ENSG00000072657


Homo sapiens

Features
Gene ID: ENSG00000072657
  
Biological name :TRHDE
  
Synonyms : Q9UKU6 / thyrotropin releasing hormone degrading enzyme / TRHDE
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q21.1
Gene start: 72087266
Gene end: 72670757
  
Corresponding Affymetrix probe sets: 219937_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000261180
Ensembl peptide - ENSP00000447822
NCBI entrez gene - 29953     See in Manteia.
OMIM - 606950
RefSeq - XM_017019244
RefSeq - NM_013381
RefSeq - XM_011538248
RefSeq - XM_017019243
RefSeq Peptide - NP_037513
swissprot - H0YHU0
swissprot - Q9UKU6
Ensembl - ENSG00000072657
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trhde.1ENSDARG00000111837Danio rerio
 trhde.1ENSDARG00000109358Danio rerio
 TRHDEENSGALG00000010200Gallus gallus
 TrhdeENSMUSG00000050663Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ENPEP / Q07075 / glutamyl aminopeptidaseENSG0000013879230
ANPEP / P15144 / alanyl aminopeptidase, membraneENSG0000016682530
LVRN / Q6Q4G3 / laeverinENSG0000017290129
ERAP2 / Q6P179 / endoplasmic reticulum aminopeptidase 2ENSG0000016430829
LNPEP / Q9UIQ6 / leucyl and cystinyl aminopeptidaseENSG0000011344129
ERAP1 / Q9NZ08 / endoplasmic reticulum aminopeptidase 1ENSG0000016430727
NPEPPS / P55786 / aminopeptidase puromycin sensitiveENSG0000014127926


Protein motifs (from Interpro)
Interpro ID Name
 IPR001930  Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
 IPR014782  Peptidase M1, membrane alanine aminopeptidase, N-terminal
 IPR015570  Pyroglutamyl-peptidase II
 IPR024571  ERAP1-like C-terminal domain
 IPR034016  Aminopeptidase N-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0008217 regulation of blood pressure IBA
 biological_processGO:0043171 peptide catabolic process IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004177 aminopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042277 peptide binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070006 metalloaminopeptidase activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr