / complex






 

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