ENSMUSG00000051048


Mus musculus

Features
Gene ID: ENSMUSG00000051048
  
Biological name :P4ha3
  
Synonyms : P4ha3 / prolyl 4-hydroxylase subunit alpha 3
  
Possible biological names infered from orthology : Q7Z4N8
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E2
Gene start: 100285520
Gene end: 100319699
  
Corresponding Affymetrix probe sets: 10555323 (MoGene1.0st)   1446951_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000055297
Ensembl peptide - ENSMUSP00000117015
Ensembl peptide - ENSMUSP00000119159
NCBI entrez gene - 320452     See in Manteia.
MGI - MGI:2444049
RefSeq - XM_011241831
RefSeq - NM_177161
RefSeq - XM_006507944
RefSeq Peptide - NP_796135
swissprot - D6RFD3
swissprot - H7BX23
swissprot - F6R2A2
Ensembl - ENSMUSG00000051048
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 p4ha3ENSDARG00000103692Danio rerio
 si:cabz01069582.1ENSDARG00000105349Danio rerio
 P4HA3ENSGALG00000042030Gallus gallus
 P4HA3ENSG00000149380Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P4ha2 / Q60716 / Prolyl 4-hydroxylase subunit alpha-2 / O15460*ENSMUSG0000001890635
P4ha1 / Q60715 / Prolyl 4-hydroxylase subunit alpha-1 / P13674*ENSMUSG0000001991634


Protein motifs (from Interpro)
Interpro ID Name
 IPR005123  Oxoglutarate/iron-dependent dioxygenase
 IPR006620  Prolyl 4-hydroxylase, alpha subunit
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013547  Prolyl 4-hydroxylase alpha-subunit, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0019511 peptidyl-proline hydroxylation IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 molecular_functionGO:0004656 procollagen-proline 4-dioxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0031418 L-ascorbic acid binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Collagen biosynthesis and modifying enzymes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019916 P4ha1 / Q60715 / Prolyl 4-hydroxylase subunit alpha-1 / P13674*  / complex
 ENSMUSG00000025130 P4hb / P09103 / prolyl 4-hydroxylase, beta polypeptide / P07237* / prolyl 4-hydroxylase subunit beta*  / complex / reaction
 ENSMUSG00000029661 Col1a2 / Q01149 / Collagen alpha-2(I) chain / P08123* / collagen type I alpha 2 chain*  / reaction
 ENSMUSG00000018906 P4ha2 / Q60716 / Prolyl 4-hydroxylase subunit alpha-2 / O15460*  / complex
 ENSMUSG00000001506 Col1a1 / P11087 / Collagen alpha-1(I) chain / P02452* / collagen type I alpha 1 chain*  / reaction
 ENSMUSG00000051048 P4ha3 / prolyl 4-hydroxylase subunit alpha 3 / Q7Z4N8*  / complex
 ENSMUSG00000039462 Q05306 / Col10a1 / Collagen alpha-1(X) chain / Q03692* / collagen type X alpha 1 chain*  / reaction
 ENSMUSG00000026043 Col3a1 / P08121 / Collagen alpha-1(III) chain / P02461* / collagen type III alpha 1 chain*  / reaction






 

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