ENSGALG00000038290


Gallus gallus

Features
Gene ID: ENSGALG00000038290
  
Biological name :P4HB
  
Synonyms : P4HB / protein disulfide-isomerase precursor
  
Possible biological names infered from orthology : P07237 / P09103 / prolyl 4-hydroxylase, beta polypeptide / prolyl 4-hydroxylase subunit beta
  
Species: Gallus gallus
  
Chr. number: 18
Strand: -1
Band:
Gene start: 10010615
Gene end: 10018970
  
Corresponding Affymetrix probe sets: Gga.4976.1.S1_at (Chicken Array)   GgaAffx.20192.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000056764
Ensembl peptide - ENSGALP00000064334
Ensembl peptide - ENSGALP00000059311
NCBI entrez gene - 374091     See in Manteia.
RefSeq - NM_001198710
RefSeq Peptide - NP_001185639
swissprot - A0A1L1RZP5
swissprot - A0A1L1RKM2
swissprot - A0A1D5PV06
Ensembl - ENSGALG00000038290
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 p4hbENSDARG00000105116Danio rerio
 P4HBENSG00000185624Homo sapiens
 P4hbENSMUSG00000025130Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDIA2 / protein disulfide isomerase family A member 2 / D3Z6P0* / Q13087* / Protein disulfide-isomerase A2 *ENSGALG0000004007044
PDILT / protein disulfide isomerase like, testis expressed / Q8N807* / Q9DAN1* / Protein disulfide-isomerase-like protein of the testis *ENSGALG0000000200635
PDIA4 / protein disulfide-isomerase A4 / P13667* / protein disulfide isomerase family A member 4*ENSGALG0000004300631
PDIA3 / Q8JG64 / Protein disulfide-isomerase A3 / P30101* / P27773* / protein disulfide isomerase family A member 3*ENSGALG0000000834831
ERP44 / endoplasmic reticulum protein 44 / Q9BS26* / Q9D1Q6* / Endoplasmic reticulum resident protein 44 *ENSGALG0000001345219
TMX3 / Gallus gallus thioredoxin related transmembrane protein 3 (TMX3), transcript variant 1, mRNA. / Q8BXZ1* / Q96JJ7* / Protein disulfide-isomerase TMX3 * / thioredoxin related transmemb...ENSGALG0000001375718
ERP27* / Q96DN0* / Q9D8U3* / endoplasmic reticulum protein 27* / Endoplasmic reticulum resident protein 27 *ENSGALG0000001173913


Protein motifs (from Interpro)
Interpro ID Name
 IPR005788  Disulphide isomerase
 IPR005792  Protein disulphide isomerase
 IPR012336  Thioredoxin-like fold
 IPR013766  Thioredoxin domain
 IPR017937  Thioredoxin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0046598 positive regulation of viral entry into host cell IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016222 procollagen-proline 4-dioxygenase complex IEA
 cellular_componentGO:0034663 endoplasmic reticulum chaperone complex IEA
 molecular_functionGO:0003756 protein disulfide isomerase activity IEA
 molecular_functionGO:0004656 procollagen-proline 4-dioxygenase activity IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0015037 peptide disulfide oxidoreductase activity IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Collagen biosynthesis and modifying enzymes
Detoxification of Reactive Oxygen Species
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Hedgehog ligand biogenesis
VLDL assembly
Post-translational protein phosphorylation
Chylomicron assembly
Interleukin-12 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000010633 GPX7 / glutathione peroxidase 7 / Q96SL4* / Q99LJ6*  / reaction
 ENSGALG00000026704 GPX8 / glutathione peroxidase 8 (putative) / Q8TED1* / Q9D7B7* / Probable glutathione peroxidase 8 *  / reaction
 ENSGALG00000009641 COL1A2 / P02467 / Collagen alpha-2(I) chain / P08123* / Q01149* / collagen type I alpha 2 chain*  / complex / reaction
 ENSGALG00000014965 COL10A1 / collagen type X alpha 1 chain / Q03692* / Q05306* / Collagen alpha-1(X) chain *  / reaction / complex






 

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