ENSDARG00000021859


Danio rerio

Features
Gene ID: ENSDARG00000021859
  
Biological name :erap1b
  
Synonyms : endoplasmic reticulum aminopeptidase 1b / erap1b
  
Possible biological names infered from orthology : endoplasmic reticulum aminopeptidase 1 / ERAP1 / Q9EQH2 / Q9NZ08
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 26234425
Gene end: 26247973
  
Corresponding Affymetrix probe sets: Dr.26122.1.A1_at (Zebrafish Array)   NM_200206_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000089298
Ensembl peptide - ENSDARP00000121960
Ensembl peptide - ENSDARP00000115928
NCBI entrez gene - 393175     See in Manteia.
RefSeq - NM_200206
RefSeq Peptide - NP_956500
swissprot - A2BGR0
swissprot - A2BGQ9
swissprot - F1QFR6
ZFIN ID - ZDB-GENE-040426-934
Ensembl - ENSDARG00000021859
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ERAP1ENSGALG00000014684Gallus gallus
 ERAP1ENSG00000164307Homo sapiens
 Erap1ENSMUSG00000021583Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
erap1a / endoplasmic reticulum aminopeptidase 1a / ERAP1* / Q9EQH2* / Q9NZ08* / endoplasmic reticulum aminopeptidase 1*ENSDARG0000001302466
erap2 / endoplasmic reticulum aminopeptidase 2 / Q6P179*ENSDARG0000009861850
lnpep / leucyl/cystinyl aminopeptidase / Q9UIQ6* / leucyl and cystinyl aminopeptidase*ENSDARG0000010039442
anpepb / alanyl (membrane) aminopeptidase b / ANPEP* / P97449* / P15144* / Aminopeptidase N * / alanyl aminopeptidase, membrane*ENSDARG0000010387831
enpep / glutamyl aminopeptidase / P16406* / Q07075*ENSDARG0000005706430
si:ch211-147g22.5 / ANPEP* / P15144* / P97449* / Aminopeptidase N * / alanyl aminopeptidase, membrane*ENSDARG0000009728529
si:ch211-106j24.1 / ANPEP* / P15144* / P97449* / Aminopeptidase N * / alanyl aminopeptidase, membrane*ENSDARG0000003680929
trhde.2 / trhde.1 / thyrotropin releasing hormone degrading enzyme, tandem duplicate 2 / TRHDE* / Q8K093* / Q9UKU6* / thyrotropin releasing hormone degrading enzyme* / Thyrotropin-releasing...ENSDARG0000011183729
trhde.2 / trhde.1 / thyrotropin releasing hormone degrading enzyme, tandem duplicate 1 / TRHDE* / Q8K093* / Q9UKU6* / thyrotropin releasing hormone degrading enzyme* / Thyrotropin-releasing...ENSDARG0000010935829
npepps / aminopeptidase puromycin sensitive / P55786* / Q11011* / Puromycin-sensitive aminopeptidase *ENSDARG0000004494328
ANPEP / si:ch211-276a23.5 / P15144* / P97449* / Aminopeptidase N * / alanyl aminopeptidase, membrane*ENSDARG0000008970628
anpepa / alanyl (membrane) aminopeptidase aENSDARG0000004108326


Protein motifs (from Interpro)
Interpro ID Name
 IPR001930  Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
 IPR014782  Peptidase M1, membrane alanine aminopeptidase, N-terminal
 IPR024571  ERAP1-like C-terminal domain
 IPR033520  Endoplasmic reticulum aninopeptidase 1
 IPR034016  Aminopeptidase N-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I IEA
 biological_processGO:0043171 peptide catabolic process IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IBA
 molecular_functionGO:0004177 aminopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042277 peptide binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070006 metalloaminopeptidase activity IEA


Pathways (from Reactome)
Pathway description
Antigen Presentation: Folding, assembly and peptide loading of class I MHC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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