ENSGALG00000014684


Gallus gallus

Features
Gene ID: ENSGALG00000014684
  
Biological name :ERAP1
  
Synonyms : endoplasmic reticulum aminopeptidase 1 / ERAP1
  
Possible biological names infered from orthology : Q9EQH2 / Q9NZ08
  
Species: Gallus gallus
  
Chr. number: Z
Strand: 1
Band:
Gene start: 57003242
Gene end: 57017676
  
Corresponding Affymetrix probe sets: Gga.1140.1.S1_at (Chicken Array)   GgaAffx.24485.1.S1_at (Chicken Array)   GgaAffx.24485.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000023617
Ensembl peptide - ENSGALP00000062810
NCBI entrez gene - 427122     See in Manteia.
RefSeq - XM_001232417
swissprot - F1NB92
swissprot - Q5F3N8
Ensembl - ENSGALG00000014684
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 erap1aENSDARG00000013024Danio rerio
 erap1bENSDARG00000021859Danio rerio
 ERAP1ENSG00000164307Homo sapiens
 Erap1ENSMUSG00000021583Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LNPEP / leucyl and cystinyl aminopeptidase / Q8C129* / Q9UIQ6* / Leucyl-cystinyl aminopeptidase *ENSGALG0000001530146
ENPEP / glutamyl aminopeptidase / P16406* / Q07075*ENSGALG0000003141032
ANPEP / O57579 / Aminopeptidase Ey / P97449* / P15144* / Aminopeptidase N * / alanyl aminopeptidase, membrane*ENSGALG0000002750131
TRHDE / thyrotropin releasing hormone degrading enzyme / Q8K093* / Q9UKU6* / Thyrotropin-releasing hormone-degrading ectoenzyme *ENSGALG0000001020030
LVRN / laeverin / Q6Q4G3*ENSGALG0000000231827
NPEPPS / aminopeptidase puromycin sensitive / P55786* / Q11011* / Puromycin-sensitive aminopeptidase *ENSGALG0000003133219


Protein motifs (from Interpro)
Interpro ID Name
 IPR001930  Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
 IPR014782  Peptidase M1, membrane alanine aminopeptidase, N-terminal
 IPR024571  ERAP1-like C-terminal domain
 IPR033520  Endoplasmic reticulum aninopeptidase 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IBA
 biological_processGO:0006509 membrane protein ectodomain proteolysis IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0008217 regulation of blood pressure IBA
 biological_processGO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I IEA
 biological_processGO:0043171 peptide catabolic process IBA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IBA
 molecular_functionGO:0004177 aminopeptidase activity IEA
 molecular_functionGO:0005138 interleukin-6 receptor binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008235 metalloexopeptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042277 peptide binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070006 metalloaminopeptidase activity IBA


Pathways (from Reactome)
Pathway description
Antigen Presentation: Folding, assembly and peptide loading of class I MHC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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