ENSGALG00000013867


Gallus gallus

Features
Gene ID: ENSGALG00000013867
  
Biological name :PTPN2
  
Synonyms : protein tyrosine phosphatase, non-receptor type 2 / PTPN2
  
Possible biological names infered from orthology : P17706 / Q06180 / Tyrosine-protein phosphatase non-receptor type 2
  
Species: Gallus gallus
  
Chr. number: 2
Strand: 1
Band:
Gene start: 97231209
Gene end: 97265121
  
Corresponding Affymetrix probe sets: Gga.1107.1.S1_at (Chicken Array)   GgaAffx.24297.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000022449
NCBI entrez gene - 396409     See in Manteia.
RefSeq - NM_001199387
RefSeq - XM_015282452
RefSeq - XM_015282453
RefSeq Peptide - NP_001186316
swissprot - F1NYW0
Ensembl - ENSGALG00000013867
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpn2aENSDARG00000016481Danio rerio
 ptpn2bENSDARG00000035986Danio rerio
 PTPN2ENSG00000175354Homo sapiens
 Ptpn2ENSMUSG00000024539Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTPN1 / tyrosine-protein phosphatase non-receptor type 1 / P18031* / P35821* / protein tyrosine phosphatase, non-receptor type 1*ENSGALG0000000801059
PTPRB / protein tyrosine phosphatase, receptor type B / B2RU80* / P23467*ENSGALG0000001004927
PTPRO / receptor-type tyrosine-protein phosphatase O / E9Q612* / Q16827* / protein tyrosine phosphatase, receptor type O*ENSGALG0000001308526
PTPN9 / tyrosine-protein phosphatase non-receptor type 9 / O35239* / P43378* / protein tyrosine phosphatase, non-receptor type 9*ENSGALG0000000166426
PTPRJ / receptor-type tyrosine-protein phosphatase eta precursor / Q12913* / protein tyrosine phosphatase, receptor type J*ENSGALG0000000638226
PTPN22 / protein tyrosine phosphatase, non-receptor type 22 / P29352* / Q9Y2R2* / Tyrosine-protein phosphatase non-receptor type 22 *ENSGALG0000002165625
PTPRQ / protein tyrosine phosphatase, receptor type Q / P0C5E4* / Phosphatidylinositol phosphatase PTPRQ *ENSGALG0000001093522
ENSGALG0000002135517
P35831* / PTPN12* / Q05209* / protein tyrosine phosphatase, non-receptor type 12*ENSGALG0000004256910
ENSGALG000000005844


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR012265  Protein-tyrosine phosphatase, non-receptor type-1/2
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008286 insulin receptor signaling pathway IEA
 biological_processGO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0010888 negative regulation of lipid storage IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0030183 B cell differentiation IEA
 biological_processGO:0030217 T cell differentiation IEA
 biological_processGO:0030218 erythrocyte differentiation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0042532 negative regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0045650 negative regulation of macrophage differentiation IEA
 biological_processGO:0045722 positive regulation of gluconeogenesis IEA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IEA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0050860 negative regulation of T cell receptor signaling pathway IEA
 biological_processGO:0050922 negative regulation of chemotaxis IEA
 biological_processGO:0060336 negative regulation of interferon-gamma-mediated signaling pathway IEA
 biological_processGO:0060339 negative regulation of type I interferon-mediated signaling pathway IEA
 biological_processGO:0061099 negative regulation of protein tyrosine kinase activity IEA
 biological_processGO:0070104 negative regulation of interleukin-6-mediated signaling pathway IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:1902202 regulation of hepatocyte growth factor receptor signaling pathway IEA
 biological_processGO:1902206 negative regulation of interleukin-2-mediated signaling pathway IEA
 biological_processGO:1902215 negative regulation of interleukin-4-mediated signaling pathway IEA
 biological_processGO:1902227 negative regulation of macrophage colony-stimulating factor signaling pathway IEA
 biological_processGO:1902233 negative regulation of positive thymic T cell selection IEA
 biological_processGO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
 biological_processGO:1903899 positive regulation of PERK-mediated unfolded protein response IEA
 biological_processGO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019905 syntaxin binding IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA
 molecular_functionGO:0097677 STAT family protein binding IEA


Pathways (from Reactome)
Pathway description
Negative regulation of MET activity
Regulation of IFNG signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000033974 HGF / hepatocyte growth factor / P14210* / Q08048* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*  / reaction
 ENSGALG00000007651 STAT1 / signal transducer and activator of transcription 1 / P42224*  / reaction
 ENSGALG00000036883 MET / hepatocyte growth factor receptor precursor / P08581* / MET proto-oncogene, receptor tyrosine kinase*  / reaction






 

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