ENSMUSG00000023845


Mus musculus

Features
Gene ID: ENSMUSG00000023845
  
Biological name :Lnpep
  
Synonyms : Leucyl-cystinyl aminopeptidase / Lnpep / Q8C129
  
Possible biological names infered from orthology : leucyl and cystinyl aminopeptidase / Q9UIQ6
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.2
Gene start: 17527723
Gene end: 17624489
  
Corresponding Affymetrix probe sets: 10448094 (MoGene1.0st)   1433747_at (Mouse Genome 430 2.0 Array)   1439326_at (Mouse Genome 430 2.0 Array)   1443907_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036998
NCBI entrez gene - 240028     See in Manteia.
MGI - MGI:2387123
RefSeq - NM_172827
RefSeq Peptide - NP_766415
swissprot - Q8C129
Ensembl - ENSMUSG00000023845
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lnpepENSDARG00000100394Danio rerio
 LNPEPENSGALG00000015301Gallus gallus
 LNPEPENSG00000113441Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Erap1 / Q9EQH2 / Endoplasmic reticulum aminopeptidase 1 / Q9NZ08*ENSMUSG0000002158341
Trhde / Q8K093 / Thyrotropin-releasing hormone-degrading ectoenzyme / Q9UKU6* / thyrotropin releasing hormone degrading enzyme*ENSMUSG0000005066328
Anpep / P97449 / Aminopeptidase N / P15144* / alanyl aminopeptidase, membrane*ENSMUSG0000003906228
Enpep / P16406 / glutamyl aminopeptidase / Q07075*ENSMUSG0000002802428
Npepps / Q11011 / Puromycin-sensitive aminopeptidase / P55786* / aminopeptidase puromycin sensitive*ENSMUSG0000000144127
Lvrn / laeverin / Q6Q4G3*ENSMUSG0000002448125


Protein motifs (from Interpro)
Interpro ID Name
 IPR001930  Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
 IPR014782  Peptidase M1, membrane alanine aminopeptidase, N-terminal
 IPR024571  ERAP1-like C-terminal domain
 IPR034016  Aminopeptidase N-type
 IPR034017  Cystinyl aminopeptidase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0008217 regulation of blood pressure IBA
 biological_processGO:0030163 protein catabolic process IMP
 biological_processGO:0043171 peptide catabolic process IBA
 biological_processGO:0060395 SMAD protein signal transduction IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IMP
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0004177 aminopeptidase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042277 peptide binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070006 metalloaminopeptidase activity IBA


Pathways (from Reactome)
Pathway description
Endosomal/Vacuolar pathway
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Col10a1tm1.1Rpbh/Col10a1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myo10tm1d(KOMP)Wtsi/Myo10tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NJ

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Myo10tm1d(KOMP)Wtsi/Myo10tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NJ

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo10tm1d(KOMP)Wtsi/Myo10tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NJ

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myo10tm1d(KOMP)Wtsi/Myo10tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NJ

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myo10tm1d(KOMP)Wtsi/Myo10tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NJ

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myo10tm1d(KOMP)Wtsi/Myo10tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NJ

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Myo10tm1d(KOMP)Wtsi/Myo10tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NJ

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Myo10tm1d(KOMP)Wtsi/Myo10tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NJ

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col10a1tm1.1Rpbh/Col10a1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009122 decreased white fat cell lipid droplet size "reduction in the size of the single large lipid droplet or vacuole of white fat cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo10tm1d(KOMP)Wtsi/Myo10tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NJ

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo10tm1d(KOMP)Wtsi/Myo10tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NJ

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo10tm1d(KOMP)Wtsi/Myo10tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NJ

 MP:0011016 increased core body temperature "increased degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo10tm1d(KOMP)Wtsi/Myo10tm1d(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000060802 B2m / P01887 / Beta-2-microglobulin / P61769*  / complex






 

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