ENSMUSG00000027429


Mus musculus

Features
Gene ID: ENSMUSG00000027429
  
Biological name :Sec23b
  
Synonyms : Mus musculus SEC23 homolog B, COPII coat complex component (Sec23b), transcript variant 7, mRNA. / Q9D662 / Sec23b
  
Possible biological names infered from orthology : Q15437 / Sec23 homolog B, coat complex II component
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: G1
Gene start: 144556229
Gene end: 144590749
  
Corresponding Affymetrix probe sets: 10476702 (MoGene1.0st)   1416059_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123690
Ensembl peptide - ENSMUSP00000028916
Ensembl peptide - ENSMUSP00000120972
Ensembl peptide - ENSMUSP00000122819
Ensembl peptide - ENSMUSP00000122884
NCBI entrez gene - 27054     See in Manteia.
MGI - MGI:1350925
RefSeq - XM_017318899
RefSeq - NM_001252543
RefSeq - NM_001252544
RefSeq - NM_001252545
RefSeq - NM_001281816
RefSeq - NM_001355380
RefSeq - NM_019787
RefSeq Peptide - NP_062761
RefSeq Peptide - NP_001239473
RefSeq Peptide - NP_001239474
RefSeq Peptide - NP_001268745
RefSeq Peptide - NP_001342308
RefSeq Peptide - NP_001342309
RefSeq Peptide - NP_001239472
swissprot - Q9D662
swissprot - A2AN97
swissprot - A2ANA0
swissprot - A2AN99
swissprot - A2AN98
Ensembl - ENSMUSG00000027429
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sec23bENSDARG00000019360Danio rerio
 SEC23BENSGALG00000008793Gallus gallus
 Q15437ENSG00000101310Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q01405 / Sec23a / Protein transport protein Sec23A / Q15436* / Sec23 homolog A, coat complex II component*ENSMUSG0000002098684


Protein motifs (from Interpro)
Interpro ID Name
 IPR006895  Zinc finger, Sec23/Sec24-type
 IPR006896  Sec23/Sec24, trunk domain
 IPR006900  Sec23/Sec24, helical domain
 IPR007123  Gelsolin-like domain
 IPR012990  Sec23/Sec24 beta-sandwich
 IPR029006  ADF-H/Gelsolin-like domain superfamily
 IPR036174  Zinc finger, Sec23/Sec24-type superfamily
 IPR036175  Sec23/Sec24 helical domain superfamily
 IPR036180  Gelsolin-like domain superfamily
 IPR036465  von Willebrand factor A-like domain superfamily
 IPR037364  Protein transport protein Sec23
 IPR037550  Sec23, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0090114 COPII-coated vesicle budding IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0012507 ER to Golgi transport vesicle membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030127 COPII vesicle coat IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000473 abnormal stomach glandular epithelium morphology "malformation of the gland-containing epithelial layer of the stomach" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:54637]
Show

Allelic Composition: Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi

 MP:0000613 abnormal salivary gland morphology "malformed saliva-secreting glands of the oral cavity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
Show

Allelic Composition: Dnah5b2b1537Clo/Dnah5b2b1537Clo
Genetic Background: C57BL/6J-Dnah5b2b1537Clo

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
Show

Allelic Composition: Dnah5b2b1537Clo/Dnah5b2b1537Clo
Genetic Background: C57BL/6J-Dnah5b2b1537Clo

Allelic Composition: Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
Show

Allelic Composition: Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi

 MP:0003793 abnormal submandibular gland morphology "any structural malformation of either of the large major salivary glands situated beneath the mandible" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi

 MP:0004035 abnormal sublingual gland morphology "malformation of the small mucin-producing salivary glands in the floor of the mouth beneath the tongue, anterior to the submandibular gland" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi

 MP:0004247 small pancreas "decrease of the size of the pancreas compared to controls" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi

 MP:0004843 abnormal Paneth cell morphology "any structural anomaly of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi

 MP:0009145 abnormal pancreatic acinus morphology "any structural anomaly of the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi

 MP:0009146 abnormal pancreatic acinar cell morphology "any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi

 MP:0009149 decreased pancreatic acinar cell number "reduced number of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi

 MP:0009154 pancreatic acinar hypoplasia "underdevelopment or reduced size of the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced, usually due to a decreased cell number" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi

 MP:0009162 absent pancreatic acinar cell zymogen granule "absence of a membrane-bounded, cytoplasmic secretory granule found in pancreatic acinar cells and contains inactive digestive enzyme precursors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi

 MP:0009165 abnormal endocrine pancreas morphology "any structural anomaly of the smaller portion of the pancreas that secretes a number of hormones into the blood stream that are produced by the cells in the islets of Langerhans" [MESH:A03.734]
Show

Allelic Composition: Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi

 MP:0009168 decreased pancreatic islet number "reduction in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi

 MP:0009177 decreased pancreatic alpha cell number "reduction in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
Show

Allelic Composition: Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Dnah5b2b1537Clo/Dnah5b2b1537Clo
Genetic Background: C57BL/6J-Dnah5b2b1537Clo

Allelic Composition: Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi

 MP:0010148 abnormal exocrine pancreas physiology "any functional anomaly of the acinar gland portion of the pancreas that secretes digestive enzymes" [MESH:A03.734.540, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Dnah5b2b1537Clo/Dnah5b2b1537Clo
Genetic Background: C57BL/6J-Dnah5b2b1537Clo

Allelic Composition: Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi

Allelic Composition: Sec23btm1a(EUCOMM)Wtsi/Sec23btm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Sec23btm1b(EUCOMM)Wtsi/Sec23btm1b(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Sec23aGt(RRE297)Byg/Sec23aGt(RRE297)Byg,Sec23bGt(AD0407)Wtsi/Sec23b+
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi Sec23aGt(RRE297)Byg

 MP:0011932 abnormal endocrine pancreas development 
Show

Allelic Composition: Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Sec23aGt(RRE297)Byg/Sec23aGt(RRE297)Byg,Sec23bGt(AD0407)Wtsi/Sec23b+
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi Sec23aGt(RRE297)Byg

Allelic Composition: Sec23aGt(RRE297)Byg/Sec23a+,Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi Sec23aGt(RRE297)Byg

 MP:0013568 gastric gland degeneration "a retrogressive impairment of function or destruction of any of the branched tubular glands found in the mucosa of the fundus and body of the stomach which contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin" [MGI:Anna]
Show

Allelic Composition: Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi

Allelic Composition: Sec23btm1a(EUCOMM)Wtsi/Sec23btm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Sec23btm1b(EUCOMM)Wtsi/Sec23btm1b(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N

 MP:0013581 nasal gland degeneration "a retrogressive impairment of function or destruction of any of the seromucous glands found in the respiratory region of the nasal mucous membrane" [http://en.wikipedia.org/wiki/Nasal_glands, MGI:Anna]
Show

Allelic Composition: Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi

Allelic Composition: Sec23btm1a(EUCOMM)Wtsi/Sec23btm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Sec23btm1b(EUCOMM)Wtsi/Sec23btm1b(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N

 MP:0013583 salivary gland degeneration "a retrogressive impairment of function or destruction of any of the saliva-secreting glands of the oral cavity" [MGI:Anna]
Show

Allelic Composition: Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi

Allelic Composition: Sec23btm1a(EUCOMM)Wtsi/Sec23btm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Sec23btm1b(EUCOMM)Wtsi/Sec23btm1b(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N

 MP:0013584 pancreas degeneration "a retrogressive impairment of function or destruction of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [MGI:Anna]
Show

Allelic Composition: Sec23bGt(AD0407)Wtsi/Sec23bGt(AD0407)Wtsi
Genetic Background: B6J.129P2-Sec23bGt(AD0407)Wtsi

Allelic Composition: Sec23btm1a(EUCOMM)Wtsi/Sec23btm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Sec23btm1b(EUCOMM)Wtsi/Sec23btm1b(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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