Manteia

ENSMUSG00000025130

Mus musculus

Features

Gene ID:	ENSMUSG00000025130

Biological name :	P4hb

Synonyms :	P09103 / P4hb / prolyl 4-hydroxylase, beta polypeptide

Possible biological names infered from orthology :	P07237 / prolyl 4-hydroxylase subunit beta

Species:	Mus musculus

Chr. number:	11
Strand:	-1
Band:	E2
Gene start:	120560298
Gene end:	120573253

Corresponding Affymetrix probe sets:	10393823 (MoGene1.0st) 1437465_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000128796 Ensembl peptide - ENSMUSP00000026122 NCBI entrez gene - 18453 See in Manteia. MGI - MGI:97464 RefSeq - NM_011032 RefSeq Peptide - NP_035162 swissprot - E9Q8G8 swissprot - P09103 Ensembl - ENSMUSG00000025130

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
p4hb	ENSDARG00000105116	Danio rerio
P4HB	ENSGALG00000038290	Gallus gallus
P4HB	ENSG00000185624	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Pdia2 / D3Z6P0 / Protein disulfide-isomerase A2 / Q13087* / protein disulfide isomerase family A member 2*	ENSMUSG00000024184	46
Pdia3 / P27773 / Protein disulfide-isomerase A3 / P30101* / protein disulfide isomerase family A member 3*	ENSMUSG00000027248	31
Pdia4 / protein disulfide isomerase family A member 4 / P13667*	ENSMUSG00000025823	31
Pdilt / Q9DAN1 / Protein disulfide-isomerase-like protein of the testis / Q8N807* / protein disulfide isomerase like, testis expressed*	ENSMUSG00000030968	31
Erp44 / Q9D1Q6 / Endoplasmic reticulum resident protein 44 / Q9BS26* / endoplasmic reticulum protein 44*	ENSMUSG00000028343	18
Tmx3 / Q8BXZ1 / Protein disulfide-isomerase TMX3 / Q96JJ7* / thioredoxin related transmembrane protein 3*	ENSMUSG00000024614	18
Erp27 / Q9D8U3 / Endoplasmic reticulum resident protein 27 / Q96DN0* / endoplasmic reticulum protein 27*	ENSMUSG00000030219	16

Protein motifs (from Interpro)

Interpro ID	Name
IPR005788	Disulphide isomerase
IPR005792	Protein disulphide isomerase
IPR013766	Thioredoxin domain
IPR017937	Thioredoxin, conserved site
IPR036249	Thioredoxin-like superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006457	protein folding	IBA
biological_process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	ISO
biological_process	GO:0034976	response to endoplasmic reticulum stress	IEA
biological_process	GO:0045454	cell redox homeostasis	IEA
biological_process	GO:0046598	positive regulation of viral entry into host cell	IEA
biological_process	GO:0055114	oxidation-reduction process	IEA
biological_process	GO:0071456	cellular response to hypoxia	IEA
biological_process	GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IEA
cellular_component	GO:0005783	endoplasmic reticulum	ISO
cellular_component	GO:0005788	endoplasmic reticulum lumen	IEA
cellular_component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0009897	external side of plasma membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016222	procollagen-proline 4-dioxygenase complex	IEA
cellular_component	GO:0031012	extracellular matrix	ISO
cellular_component	GO:0034663	endoplasmic reticulum chaperone complex	IDA
cellular_component	GO:0042470	melanosome	IEA
molecular_function	GO:0003756	protein disulfide isomerase activity	IBA
molecular_function	GO:0004656	procollagen-proline 4-dioxygenase activity	IEA
molecular_function	GO:0005178	integrin binding	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0015037	peptide disulfide oxidoreductase activity	IEA
molecular_function	GO:0016853	isomerase activity	IEA
molecular_function	GO:0019899	enzyme binding	IEA
molecular_function	GO:0031545	peptidyl-proline 4-dioxygenase activity	IBA
molecular_function	GO:0046982	protein heterodimerization activity	IEA

Pathways (from Reactome)

Pathway description

Collagen biosynthesis and modifying enzymes

Detoxification of Reactive Oxygen Species

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Hedgehog ligand biogenesis

VLDL assembly

Post-translational protein phosphorylation

Chylomicron assembly

Interleukin-12 signaling

Interleukin-23 signaling

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000222	decreased neutrophil count	"fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gabrg2^{tm1.1(Gabrg2)Wwis}/Gabrg2^{tm1.1(Gabrg2)Wwis} Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0008719	impaired neutrophil recruitment	"reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: P4hb^tm1.1Geno/P4hb^tm1.2Geno,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Otub1^{tm1b(EUCOMM)Hmgu}/Otub1^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Otub1^{tm1b(EUCOMM)Hmgu}/H

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000002633	Shh / Q62226 / Sonic hedgehog protein Sonic hedgehog protein N-product / Q15465* / sonic hedgehog*	/ reaction / complex
ENSMUSG00000019916	P4ha1 / Q60715 / Prolyl 4-hydroxylase subunit alpha-1 / P13674*	/ reaction / complex
ENSMUSG00000018906	P4ha2 / Q60716 / Prolyl 4-hydroxylase subunit alpha-2 / O15460*	/ reaction / complex
ENSMUSG00000001506	Col1a1 / P11087 / Collagen alpha-1(I) chain / P02452* / collagen type I alpha 1 chain*	/ reaction / complex
ENSMUSG00000025130	P4hb / P09103 / prolyl 4-hydroxylase, beta polypeptide / P07237* / prolyl 4-hydroxylase subunit beta*	/ complex / reaction
ENSMUSG00000004296	Il12b / P43432 / Interleukin-12 subunit beta / P29460* / interleukin 12B*	/ reaction
ENSMUSG00000028158	Mttp / O08601 / Microsomal triglyceride transfer protein large subunit / P55157* / microsomal triglyceride transfer protein*	/ complex
ENSMUSG00000029661	Col1a2 / Q01149 / Collagen alpha-2(I) chain / P08123* / collagen type I alpha 2 chain*	/ complex / reaction
ENSMUSG00000026043	Col3a1 / P08121 / Collagen alpha-1(III) chain / P02461* / collagen type III alpha 1 chain*	/ reaction / complex
ENSMUSG00000039462	Q05306 / Col10a1 / Collagen alpha-1(X) chain / Q03692* / collagen type X alpha 1 chain*	/ complex / reaction
ENSMUSG00000051048	P4ha3 / prolyl 4-hydroxylase subunit alpha 3 / Q7Z4N8*	/ complex / reaction
ENSMUSG00000021760	Gpx8 / Q9D7B7 / Probable glutathione peroxidase 8 / Q8TED1* / glutathione peroxidase 8 (putative)*	/ reaction
ENSMUSG00000028597	Gpx7 / Q99LJ6 / Glutathione peroxidase 7 / Q96SL4*	/ reaction

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr