ENSMUSG00000025823


Mus musculus

Features
Gene ID: ENSMUSG00000025823
  
Biological name :Pdia4
  
Synonyms : Pdia4 / protein disulfide isomerase family A member 4
  
Possible biological names infered from orthology : P13667
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: B2.3
Gene start: 47796141
Gene end: 47813430
  
Corresponding Affymetrix probe sets: 10544525 (MoGene1.0st)   1416497_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000076521
NCBI entrez gene - 12304     See in Manteia.
MGI - MGI:104864
RefSeq - NM_009787
RefSeq Peptide - NP_033917
swissprot - A0A0R4J0Z1
Ensembl - ENSMUSG00000025823
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdia4ENSDARG00000018491Danio rerio
 PDIA4ENSGALG00000043006Gallus gallus
 PDIA4ENSG00000155660Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pdia3 / P27773 / Protein disulfide-isomerase A3 / P30101* / protein disulfide isomerase family A member 3*ENSMUSG0000002724831
P4hb / P09103 / prolyl 4-hydroxylase, beta polypeptide / P07237* / prolyl 4-hydroxylase subunit beta*ENSMUSG0000002513025
Pdia2 / D3Z6P0 / Protein disulfide-isomerase A2 / Q13087* / protein disulfide isomerase family A member 2*ENSMUSG0000002418424
Pdilt / Q9DAN1 / Protein disulfide-isomerase-like protein of the testis / Q8N807* / protein disulfide isomerase like, testis expressed*ENSMUSG0000003096817
Erp44 / Q9D1Q6 / Endoplasmic reticulum resident protein 44 / Q9BS26* / endoplasmic reticulum protein 44*ENSMUSG0000002834314
Tmx3 / Q8BXZ1 / Protein disulfide-isomerase TMX3 / Q96JJ7* / thioredoxin related transmembrane protein 3*ENSMUSG0000002461413
Erp27 / Q9D8U3 / Endoplasmic reticulum resident protein 27 / Q96DN0* / endoplasmic reticulum protein 27*ENSMUSG000000302197


Protein motifs (from Interpro)
Interpro ID Name
 IPR005788  Disulphide isomerase
 IPR005792  Protein disulphide isomerase
 IPR013766  Thioredoxin domain
 IPR017068  Protein disulphide-isomerase A4
 IPR017937  Thioredoxin, conserved site
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen IEA
 cellular_componentGO:0009986 cell surface IEA
 molecular_functionGO:0003756 protein disulfide isomerase activity IEA
 molecular_functionGO:0015037 peptide disulfide oxidoreductase activity IEA
 molecular_functionGO:0016853 isomerase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Muttm1Pai/Muttm1.1Mrb
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009448 decreased platelet ATP level "reduced concentration of the major energy source adenosine triphosphate produced by dense bodies located in platelets" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Muttm1Pai/Muttm1.1Mrb
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
Show

Allelic Composition: Muttm1Pai/Muttm1.1Mrb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Pdia4tm1b(EUCOMM)Wtsi/Pdia4tm1b(EUCOMM)Wtsi,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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