ENSG00000164308


Homo sapiens

Features
Gene ID: ENSG00000164308
  
Biological name :ERAP2
  
Synonyms : endoplasmic reticulum aminopeptidase 2 / ERAP2 / Q6P179
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q15
Gene start: 96875939
Gene end: 96919716
  
Corresponding Affymetrix probe sets: 1554272_at (Human Genome U133 Plus 2.0 Array)   1554273_a_at (Human Genome U133 Plus 2.0 Array)   219759_at (Human Genome U133 Plus 2.0 Array)   227462_at (Human Genome U133 Plus 2.0 Array)   235104_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000425415
Ensembl peptide - ENSP00000425758
Ensembl peptide - ENSP00000427573
Ensembl peptide - ENSP00000426655
Ensembl peptide - ENSP00000369235
Ensembl peptide - ENSP00000400376
Ensembl peptide - ENSP00000421175
Ensembl peptide - ENSP00000421849
NCBI entrez gene - 64167     See in Manteia.
OMIM - 609497
RefSeq - XM_011543544
RefSeq - NM_001130140
RefSeq - NM_022350
RefSeq Peptide - NP_001123612
RefSeq Peptide - NP_071745
swissprot - D6RGW0
swissprot - H0YAL8
swissprot - H0Y9X9
swissprot - D6RF46
swissprot - Q6P179
Ensembl - ENSG00000164308
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 erap2ENSDARG00000098618Danio rerio


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ERAP1 / Q9NZ08 / endoplasmic reticulum aminopeptidase 1ENSG0000016430749
LNPEP / Q9UIQ6 / leucyl and cystinyl aminopeptidaseENSG0000011344142
ENPEP / Q07075 / glutamyl aminopeptidaseENSG0000013879233
TRHDE / Q9UKU6 / thyrotropin releasing hormone degrading enzymeENSG0000007265731
ANPEP / P15144 / alanyl aminopeptidase, membraneENSG0000016682531
NPEPPS / P55786 / aminopeptidase puromycin sensitiveENSG0000014127929
LVRN / Q6Q4G3 / laeverinENSG0000017290128


Protein motifs (from Interpro)
Interpro ID Name
 IPR001930  Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
 IPR014782  Peptidase M1, membrane alanine aminopeptidase, N-terminal
 IPR024571  ERAP1-like C-terminal domain
 IPR033528  ERAP2 aminopeptidase
 IPR034016  Aminopeptidase N-type
 IPR034017  Cystinyl aminopeptidase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0008217 regulation of blood pressure TAS
 biological_processGO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I IEA
 biological_processGO:0043171 peptide catabolic process IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004175 endopeptidase activity EXP
 molecular_functionGO:0004177 aminopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042277 peptide binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070006 metalloaminopeptidase activity IEA


Pathways (from Reactome)
Pathway description
Antigen Presentation: Folding, assembly and peptide loading of class I MHC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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