ENSMUSG00000026043


Mus musculus

Features
Gene ID: ENSMUSG00000026043
  
Biological name :Col3a1
  
Synonyms : Col3a1 / Collagen alpha-1(III) chain / P08121
  
Possible biological names infered from orthology : collagen type III alpha 1 chain / P02461
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C1.1
Gene start: 45311538
Gene end: 45349706
  
Corresponding Affymetrix probe sets: 10346015 (MoGene1.0st)   1427883_a_at (Mouse Genome 430 2.0 Array)   1427884_at (Mouse Genome 430 2.0 Array)   1442977_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000085192
Ensembl peptide - ENSMUSP00000139894
Ensembl peptide - ENSMUSP00000139802
NCBI entrez gene - 12825     See in Manteia.
MGI - MGI:88453
RefSeq - NM_009930
RefSeq Peptide - NP_034060
swissprot - A0A087WPJ5
swissprot - A0A087WPS3
swissprot - P08121
swissprot - Q3TVI5
Ensembl - ENSMUSG00000026043
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 COL3A1ENSGALG00000035584Gallus gallus
 COL3A1ENSG00000168542Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Col2a1 / P28481 / Collagen alpha-1(II) chain Collagen alpha-1(II) chain Chondrocalcin / P02458* / collagen type II alpha 1 chain*ENSMUSG0000002248361
Col1a1 / P11087 / Collagen alpha-1(I) chain / P02452* / collagen type I alpha 1 chain*ENSMUSG0000000150661
Col5a2 / Q3U962 / Collagen alpha-2(V) chain / P05997* / collagen type V alpha 2 chain*ENSMUSG0000002604255
Col1a2 / Q01149 / Collagen alpha-2(I) chain / P08123* / collagen type I alpha 2 chain*ENSMUSG0000002966152
Q61245 / Col11a1 / Collagen alpha-1(XI) chain / P12107* / collagen type XI alpha 1 chain*ENSMUSG0000002796644
Col5a1 / O88207 / Collagen alpha-1(V) chain / P20908* / collagen type V alpha 1 chain*ENSMUSG0000002683744
Q64739 / Col11a2 / Collagen alpha-2(XI) chain / P13942* / collagen type XI alpha 2 chain*ENSMUSG0000002433043
Col5a3 / collagen, type V, alpha 3 / P25940* / collagen type V alpha 3 chain*ENSMUSG0000000409842
Q5QNQ9 / Col27a1 / Collagen alpha-1(XXVII) chain / Q8IZC6* / collagen type XXVII alpha 1 chain*ENSMUSG0000004567237
Q30D77 / Col24a1 / Collagen alpha-1(XXIV) chain / Q17RW2* / collagen type XXIV alpha 1 chain*ENSMUSG0000002819735


Protein motifs (from Interpro)
Interpro ID Name
 IPR000885  Fibrillar collagen, C-terminal
 IPR001007  VWFC domain
 IPR008160  Collagen triple helix repeat
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR016133  Insect cysteine-rich antifreeze protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IEA
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0018149 peptide cross-linking IEA
 biological_processGO:0021987 cerebral cortex development IMP
 biological_processGO:0030199 collagen fibril organization IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0035025 positive regulation of Rho protein signal transduction IDA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0043588 skin development IEA
 biological_processGO:0048565 digestive tract development IMP
 biological_processGO:0050777 negative regulation of immune response IEA
 biological_processGO:0060414 aorta smooth muscle tissue morphogenesis IMP
 biological_processGO:0071230 cellular response to amino acid stimulus IDA
 biological_processGO:0097435 supramolecular fiber organization IEA
 biological_processGO:2001223 negative regulation of neuron migration IMP
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005586 collagen type III trimer IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005201 extracellular matrix structural constituent IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0046332 SMAD binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048407 platelet-derived growth factor binding IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Extracellular matrix organization
Collagen biosynthesis and modifying enzymes
Signaling by PDGF
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
NCAM1 interactions
MET activates PTK2 signaling
Collagen chain trimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001198 tight skin "skin has a taut, stretched appearance" [J:65038]
Show

Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
Show

Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001245 thick dermal layer "increased depth of the dermis" [J:65033]
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Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Col3a1m1Lsmi/Col3a1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Col3a1m1Lsmi/Col3a1+
Genetic Background: involves: 129P2/OlaHsd * C3H/HeH * C57BL/6J

Allelic Composition: Col3a1m1Lsmi/Col3a1+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0003025 increased vascular smooth muscle contraction "greater ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Col3a1m1Lsmi/Col3a1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col3a1m1Lsmi/Col3a1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004044 aortic dissection "a pathologic process, characterized by splitting of the media layer of the aorta, which leads to formation of a dissecting aneurysm" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Col3a1m1Lsmi/Col3a1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Col3a1m1Lsmi/Col3a1+
Genetic Background: involves: 129P2/OlaHsd * C3H/HeH * C57BL/6J

Allelic Composition: Col3a1m1Lsmi/Col3a1+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Col3a1m1Lsmi/Col3a1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008438 abnormal cutaneous collagen fibril morphology "any structural anomaly of the connective tissue bundles in the extracellular matrix of skin tissue that are composed of collagen, and play a role in skin strength and elasticity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0009862 abnormal aorta elastic tissue morphology "any structural anomaly of the dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col3a1m1Lsmi/Col3a1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009865 abnormal aorta smooth muscle morphology "any structural anomaly of the nonstriated, involuntary muscle tissue located in the wall of the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col3a1m1Lsmi/Col3a1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009866 abnormal aorta wall morphology "any structural anomaly of the part of the aorta that encloses the luminal space" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0009932 skin fibrosis "invasion of fibrous connective tissue into the skin, often resulting from inflammation or injury" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010546 abnormal subendocardium layer morphology "any structural anomaly of the layer of loose fibrous tissue located between the endocardium and myocardium which contains the nerves and the impulse-conducting system (Purkinje fibers) of the heart" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Sgk3fz-4J/Sgk3fz-4J
Genetic Background: involves: C57BL/6J

 MP:0020386 adipose tissue inflammation "local accumulation of fluid, plasma proteins, and leukocytes in adipose tissue" [MGI:anna, PMID:24662293, PMID:24695736, PMID:26629401]
Show

Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019916 P4ha1 / Q60715 / Prolyl 4-hydroxylase subunit alpha-1 / P13674*  / reaction
 ENSMUSG00000018906 P4ha2 / Q60716 / Prolyl 4-hydroxylase subunit alpha-2 / O15460*  / reaction
 ENSMUSG00000025130 P4hb / P09103 / prolyl 4-hydroxylase, beta polypeptide / P07237* / prolyl 4-hydroxylase subunit beta*  / complex / reaction
 ENSMUSG00000051048 P4ha3 / prolyl 4-hydroxylase subunit alpha 3 / Q7Z4N8*  / reaction






 

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