ENSMUSG00000020986


Mus musculus

Features
Gene ID: ENSMUSG00000020986
  
Biological name :Sec23a
  
Synonyms : Protein transport protein Sec23A / Q01405 / Sec23a
  
Possible biological names infered from orthology : Q15436 / Sec23 homolog A, coat complex II component
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: C1
Gene start: 58958383
Gene end: 59012017
  
Corresponding Affymetrix probe sets: 10400515 (MoGene1.0st)   1423347_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126011
Ensembl peptide - ENSMUSP00000021375
NCBI entrez gene - 20334     See in Manteia.
MGI - MGI:1349635
RefSeq - NM_009147
RefSeq - XM_006515628
RefSeq Peptide - NP_033173
swissprot - E9Q1S3
swissprot - Q01405
Ensembl - ENSMUSG00000020986
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q7SZE5ENSDARG00000104230Danio rerio
 SEC23AENSGALG00000010150Gallus gallus
 Q15436ENSG00000100934Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9D662 / Sec23b / Mus musculus SEC23 homolog B, COPII coat complex component (Sec23b), transcript variant 7, mRNA. / Q15437* / Sec23 homolog B, coat complex II component*ENSMUSG0000002742985


Protein motifs (from Interpro)
Interpro ID Name
 IPR006895  Zinc finger, Sec23/Sec24-type
 IPR006896  Sec23/Sec24, trunk domain
 IPR006900  Sec23/Sec24, helical domain
 IPR007123  Gelsolin-like domain
 IPR012990  Sec23/Sec24 beta-sandwich
 IPR029006  ADF-H/Gelsolin-like domain superfamily
 IPR036174  Zinc finger, Sec23/Sec24-type superfamily
 IPR036175  Sec23/Sec24 helical domain superfamily
 IPR036180  Gelsolin-like domain superfamily
 IPR036465  von Willebrand factor A-like domain superfamily
 IPR037364  Protein transport protein Sec23
 IPR037550  Sec23, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0090110 cargo loading into COPII-coated vesicle IEA
 biological_processGO:0090114 COPII-coated vesicle budding IEA
 cellular_componentGO:0000139 Golgi membrane IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0012507 ER to Golgi transport vesicle membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019898 extrinsic component of membrane IEA
 cellular_componentGO:0030127 COPII vesicle coat IEA
 cellular_componentGO:0030134 COPII-coated ER to Golgi transport vesicle IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0070971 endoplasmic reticulum exit site IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport
MHC class II antigen presentation
Cargo concentration in the ER
Antigen Presentation: Folding, assembly and peptide loading of class I MHC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Col5a2tm1.2Dgr/Col5a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Col5a2tm1.2Dgr/Col5a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Col5a2tm1.2Dgr/Col5a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
Show

Allelic Composition: Col5a2tm1.2Dgr/Col5a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Col5a2tm1.2Dgr/Col5a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Col5a2tm1.2Dgr/Col5a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col5a2tm1.2Dgr/Col5a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Col5a2tm1.2Dgr/Col5a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0004264 abnormal extraembryonic tissue physiology "functional anomaly of the membranes involved with embryonic protection and nutrition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col5a2tm1.2Dgr/Col5a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0005029 abnormal amnion "malformed innermost layer of the extraembryonic membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Col5a2tm1.2Dgr/Col5a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rnf10tm1a(KOMP)Wtsi/Rnf10tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1a(KOMP)Wtsi/Wtsi

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Col5a2tm1.2Dgr/Col5a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

Allelic Composition: Sec23aGt(RRE297)Byg/Sec23aGt(RRE297)Byg,Sec23bGt(AD0407)Wtsi/Sec23b+
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi Sec23aGt(RRE297)Byg

 MP:0012681 collapsed brain ventricles "the luminal space of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord are severely reduced in volume or area, possibly due to reduced or absent cerebrospinal fluid production; collapsed ventricles can be a sign of increased intracranial pressure and accumulation of water in the brain parenchyma" [MGI:anna]
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Allelic Composition: Col5a2tm1.2Dgr/Col5a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0012706 decreased embryonic neuroepithelial cell proliferation "decrease in the expansion rate of the cells of the embryonic neuroepithelium by cell division" [CL:0000710, MGI:anna]
Show

Allelic Composition: Col5a2tm1.2Dgr/Col5a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0013227 small brain ventricles "decreased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:anna]
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Allelic Composition: Col5a2tm1.2Dgr/Col5a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Sec23aGt(RRE297)Byg/Sec23aGt(RRE297)Byg,Sec23bGt(AD0407)Wtsi/Sec23b+
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi Sec23aGt(RRE297)Byg

Allelic Composition: Sec23aGt(RRE297)Byg/Sec23a+,Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi Sec23aGt(RRE297)Byg

 MP:0020252 abnormal collagen level "abnormal level of the main structural protein of the various connective tissues in animals" [GOC:NV, PMID:11704682]
Show

Allelic Composition: Col5a2tm1.2Dgr/Col5a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0020354 increased endoplasmic reticulum stress "increase in in the accumulation of misfolded or unfolded proteins in the endoplasmic reticulum lumen; this accumulation may be stimulated by genetic or enviromental factors" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Col5a2tm1.2Dgr/Col5a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0020413 increased amnion apoptosis "increase in the number of cells of the amnion undergoing programmed cell death" [mgi:anna, PMID:26494538]
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Allelic Composition: Col5a2tm1.2Dgr/Col5a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001052 Sec24b / Sec24 related gene family, member B (S. cerevisiae) / O95487* / SEC24 homolog B, COPII coat complex component*  / complex / reaction
 ENSMUSG00000020386 Sar1b / Q9CQC9 / secretion associated Ras related GTPase 1B / Q9Y6B6*  / reaction / complex
 ENSMUSG00000025162 Csnk1d / Q9DC28 / casein kinase 1, delta / P48730*  / reaction
 ENSMUSG00000030298 Sec13 / Q9D1M0 / SEC13 homolog, nuclear pore and COPII coat complex component / P55735*  / reaction / complex
 ENSMUSG00000026589 Q91XT4 / Sec16b / Protein transport protein Sec16B / Q96JE7* / SEC16 homolog B, endoplasmic reticulum export factor*  / reaction / complex
 ENSMUSG00000060586 H2-Eb1 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / reaction / complex
 ENSMUSG00000036594 H2-Aa / P14434 / H-2 class II histocompatibility antigen, A-B alpha chain / P01909* / P01906* / HLA-DQA2* / HLA-DQA1* / major histocompatibility complex, class II, DQ alpha 2* / major hist...  / reaction / complex
 ENSMUSG00000073421 H2-Ab1 / P14483 / histocompatibility 2, class II antigen A, beta 1 / P05538* / HLA-DQB1* / HLA-DQB2* / major histocompatibility complex, class II, DQ beta 1* / major histocompatibility comp...  / reaction / complex
 ENSMUSG00000002546 Golga2 / Q921M4 / golgi autoantigen, golgin subfamily a, 2 / A7E2F4* / A8MQT2* / D6RF30* / F8WBI6* / A6NCC3* / A6NDK9* / A6NDN3* / A6NMD2* / H3BSY2* / I6L899* / P0CG33* / P0CJ92* / Q08379* ...  / complex / reaction
 ENSMUSG00000029407 Uso1 / Q9Z1Z0 / USO1 vesicle docking factor / O60763* / USO1 vesicle transport factor*  / reaction / complex
 ENSMUSG00000020946 Gosr2 / O35166 / golgi SNAP receptor complex member 2 / O14653* / AC005670.2*  / reaction / complex
 ENSMUSG00000039234 Sec24d / Sec24 related gene family, member D (S. cerevisiae) / O94855* / SEC24 homolog D, COPII coat complex component*  / reaction / complex
 ENSMUSG00000024610 Cd74 / P04441 / CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) / P04233* / CD74 molecule*  / reaction / complex
 ENSMUSG00000035325 Q3UPL0 / Sec31a / Protein transport protein Sec31A / O94979* / SEC31 homolog A, COPII coat complex component*  / complex / reaction
 ENSMUSG00000010110 Stx5a / Q8K1E0 / Syntaxin-5 / STX5* / Q13190*  / complex / reaction
 ENSMUSG00000036391 Q3U2P1 / Sec24a / Protein transport protein Sec24A / O95486* / SEC24 homolog A, COPII coat complex component*  / complex / reaction
 ENSMUSG00000027879 O08547 / Sec22b / Vesicle-trafficking protein SEC22b / O75396* / SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)*  / complex / reaction
 ENSMUSG00000020149 Rab1 / P62821 / Ras-related protein Rab-1A / RAB1A* / P62820* / RAB1A, member RAS oncogene family*  / complex / reaction
 ENSMUSG00000026924 Sec16a / SEC16 homolog A, endoplasmic reticulum export factor / O15027*  / reaction / complex
 ENSMUSG00000067341 H2-Eb2 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / reaction / complex
 ENSMUSG00000032513 Q91X51 / Gorasp1 / golgi reassembly stacking protein 1 / Q9BQQ3*  / reaction / complex
 ENSMUSG00000045302 Preb / Q9WUQ2 / prolactin regulatory element binding / Q9HCU5*  / reaction / complex
 ENSMUSG00000055319 Sec23ip / Sec23 interacting protein / Q9Y6Y8*  / complex / reaction
 ENSMUSG00000060802 B2m / P01887 / Beta-2-microglobulin / P61769*  / reaction / complex
 ENSMUSG00000021000 Mia2 / Q91ZV0 / Mus musculus melanoma inhibitory activity 2 (Mia2), transcript variant 1, mRNA. / CTAGE5* / CTAGE6* / CTAGE8* / CTAGE9* / A4D2H0* / A4FU28* / CTAGE1* / CTAGE4* / O15320* / P...  / reaction / complex






 

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