ENSMUSG00000018906


Mus musculus

Features
Gene ID: ENSMUSG00000018906
  
Biological name :P4ha2
  
Synonyms : P4ha2 / Prolyl 4-hydroxylase subunit alpha-2 / Q60716
  
Possible biological names infered from orthology : O15460
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B1.3
Gene start: 54100095
Gene end: 54131665
  
Corresponding Affymetrix probe sets: 10376074 (MoGene1.0st)   1417149_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118608
Ensembl peptide - ENSMUSP00000133275
Ensembl peptide - ENSMUSP00000121955
Ensembl peptide - ENSMUSP00000121543
Ensembl peptide - ENSMUSP00000121119
Ensembl peptide - ENSMUSP00000119861
Ensembl peptide - ENSMUSP00000019050
Ensembl peptide - ENSMUSP00000091749
Ensembl peptide - ENSMUSP00000115245
Ensembl peptide - ENSMUSP00000118384
NCBI entrez gene - 18452     See in Manteia.
MGI - MGI:894286
RefSeq - XM_006532452
RefSeq - NM_001136076
RefSeq - NM_011031
RefSeq Peptide - NP_035161
RefSeq Peptide - NP_001129548
swissprot - B0QZH3
swissprot - Q60716
swissprot - D6RCG8
swissprot - Q5SX74
swissprot - Q5SX75
swissprot - Q5SX76
swissprot - B0QZH2
swissprot - B0QZH0
swissprot - B0QZH1
swissprot - F6ULE1
Ensembl - ENSMUSG00000018906
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 p4ha2ENSDARG00000010085Danio rerio
 P4HA2ENSGALG00000006677Gallus gallus
 P4HA2ENSG00000072682Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P4ha1 / Q60715 / Prolyl 4-hydroxylase subunit alpha-1 / P13674*ENSMUSG0000001991661
P4ha3 / prolyl 4-hydroxylase subunit alpha 3 / Q7Z4N8*ENSMUSG0000005104836


Protein motifs (from Interpro)
Interpro ID Name
 IPR005123  Oxoglutarate/iron-dependent dioxygenase
 IPR006620  Prolyl 4-hydroxylase, alpha subunit
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR013547  Prolyl 4-hydroxylase alpha-subunit, N-terminal
 IPR019734  Tetratricopeptide repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline IDA
 biological_processGO:0019511 peptidyl-proline hydroxylation IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016222 procollagen-proline 4-dioxygenase complex IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0004656 procollagen-proline 4-dioxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0031418 L-ascorbic acid binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Collagen biosynthesis and modifying enzymes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019916 P4ha1 / Q60715 / Prolyl 4-hydroxylase subunit alpha-1 / P13674*  / complex
 ENSMUSG00000029661 Col1a2 / Q01149 / Collagen alpha-2(I) chain / P08123* / collagen type I alpha 2 chain*  / reaction
 ENSMUSG00000026043 Col3a1 / P08121 / Collagen alpha-1(III) chain / P02461* / collagen type III alpha 1 chain*  / reaction
 ENSMUSG00000018906 P4ha2 / Q60716 / Prolyl 4-hydroxylase subunit alpha-2 / O15460*  / complex
 ENSMUSG00000039462 Q05306 / Col10a1 / Collagen alpha-1(X) chain / Q03692* / collagen type X alpha 1 chain*  / reaction
 ENSMUSG00000025130 P4hb / P09103 / prolyl 4-hydroxylase, beta polypeptide / P07237* / prolyl 4-hydroxylase subunit beta*  / reaction / complex
 ENSMUSG00000001506 Col1a1 / P11087 / Collagen alpha-1(I) chain / P02452* / collagen type I alpha 1 chain*  / reaction
 ENSMUSG00000051048 P4ha3 / prolyl 4-hydroxylase subunit alpha 3 / Q7Z4N8*  / complex






 

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