ENSG00000113441


Homo sapiens

Features
Gene ID: ENSG00000113441
  
Biological name :LNPEP
  
Synonyms : leucyl and cystinyl aminopeptidase / LNPEP / Q9UIQ6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q15
Gene start: 96935394
Gene end: 97037515
  
Corresponding Affymetrix probe sets: 207904_s_at (Human Genome U133 Plus 2.0 Array)   225176_at (Human Genome U133 Plus 2.0 Array)   231866_at (Human Genome U133 Plus 2.0 Array)   236728_at (Human Genome U133 Plus 2.0 Array)   243532_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000231368
Ensembl peptide - ENSP00000379117
NCBI entrez gene - 4012     See in Manteia.
OMIM - 151300
RefSeq - NM_005575
RefSeq - NM_175920
RefSeq Peptide - NP_005566
RefSeq Peptide - NP_787116
swissprot - Q9UIQ6
Ensembl - ENSG00000113441
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lnpepENSDARG00000100394Danio rerio
 LNPEPENSGALG00000015301Gallus gallus
 LnpepENSMUSG00000023845Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ERAP1 / Q9NZ08 / endoplasmic reticulum aminopeptidase 1ENSG0000016430741
ERAP2 / Q6P179 / endoplasmic reticulum aminopeptidase 2ENSG0000016430840
TRHDE / Q9UKU6 / thyrotropin releasing hormone degrading enzymeENSG0000007265729
ANPEP / P15144 / alanyl aminopeptidase, membraneENSG0000016682529
ENPEP / Q07075 / glutamyl aminopeptidaseENSG0000013879229
NPEPPS / P55786 / aminopeptidase puromycin sensitiveENSG0000014127926
LVRN / Q6Q4G3 / laeverinENSG0000017290125


Protein motifs (from Interpro)
Interpro ID Name
 IPR001930  Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
 IPR014782  Peptidase M1, membrane alanine aminopeptidase, N-terminal
 IPR024571  ERAP1-like C-terminal domain
 IPR034016  Aminopeptidase N-type
 IPR034017  Cystinyl aminopeptidase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent TAS
 biological_processGO:0006508 proteolysis TAS
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007565 female pregnancy TAS
 biological_processGO:0008217 regulation of blood pressure IBA
 biological_processGO:0030163 protein catabolic process IEA
 biological_processGO:0043171 peptide catabolic process IBA
 biological_processGO:0060395 SMAD protein signal transduction IEA
 biological_processGO:0061024 membrane organization TAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005765 lysosomal membrane HDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane TAS
 cellular_componentGO:0031905 early endosome lumen TAS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004177 aminopeptidase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity TAS
 molecular_functionGO:0008270 zinc ion binding TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042277 peptide binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070006 metalloaminopeptidase activity IBA


Pathways (from Reactome)
Pathway description
Endosomal/Vacuolar pathway
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000136111 O60343 / TBC1D4 / TBC1 domain family member 4  / complex
 ENSG00000166710 B2M / P61769 / beta-2-microglobulin  / complex






 

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