ENSGALG00000002160


Gallus gallus

Features
Gene ID: ENSGALG00000002160
  
Biological name :B2M
  
Synonyms : B2M / Beta-2-microglobulin / P21611
  
Possible biological names infered from orthology : P01887 / P61769
  
Species: Gallus gallus
  
Chr. number: 10
Strand: 1
Band:
Gene start: 1254940
Gene end: 1257208
  
Corresponding Affymetrix probe sets: Gga.1328.1.S2_at (Chicken Array)   Gga.1328.2.A1_at (Chicken Array)   GgaAffx.21826.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000039454
NCBI entrez gene - 414830     See in Manteia.
RefSeq - XM_015279077
swissprot - P21611
Ensembl - ENSGALG00000002160
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 b2mENSDARG00000053136Danio rerio
 b2mlENSDARG00000015887Danio rerio
 zmp:0000001138ENSDARG00000071168Danio rerio
 B2MENSG00000166710Homo sapiens
 B2mENSMUSG00000060802Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003006  Immunoglobulin/major histocompatibility complex, conserved site
 IPR003597  Immunoglobulin C1-set
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR015707  Beta-2-Microglobulin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001916 positive regulation of T cell mediated cytotoxicity IEA
 biological_processGO:0002237 response to molecule of bacterial origin IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002474 antigen processing and presentation of peptide antigen via MHC class I IEA
 biological_processGO:0002481 antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent IEA
 biological_processGO:0002726 positive regulation of T cell cytokine production IEA
 biological_processGO:0006826 iron ion transport IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0033077 T cell differentiation in thymus IEA
 biological_processGO:0033216 ferric iron import IEA
 biological_processGO:0042026 protein refolding IEA
 biological_processGO:0045646 regulation of erythrocyte differentiation IEA
 biological_processGO:0048260 positive regulation of receptor-mediated endocytosis IEA
 biological_processGO:0055072 iron ion homeostasis IEA
 biological_processGO:0071281 cellular response to iron ion IEA
 biological_processGO:0071283 cellular response to iron(III) ion IEA
 biological_processGO:1900121 negative regulation of receptor binding IEA
 biological_processGO:1900122 positive regulation of receptor binding IEA
 biological_processGO:1900390 regulation of iron ion import IEA
 biological_processGO:1904434 positive regulation of ferrous iron binding IEA
 biological_processGO:1904437 positive regulation of transferrin receptor binding IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0042612 MHC class I protein complex IEA
 cellular_componentGO:1990712 HFE-transferrin receptor complex IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Antigen Presentation: Folding, assembly and peptide loading of class I MHC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008419 SEC13 / P55735* / Q9D1M0* / SEC13 homolog, nuclear pore and COPII coat complex component*  / complex / reaction
 ENSGALG00000006417 SEC24A / Gallus gallus SEC24 homolog A, COPII coat complex component (SEC24A), mRNA. / O95486* / Q3U2P1* / Protein transport protein Sec24A * / SEC24 homolog A, COPII coat complex component*  / complex
 ENSGALG00000010150 SEC23A / Sec23 homolog A, coat complex II component / Q01405* / Q15436* / Protein transport protein Sec23A *  / complex
 ENSGALG00000011998 SEC24D / SEC24 homolog D, COPII coat complex component / O94855* / Sec24 related gene family, member D (S. cerevisiae)*  / complex
 ENSGALG00000008348 PDIA3 / Q8JG64 / Protein disulfide-isomerase A3 / P30101* / P27773* / protein disulfide isomerase family A member 3*  / complex
 ENSGALG00000040484 SEC31A / protein transport protein Sec31A / O94979* / Q3UPL0* / SEC31 homolog A, COPII coat complex component*  / reaction / complex
 ENSGALG00000038753 SAR1B / GTP-binding protein SAR1b / Q9CQC9* / Q9Y6B6* / secretion associated Ras related GTPase 1B*  / complex






 

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