ENSG00000149380


Homo sapiens

Features
Gene ID: ENSG00000149380
  
Biological name :P4HA3
  
Synonyms : P4HA3 / prolyl 4-hydroxylase subunit alpha 3 / Q7Z4N8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q13.4
Gene start: 74235801
Gene end: 74311657
  
Corresponding Affymetrix probe sets: 1560715_at (Human Genome U133 Plus 2.0 Array)   228703_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000431227
Ensembl peptide - ENSP00000433860
Ensembl peptide - ENSP00000431350
Ensembl peptide - ENSP00000332170
Ensembl peptide - ENSP00000401749
NCBI entrez gene - 283208     See in Manteia.
OMIM - 608987
RefSeq - NM_001288748
RefSeq - NM_182904
RefSeq Peptide - NP_001275677
RefSeq Peptide - NP_878907
swissprot - Q7Z4N8
swissprot - H0YCC3
swissprot - E9PM97
Ensembl - ENSG00000149380
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 p4ha3ENSDARG00000103692Danio rerio
 si:cabz01069582.1ENSDARG00000105349Danio rerio
 P4HA3ENSGALG00000042030Gallus gallus
 P4ha3ENSMUSG00000051048Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P4HA2 / O15460 / prolyl 4-hydroxylase subunit alpha 2ENSG0000007268228
P4HA1 / P13674 / prolyl 4-hydroxylase subunit alpha 1ENSG0000012288428


Protein motifs (from Interpro)
Interpro ID Name
 IPR005123  Oxoglutarate/iron-dependent dioxygenase
 IPR006620  Prolyl 4-hydroxylase, alpha subunit
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013547  Prolyl 4-hydroxylase alpha-subunit, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0019511 peptidyl-proline hydroxylation IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 molecular_functionGO:0004656 procollagen-proline 4-dioxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0031418 L-ascorbic acid binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Collagen biosynthesis and modifying enzymes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000072682 P4HA2 / O15460 / prolyl 4-hydroxylase subunit alpha 2  / complex
 ENSG00000122884 P4HA1 / P13674 / prolyl 4-hydroxylase subunit alpha 1  / complex
 ENSG00000185624 P4HB / P07237 / prolyl 4-hydroxylase subunit beta  / reaction / complex
 ENSG00000123500 Q03692 / COL10A1 / collagen type X alpha 1 chain  / reaction
 ENSG00000149380 P4HA3 / Q7Z4N8 / prolyl 4-hydroxylase subunit alpha 3  / complex
 ENSG00000168542 COL3A1 / P02461 / collagen type III alpha 1 chain  / reaction
 ENSG00000108821 COL1A1 / P02452 / collagen type I alpha 1 chain  / reaction
 ENSG00000164692 COL1A2 / P08123 / collagen type I alpha 2 chain  / reaction






 

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