ENSDARG00000010085


Danio rerio

Features
Gene ID: ENSDARG00000010085
  
Biological name :p4ha2
  
Synonyms : p4ha2 / procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2
  
Possible biological names infered from orthology : O15460 / prolyl 4-hydroxylase subunit alpha 2 / Q60716
  
Species: Danio rerio
  
Chr. number: 21
Strand: -1
Band:
Gene start: 43097798
Gene end: 43131752
  
Corresponding Affymetrix probe sets: Dr.19144.1.A1_at (Zebrafish Array)   NM_001007285_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000109880
Ensembl peptide - ENSDARP00000143396
Ensembl peptide - ENSDARP00000135715
Ensembl peptide - ENSDARP00000027028
NCBI entrez gene - 373132     See in Manteia.
RefSeq - NM_001007285
RefSeq Peptide - NP_001007286
swissprot - A0A0R4IKZ3
swissprot - F1QCU6
swissprot - A0A286Y8C8
swissprot - Q6DG45
ZFIN ID - ZDB-GENE-030827-1
Ensembl - ENSDARG00000010085
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P4HA2ENSGALG00000006677Gallus gallus
 P4HA2ENSG00000072682Homo sapiens
 P4ha2ENSMUSG00000018906Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
p4ha1b / prolyl 4-hydroxylase, alpha polypeptide I b / P4HA1* / P13674* / Q60715* / prolyl 4-hydroxylase subunit alpha 1*ENSDARG0000007108264
p4ha1a / prolyl 4-hydroxylase, alpha polypeptide I a / P4HA1* / P13674* / Q60715* / prolyl 4-hydroxylase subunit alpha 1*ENSDARG0000003353764
si:ch73-68b22.2ENSDARG0000009460935
zgc:152670ENSDARG0000001703835
p4ha3 / prolyl 4-hydroxylase, alpha polypeptide III / Q7Z4N8* / prolyl 4-hydroxylase subunit alpha 3*ENSDARG0000010369234
si:cabz01069582.1 / P4HA3* / Q7Z4N8* / prolyl 4-hydroxylase subunit alpha 3*ENSDARG000001053499


Protein motifs (from Interpro)
Interpro ID Name
 IPR005123  Oxoglutarate/iron-dependent dioxygenase
 IPR006620  Prolyl 4-hydroxylase, alpha subunit
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR013547  Prolyl 4-hydroxylase alpha-subunit, N-terminal
 IPR019734  Tetratricopeptide repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0019511 peptidyl-proline hydroxylation IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 molecular_functionGO:0004656 procollagen-proline 4-dioxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0031418 L-ascorbic acid binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Collagen biosynthesis and modifying enzymes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000071082 p4ha1b / prolyl 4-hydroxylase, alpha polypeptide I b / P4HA1* / P13674* / Q60715* / prolyl 4-hydroxylase subunit alpha 1*  / complex
 ENSDARG00000010085 p4ha2 / procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2 / O15460* / prolyl 4-hydroxylase subunit alpha 2*  / complex
 ENSDARG00000033537 p4ha1a / prolyl 4-hydroxylase, alpha polypeptide I a / P4HA1* / P13674* / Q60715* / prolyl 4-hydroxylase subunit alpha 1*  / complex
 ENSDARG00000105116 p4hb / prolyl 4-hydroxylase, beta polypeptide / P07237* / P09103* / prolyl 4-hydroxylase subunit beta*  / reaction / complex
 ENSDARG00000101535 col10a1b / collagen, type X, alpha 1b / Q03692* / COL10A1* / collagen type X alpha 1 chain*  / reaction
 ENSDARG00000020007 col1a2 / collagen, type I, alpha 2 / Q01149* / P08123* / Collagen alpha-2(I) chain * / collagen type I alpha 2 chain*  / reaction






 

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