ENSMUSG00000021583


Mus musculus

Features
Gene ID: ENSMUSG00000021583
  
Biological name :Erap1
  
Synonyms : Endoplasmic reticulum aminopeptidase 1 / Erap1 / Q9EQH2
  
Possible biological names infered from orthology : Q9NZ08
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: C1
Gene start: 74639568
Gene end: 74693201
  
Corresponding Affymetrix probe sets: 10406205 (MoGene1.0st)   1416942_at (Mouse Genome 430 2.0 Array)   1439068_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133166
Ensembl peptide - ENSMUSP00000152705
Ensembl peptide - ENSMUSP00000152462
Ensembl peptide - ENSMUSP00000152076
NCBI entrez gene - 80898     See in Manteia.
MGI - MGI:1933403
RefSeq - XM_006517476
RefSeq - NM_030711
RefSeq Peptide - NP_109636
swissprot - A0A1Y7VNJ8
swissprot - A0A1Y7VNY4
swissprot - Q9EQH2
swissprot - A0A1Y7VMT6
Ensembl - ENSMUSG00000021583
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 erap1aENSDARG00000013024Danio rerio
 erap1bENSDARG00000021859Danio rerio
 ERAP1ENSGALG00000014684Gallus gallus
 ERAP1ENSG00000164307Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lnpep / Q8C129 / Leucyl-cystinyl aminopeptidase / Q9UIQ6* / leucyl and cystinyl aminopeptidase*ENSMUSG0000002384545
Enpep / P16406 / glutamyl aminopeptidase / Q07075*ENSMUSG0000002802432
Trhde / Q8K093 / Thyrotropin-releasing hormone-degrading ectoenzyme / Q9UKU6* / thyrotropin releasing hormone degrading enzyme*ENSMUSG0000005066332
Anpep / P97449 / Aminopeptidase N / P15144* / alanyl aminopeptidase, membrane*ENSMUSG0000003906231
Npepps / Q11011 / Puromycin-sensitive aminopeptidase / P55786* / aminopeptidase puromycin sensitive*ENSMUSG0000000144131
Lvrn / laeverin / Q6Q4G3*ENSMUSG0000002448128


Protein motifs (from Interpro)
Interpro ID Name
 IPR001930  Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
 IPR014782  Peptidase M1, membrane alanine aminopeptidase, N-terminal
 IPR024571  ERAP1-like C-terminal domain
 IPR033520  Endoplasmic reticulum aninopeptidase 1
 IPR034016  Aminopeptidase N-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006509 membrane protein ectodomain proteolysis IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I IEA
 biological_processGO:0043171 peptide catabolic process IBA
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004175 endopeptidase activity ISO
 molecular_functionGO:0004177 aminopeptidase activity ISO
 molecular_functionGO:0005138 interleukin-6 receptor binding IEA
 molecular_functionGO:0008233 peptidase activity IMP
 molecular_functionGO:0008235 metalloexopeptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042277 peptide binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070006 metalloaminopeptidase activity IEA


Pathways (from Reactome)
Pathway description
Antigen Presentation: Folding, assembly and peptide loading of class I MHC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Twsg1tm1Dgen/Twsg1tm1Dgen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Twsg1tm1Dgen/Twsg1tm1Dgen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000708 thymus hyperplasia "increased cell number in the thymus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Twsg1tm1Dgen/Twsg1tm1Dgen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001835 abnormal antigen presentation "aberration in the process by which peptide is presented to lymphocytes in a form they can recognize " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc27a4tm1.1Wsr/Slc27a4tm1.1Wsr
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ

Allelic Composition: Erap1tm1Luc/Erap1+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Erap1tm1.1Gnie/Erap1tm1.1Gnie
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001836 abnormal antigen presentation via MHC class I "anomaly in the process by which peptide, bound to major histocompatibility complex class I, is presented to lymphocytes at the surface of antigen presenting cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Btlatm1Kmm/Btlatm1Kmm,Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic Background: B6.129S-Pdcd1tm1Hon Btlatm1Kmm

Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha
Genetic Background: B6.129S6-Erap1tm1Nsha

Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/10 * DBA/2

 MP:0001840 increased level of surface class I molecule "greater than normal expression of major histocompatibility complex class I molecules at the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Erap1tm1Luc/Erap1tm1Luc
Genetic Background: involves: 129S6/SvEvTac

 MP:0001841 decreased level of surface class I molecule "reduced expression of major histocompatibility complex class I molecules at the cell surface " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kcnd2tm1Jmn/Kcnd2tm1Jmn
Genetic Background: FVB.129-Kcnd2tm1Jmn

Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha
Genetic Background: B6.129S6-Erap1tm1Nsha

Allelic Composition: Erap1tm1Luc/Erap1tm1Luc
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Erap1tm1Luc/Erap1+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Erap1tm1.1Gnie/Erap1tm1.1Gnie
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha
Genetic Background: B6.129S6-Erap1tm1Nsha

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
Show

Allelic Composition: Twsg1tm1Dgen/Twsg1tm1Dgen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Erap1tm1Luc/Erap1tm1Luc
Genetic Background: involves: 129S6/SvEvTac

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Erap1tm1Nsha/Erap1tm1Nsha
Genetic Background: B6.129S6-Erap1tm1Nsha

Allelic Composition: Erap1tm1Luc/Erap1tm1Luc
Genetic Background: involves: 129S6/SvEvTac

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Erap1tm1.1Gnie/Erap1tm1.1Gnie
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kcnd2tm1Jmn/Kcnd2tm1Jmn
Genetic Background: FVB.129-Kcnd2tm1Jmn

Allelic Composition: Erap1tm1.1Gnie/Erap1tm1.1Gnie
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Erap1tm1.1Gnie/Erap1tm1.1Gnie
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Erap1tm1.1Gnie/Erap1tm1.1Gnie
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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