ENSG00000166825


Homo sapiens

Features
Gene ID: ENSG00000166825
  
Biological name :ANPEP
  
Synonyms : alanyl aminopeptidase, membrane / ANPEP / P15144
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q26.1
Gene start: 89784889
Gene end: 89815401
  
Corresponding Affymetrix probe sets: 202888_s_at (Human Genome U133 Plus 2.0 Array)   234458_at (Human Genome U133 Plus 2.0 Array)   234576_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000300060
Ensembl peptide - ENSP00000453405
Ensembl peptide - ENSP00000453413
Ensembl peptide - ENSP00000453545
Ensembl peptide - ENSP00000452934
NCBI entrez gene - 290     See in Manteia.
OMIM - 151530
RefSeq - XM_011521473
RefSeq - NM_001150
RefSeq - XM_005254892
RefSeq Peptide - NP_001141
swissprot - H0YMC1
swissprot - A0A024RC61
swissprot - H0YM04
swissprot - P15144
swissprot - H0YKT6
swissprot - H0YLZ8
Ensembl - ENSG00000166825
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ANPEPENSDARG00000089706Danio rerio
 anpepbENSDARG00000103878Danio rerio
 si:ch211-106j24.1ENSDARG00000036809Danio rerio
 si:ch211-147g22.5ENSDARG00000097285Danio rerio
 ANPEPENSGALG00000027501Gallus gallus
 AnpepENSMUSG00000039062Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LVRN / Q6Q4G3 / laeverinENSG0000017290135
ENPEP / Q07075 / glutamyl aminopeptidaseENSG0000013879233
TRHDE / Q9UKU6 / thyrotropin releasing hormone degrading enzymeENSG0000007265732
ERAP2 / Q6P179 / endoplasmic reticulum aminopeptidase 2ENSG0000016430831
ERAP1 / Q9NZ08 / endoplasmic reticulum aminopeptidase 1ENSG0000016430730
LNPEP / Q9UIQ6 / leucyl and cystinyl aminopeptidaseENSG0000011344130
NPEPPS / P55786 / aminopeptidase puromycin sensitiveENSG0000014127929


Protein motifs (from Interpro)
Interpro ID Name
 IPR001930  Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
 IPR014782  Peptidase M1, membrane alanine aminopeptidase, N-terminal
 IPR024571  ERAP1-like C-terminal domain
 IPR034016  Aminopeptidase N-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008217 regulation of blood pressure IBA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0043171 peptide catabolic process IBA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0046718 viral entry into host cell IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005765 lysosomal membrane HDA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030667 secretory granule membrane TAS
 cellular_componentGO:0070062 extracellular exosome IDA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0004177 aminopeptidase activity TAS
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042277 peptide binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070006 metalloaminopeptidase activity IBA


Pathways (from Reactome)
Pathway description
Metabolism of Angiotensinogen to Angiotensins
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000135744 AGT / P01019 / angiotensinogen  / reaction
 ENSG00000166825 ANPEP / P15144 / alanyl aminopeptidase, membrane  / complex






 

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