ENSMUSG00000001441


Mus musculus

Features
Gene ID: ENSMUSG00000001441
  
Biological name :Npepps
  
Synonyms : Npepps / Puromycin-sensitive aminopeptidase / Q11011
  
Possible biological names infered from orthology : aminopeptidase puromycin sensitive / P55786
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 97205842
Gene end: 97280638
  
Corresponding Affymetrix probe sets: 10390381 (MoGene1.0st)   1417385_at (Mouse Genome 430 2.0 Array)   1417386_at (Mouse Genome 430 2.0 Array)   1445463_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000129623
Ensembl peptide - ENSMUSP00000129361
Ensembl peptide - ENSMUSP00000130445
Ensembl peptide - ENSMUSP00000001480
Ensembl peptide - ENSMUSP00000119644
Ensembl peptide - ENSMUSP00000127127
Ensembl peptide - ENSMUSP00000127631
Ensembl peptide - ENSMUSP00000127801
Ensembl peptide - ENSMUSP00000128169
NCBI entrez gene - 19155     See in Manteia.
MGI - MGI:1101358
RefSeq - XM_017314341
RefSeq - NM_008942
RefSeq - XM_006532514
RefSeq - XM_011248802
RefSeq Peptide - NP_032968
swissprot - F6Z7Y0
swissprot - F7ANF4
swissprot - E9Q6F4
swissprot - E9Q039
swissprot - Q11011
swissprot - F2Z3V5
swissprot - F6QYF8
swissprot - F6V7K3
swissprot - F6RAU6
Ensembl - ENSMUSG00000001441
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 npeppsENSDARG00000044943Danio rerio
 NPEPPSENSGALG00000031332Gallus gallus
 NPEPPSENSG00000141279Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Erap1 / Q9EQH2 / Endoplasmic reticulum aminopeptidase 1 / Q9NZ08*ENSMUSG0000002158332
Lnpep / Q8C129 / Leucyl-cystinyl aminopeptidase / Q9UIQ6* / leucyl and cystinyl aminopeptidase*ENSMUSG0000002384530
Enpep / P16406 / glutamyl aminopeptidase / Q07075*ENSMUSG0000002802430
Anpep / P97449 / Aminopeptidase N / P15144* / alanyl aminopeptidase, membrane*ENSMUSG0000003906229
Trhde / Q8K093 / Thyrotropin-releasing hormone-degrading ectoenzyme / Q9UKU6* / thyrotropin releasing hormone degrading enzyme*ENSMUSG0000005066329
Lvrn / laeverin / Q6Q4G3*ENSMUSG0000002448125


Protein motifs (from Interpro)
Interpro ID Name
 IPR001930  Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
 IPR014782  Peptidase M1, membrane alanine aminopeptidase, N-terminal
 IPR024571  ERAP1-like C-terminal domain
 IPR034016  Aminopeptidase N-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0043171 peptide catabolic process IBA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004177 aminopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042277 peptide binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070006 metalloaminopeptidase activity IBA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Tcrg-C1tm2.1Dhr/Tcrg-C1tm2.1Dhr
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001380 male reduced copulation without impotence "males do not initiate sexual behavior as scored by the presence of copulation plugs (not due to infertility)" [J:57125]
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Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Tcrg-C1tm2.1Dhr/Tcrg-C1tm2.1Dhr
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Tcrg-C1tm2.1Dhr/Tcrg-C1tm2.1Dhr
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tcrg-C1tm2.1Dhr/Tcrg-C1tm2.1Dhr
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002773 decreased circulating luteinizing hormone level "lower than normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35132, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002790 decreased circulating follicle stimulating hormone level "less than expected blood concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005121 decreased circulating prolactin level "less than expected blood concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxb4tm1Nrm/Hoxb4tm1Nrm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Tcrg-C1tm2.1Dhr/Tcrg-C1tm2.1Dhr
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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