ENSGALG00000021656


Gallus gallus

Features
Gene ID: ENSGALG00000021656
  
Biological name :PTPN22
  
Synonyms : protein tyrosine phosphatase, non-receptor type 22 / PTPN22
  
Possible biological names infered from orthology : P29352 / Q9Y2R2 / Tyrosine-protein phosphatase non-receptor type 22
  
Species: Gallus gallus
  
Chr. number: 26
Strand: -1
Band:
Gene start: 3747288
Gene end: 3759758
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSGALP00000039315
NCBI entrez gene - 772032     See in Manteia.
RefSeq - XM_001235233
swissprot - E1BXF3
Ensembl - ENSGALG00000021656
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpn22ENSDARG00000104197Danio rerio
 PTPN22ENSG00000134242Homo sapiens
 P29352ENSMUSG00000027843Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTPRJ / receptor-type tyrosine-protein phosphatase eta precursor / Q12913* / protein tyrosine phosphatase, receptor type J*ENSGALG0000000638214
PTPRB / protein tyrosine phosphatase, receptor type B / B2RU80* / P23467*ENSGALG0000001004914
PTPN9 / tyrosine-protein phosphatase non-receptor type 9 / O35239* / P43378* / protein tyrosine phosphatase, non-receptor type 9*ENSGALG0000000166413
PTPRO / receptor-type tyrosine-protein phosphatase O / E9Q612* / Q16827* / protein tyrosine phosphatase, receptor type O*ENSGALG0000001308513
PTPRQ / protein tyrosine phosphatase, receptor type Q / P0C5E4* / Phosphatidylinositol phosphatase PTPRQ *ENSGALG0000001093513
PTPN2 / protein tyrosine phosphatase, non-receptor type 2 / P17706* / Q06180* / Tyrosine-protein phosphatase non-receptor type 2 *ENSGALG0000001386713
PTPN1 / tyrosine-protein phosphatase non-receptor type 1 / P18031* / P35821* / protein tyrosine phosphatase, non-receptor type 1*ENSGALG0000000801012
ENSGALG000000213558
P35831* / PTPN12* / Q05209* / protein tyrosine phosphatase, non-receptor type 12*ENSGALG000000425698
ENSGALG000000005842


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002230 positive regulation of defense response to virus by host IEA
 biological_processGO:0002685 regulation of leukocyte migration IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0030217 T cell differentiation IEA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IEA
 biological_processGO:0034141 positive regulation of toll-like receptor 3 signaling pathway IEA
 biological_processGO:0034145 positive regulation of toll-like receptor 4 signaling pathway IEA
 biological_processGO:0034157 positive regulation of toll-like receptor 7 signaling pathway IEA
 biological_processGO:0034165 positive regulation of toll-like receptor 9 signaling pathway IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0035549 positive regulation of interferon-beta secretion IEA
 biological_processGO:0035644 phosphoanandamide dephosphorylation IEA
 biological_processGO:0042993 obsolete positive regulation of transcription factor import into nucleus IEA
 biological_processGO:0050852 T cell receptor signaling pathway IEA
 biological_processGO:0050868 negative regulation of T cell activation IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070433 negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IEA
 biological_processGO:0071225 cellular response to muramyl dipeptide IEA
 biological_processGO:0071663 positive regulation of granzyme B production IEA
 biological_processGO:1900165 negative regulation of interleukin-6 secretion IEA
 biological_processGO:1901222 regulation of NIK/NF-kappaB signaling IEA
 biological_processGO:1902523 positive regulation of protein K63-linked ubiquitination IEA
 biological_processGO:1902741 positive regulation of interferon-alpha secretion IEA
 biological_processGO:1903753 negative regulation of p38MAPK cascade IEA
 biological_processGO:2000483 negative regulation of interleukin-8 secretion IEA
 biological_processGO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0019900 kinase binding IEA


Pathways (from Reactome)
Pathway description
Phosphorylation of CD3 and TCR zeta chains


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000031270 CSK / tyrosine-protein kinase CSK / P41240* / P41241* / C-terminal Src kinase*  / complex






 

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