ENSDARG00000105116


Danio rerio

Features
Gene ID: ENSDARG00000105116
  
Biological name :p4hb
  
Synonyms : p4hb / prolyl 4-hydroxylase, beta polypeptide
  
Possible biological names infered from orthology : P07237 / P09103 / prolyl 4-hydroxylase subunit beta
  
Species: Danio rerio
  
Chr. number: 6
Strand: -1
Band:
Gene start: 18203464
Gene end: 18228358
  
Corresponding Affymetrix probe sets: NM_213364_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000138657
NCBI entrez gene - 406673     See in Manteia.
RefSeq - NM_213364
RefSeq Peptide - NP_998529
swissprot - A0A0R4ISX6
ZFIN ID - ZDB-GENE-080610-1
Ensembl - ENSDARG00000105116
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P4HBENSGALG00000038290Gallus gallus
 P4HBENSG00000185624Homo sapiens
 P4hbENSMUSG00000025130Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pdia2 / protein disulfide isomerase family A, member 2 / D3Z6P0* / Q13087* / Protein disulfide-isomerase A2 *ENSDARG0000001826346
zgc:136472 / PDILT* / Q9DAN1* / Q8N807* / protein disulfide isomerase like, testis expressed* / Protein disulfide-isomerase-like protein of the testis *ENSDARG0000005844535
pdia4 / protein disulfide isomerase family A, member 4 / P13667*ENSDARG0000001849131
zgc:77086ENSDARG0000001401531
zgc:100906ENSDARG0000003359930
pdia3 / protein disulfide isomerase family A, member 3 / P27773* / P30101* / Protein disulfide-isomerase A3 *ENSDARG0000010264029
erp44 / endoplasmic reticulum protein 44 / Q9BS26* / Q9D1Q6* / Endoplasmic reticulum resident protein 44 *ENSDARG0000001900817
tmx3a / thioredoxin related transmembrane protein 3a / TMX3* / Q8BXZ1* / Q96JJ7* / Protein disulfide-isomerase TMX3 * / thioredoxin related transmembrane protein 3*ENSDARG0000003889415
tmx3b / thioredoxin related transmembrane protein 3b / TMX3* / Q96JJ7* / thioredoxin related transmembrane protein 3*ENSDARG000000884667


Protein motifs (from Interpro)
Interpro ID Name
 IPR005788  Disulphide isomerase
 IPR005792  Protein disulphide isomerase
 IPR012336  Thioredoxin-like fold
 IPR013766  Thioredoxin domain
 IPR017937  Thioredoxin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0045454 cell redox homeostasis IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 molecular_functionGO:0003756 protein disulfide isomerase activity IEA
 molecular_functionGO:0016853 isomerase activity IEA


Pathways (from Reactome)
Pathway description
Collagen biosynthesis and modifying enzymes
Detoxification of Reactive Oxygen Species
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
VLDL assembly
Post-translational protein phosphorylation
Chylomicron assembly
Interleukin-12 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000008637 mttp / A0A0R4IVV0 / microsomal triglyceride transfer protein / P55157* / O08601* / Microsomal triglyceride transfer protein large subunit *  / complex
 ENSDARG00000010085 p4ha2 / procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2 / O15460* / prolyl 4-hydroxylase subunit alpha 2*  / reaction / complex
 ENSDARG00000033537 p4ha1a / prolyl 4-hydroxylase, alpha polypeptide I a / P4HA1* / P13674* / Q60715* / prolyl 4-hydroxylase subunit alpha 1*  / reaction / complex
 ENSDARG00000071082 p4ha1b / prolyl 4-hydroxylase, alpha polypeptide I b / P4HA1* / P13674* / Q60715* / prolyl 4-hydroxylase subunit alpha 1*  / reaction / complex
 ENSDARG00000105116 p4hb / prolyl 4-hydroxylase, beta polypeptide / P07237* / P09103* / prolyl 4-hydroxylase subunit beta*  / complex / reaction
 ENSDARG00000101535 col10a1b / collagen, type X, alpha 1b / Q03692* / COL10A1* / collagen type X alpha 1 chain*  / reaction / complex
 ENSDARG00000020007 col1a2 / collagen, type I, alpha 2 / Q01149* / P08123* / Collagen alpha-2(I) chain * / collagen type I alpha 2 chain*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr