ENSMUSG00000039062


Mus musculus

Features
Gene ID: ENSMUSG00000039062
  
Biological name :Anpep
  
Synonyms : Aminopeptidase N / Anpep / P97449
  
Possible biological names infered from orthology : alanyl aminopeptidase, membrane / P15144
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: D2
Gene start: 79821803
Gene end: 79861059
  
Corresponding Affymetrix probe sets: 10564818 (MoGene1.0st)   1421424_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103015
Ensembl peptide - ENSMUSP00000146085
Ensembl peptide - ENSMUSP00000145682
Ensembl peptide - ENSMUSP00000035943
NCBI entrez gene - 16790     See in Manteia.
MGI - MGI:5000466
RefSeq - NM_008486
RefSeq - XM_006540678
RefSeq Peptide - NP_032512
swissprot - A0A0U1RPR2
swissprot - P97449
swissprot - A0A0U1RNS3
Ensembl - ENSMUSG00000039062
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ANPEPENSDARG00000089706Danio rerio
 anpepbENSDARG00000103878Danio rerio
 si:ch211-106j24.1ENSDARG00000036809Danio rerio
 si:ch211-147g22.5ENSDARG00000097285Danio rerio
 ANPEPENSGALG00000027501Gallus gallus
 ANPEPENSG00000166825Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lvrn / laeverin / Q6Q4G3*ENSMUSG0000002448134
Enpep / P16406 / glutamyl aminopeptidase / Q07075*ENSMUSG0000002802431
Trhde / Q8K093 / Thyrotropin-releasing hormone-degrading ectoenzyme / Q9UKU6* / thyrotropin releasing hormone degrading enzyme*ENSMUSG0000005066331
Lnpep / Q8C129 / Leucyl-cystinyl aminopeptidase / Q9UIQ6* / leucyl and cystinyl aminopeptidase*ENSMUSG0000002384530
Erap1 / Q9EQH2 / Endoplasmic reticulum aminopeptidase 1 / Q9NZ08*ENSMUSG0000002158330
Npepps / Q11011 / Puromycin-sensitive aminopeptidase / P55786* / aminopeptidase puromycin sensitive*ENSMUSG0000000144128


Protein motifs (from Interpro)
Interpro ID Name
 IPR001930  Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
 IPR014782  Peptidase M1, membrane alanine aminopeptidase, N-terminal
 IPR024571  ERAP1-like C-terminal domain
 IPR034016  Aminopeptidase N-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006508 proteolysis IBA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008217 regulation of blood pressure IBA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0043171 peptide catabolic process IBA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome ISO
 molecular_functionGO:0004177 aminopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042277 peptide binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070006 metalloaminopeptidase activity IBA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scn1btm1.1Bion/Scn1b+
Genetic Background: Not Specified

 MP:0003711 abnormal pathological neovascularization "the proliferation of blood vessels in abnormal tissues or in abnormal positions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scn1btm1.1Bion/Scn1b+
Genetic Background: Not Specified

 MP:0008852 retinal neovascularization "formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina" [MESH:C11.768.725]
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Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Tg(Pax2-cre)1Akg/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Anpeptm1Sid/Anpep+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0012075 impaired mammary gland growth during pregnancy "defect in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation in preparation for lactation" [MGI:llw2]
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Allelic Composition: Politm1.1Lgh/Politm1.1Lgh,Tg(gptdelta)1Nmi/0
Genetic Background: involves: C57BL/6J

Allelic Composition: Anpeptm1Afk/Anpeptm1Afk
Genetic Background: B6.129-Anpeptm1Afk

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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