ENSG00000141279


Homo sapiens

Features
Gene ID: ENSG00000141279
  
Biological name :NPEPPS
  
Synonyms : aminopeptidase puromycin sensitive / NPEPPS / P55786
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q21.32
Gene start: 47522942
Gene end: 47623276
  
Corresponding Affymetrix probe sets: 201454_s_at (Human Genome U133 Plus 2.0 Array)   201455_s_at (Human Genome U133 Plus 2.0 Array)   214101_s_at (Human Genome U133 Plus 2.0 Array)   214107_x_at (Human Genome U133 Plus 2.0 Array)   215090_x_at (Human Genome U133 Plus 2.0 Array)   242612_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000432127
Ensembl peptide - ENSP00000433287
Ensembl peptide - ENSP00000437019
Ensembl peptide - ENSP00000436733
Ensembl peptide - ENSP00000435966
Ensembl peptide - ENSP00000435639
Ensembl peptide - ENSP00000434585
Ensembl peptide - ENSP00000434554
Ensembl peptide - ENSP00000433735
Ensembl peptide - ENSP00000433649
Ensembl peptide - ENSP00000433549
Ensembl peptide - ENSP00000320324
NCBI entrez gene - 9520     See in Manteia.
OMIM - 606793
RefSeq - NM_001330257
RefSeq - XM_017025372
RefSeq - XM_017025373
RefSeq - NM_006310
RefSeq - XM_011525496
RefSeq Peptide - NP_001317186
RefSeq Peptide - NP_006301
swissprot - E9PJ74
swissprot - E9PI82
swissprot - E9PRQ5
swissprot - H0YDG0
swissprot - P55786
swissprot - H0YCQ5
swissprot - E9PPZ2
swissprot - E9PPD4
swissprot - E9PP11
swissprot - E9PLK3
swissprot - E9PJY4
swissprot - E9PJF9
Ensembl - ENSG00000141279
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 npeppsENSDARG00000044943Danio rerio
 NPEPPSENSGALG00000031332Gallus gallus
 NpeppsENSMUSG00000001441Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ENPEP / Q07075 / glutamyl aminopeptidaseENSG0000013879232
ERAP2 / Q6P179 / endoplasmic reticulum aminopeptidase 2ENSG0000016430831
ERAP1 / Q9NZ08 / endoplasmic reticulum aminopeptidase 1ENSG0000016430731
ANPEP / P15144 / alanyl aminopeptidase, membraneENSG0000016682530
TRHDE / Q9UKU6 / thyrotropin releasing hormone degrading enzymeENSG0000007265729
LNPEP / Q9UIQ6 / leucyl and cystinyl aminopeptidaseENSG0000011344129
LVRN / Q6Q4G3 / laeverinENSG0000017290126


Protein motifs (from Interpro)
Interpro ID Name
 IPR001930  Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
 IPR014782  Peptidase M1, membrane alanine aminopeptidase, N-terminal
 IPR024571  ERAP1-like C-terminal domain
 IPR034016  Aminopeptidase N-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0043171 peptide catabolic process IBA
 biological_processGO:0071456 cellular response to hypoxia IDA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004177 aminopeptidase activity EXP
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042277 peptide binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070006 metalloaminopeptidase activity IBA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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