ENSMUSG00000039462


Mus musculus

Features
Gene ID: ENSMUSG00000039462
  
Biological name :Col10a1
  
Synonyms : Col10a1 / Collagen alpha-1(X) chain / Q05306
  
Possible biological names infered from orthology : collagen type X alpha 1 chain / Q03692
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B1
Gene start: 34389981
Gene end: 34397085
  
Corresponding Affymetrix probe sets: 10362495 (MoGene1.0st)   1422253_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101150
NCBI entrez gene - 12813     See in Manteia.
MGI - MGI:88445
RefSeq - NM_009925
RefSeq Peptide - NP_034055
swissprot - Q05306
Ensembl - ENSMUSG00000039462
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 col10a1aENSDARG00000054753Danio rerio
 col10a1bENSDARG00000101535Danio rerio
 COL10A1ENSGALG00000014965Gallus gallus
 Q03692ENSG00000123500Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Col8a2 / P25318 / Collagen alpha-2(VIII) chain / P25067* / collagen type VIII alpha 2 chain*ENSMUSG0000005617451
Col8a1 / Q00780 / Collagen alpha-1(VIII) chain Vastatin / P27658* / collagen type VIII alpha 1 chain*ENSMUSG0000006819651
Otol1 / Q4ZJM7 / Otolin-1 / A6NHN0*ENSMUSG0000002778824
Q4ZJN1 / C1qtnf9 / Complement C1q and tumor necrosis factor-related protein 9 / B2RNN3* / P0C862* / C1QTNF9B* / C1q and TNF related 9* / C1q and TNF related 9B*ENSMUSG0000007134720
Q9D8U4 / C1qtnf2 / Complement C1q tumor necrosis factor-related protein 2 / Q9BXJ5* / C1q and TNF related 2*ENSMUSG0000004649117
Q8BVD7 / C1qtnf7 / Complement C1q tumor necrosis factor-related protein 7 / Q9BXJ2* / C1q and TNF related 7*ENSMUSG0000006153516
Adipoq / Q60994 / Adiponectin / Q15848* / adiponectin, C1Q and collagen domain containing*ENSMUSG0000002287815
Q8K479 / C1qtnf5 / Complement C1q tumor necrosis factor-related protein 5 / Q9BXJ0* / C1q and TNF related 5*ENSMUSG0000007959214
C1qb / P14106 / Complement C1q subcomponent subunit B / P02746* / complement C1q B chain*ENSMUSG0000003690513
C1qc / Q02105 / Complement C1q subcomponent subunit C / P02747* / complement C1q C chain*ENSMUSG0000003689613


Protein motifs (from Interpro)
Interpro ID Name
 IPR001073  C1q domain
 IPR008160  Collagen triple helix repeat
 IPR008983  Tumour necrosis factor-like domain superfamily
 IPR016133  Insect cysteine-rich antifreeze protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001958 endochondral ossification IEA
 biological_processGO:0051216 cartilage development IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0043235 receptor complex ISO
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Collagen biosynthesis and modifying enzymes
Assembly of collagen fibrils and other multimeric structures
Non-integrin membrane-ECM interactions
Collagen chain trimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000116 abnormal tooth development "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col10a1tm1Bhr/Col10a1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxa2tm1Dnl/Foxa2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Col10a1tm1Bhr/Col10a1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Col10a1tm1Bhr/Col10a1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000162 lordosis "anteriorly convex curvature of the spine, "saddle back" " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62022]
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Allelic Composition: Col10a1tm1Bhr/Col10a1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxa2tm1Dnl/Foxa2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxa2tm1Dnl/Foxa2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Anxa5tm1Epo/Anxa5tm1Epo,Anxa6tm1Moss/Anxa6tm1Moss,Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Col10a1tm1Bhr/Col10a1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col10a1tm1Bhr/Col10a1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Col10a1tm1Bhr/Col10a1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Col10a1tm1Bhr/Col10a1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Col10a1tm1Bhr/Col10a1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Col10a1tm1Bhr/Col10a1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Col10a1tm1Bhr/Col10a1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Col10a1tm1Bhr/Col10a1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col10a1tm1Bhr/Col10a1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col10a1tm1Bhr/Col10a1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002427 dwarfism "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm5(tetO-RNAi:T)Bgh/Gt(ROSA)26Sor+
Genetic Background: chimera involves: C57BL/6 or (129S6/SvEvTac x C57BL/6NCr)F1

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Foxa2tm1Dnl/Foxa2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Col10a1tm1Bhr/Col10a1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ilktm9.1Ref/Ilktm9.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Col10a1tm1.1Rpbh/Col10a1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003408 increased width of hypertrophic chondrocyte zone "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Col10a1tm1.1Rpbh/Col10a1tm1.1Rpbh
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Col10a1tm1.1Rpbh/Col10a1+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Anxa5tm1Epo/Anxa5tm1Epo,Anxa6tm1Moss/Anxa6tm1Moss,Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
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Allelic Composition: Col10a1tm1Bhr/Col10a1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004509 abnormal pelvic girdle bone morphology "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col10a1tm1.1Rpbh/Col10a1tm1.1Rpbh
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004608 abnormal cervical axis morphology "any structural anomaly of the second cervical vertebra (C2) which forms the pivot upon which the first cervical (atlas, C1) vertebra rotates" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col10a1tm1Bhr/Col10a1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col10a1tm1Bhr/Col10a1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col10a1tm1Bhr/Col10a1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col10a1tm1.1Rpbh/Col10a1tm1.1Rpbh
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Anxa5tm1Epo/Anxa5tm1Epo,Anxa6tm1Moss/Anxa6tm1Moss,Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col10a1tm1Bhr/Col10a1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Col10a1tm1Bhr/Col10a1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Col10a1tm1Bhr/Col10a1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col10a1tm1Bhr/Col10a1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col10a1tm1Bhr/Col10a1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008024 absent lymph nodes "absence of the oval or bean shaped bodies located along the lymphatic system that consist of densely packed lymphocytes, lymph fluid and connective tissue; these are the sites where acquired immune responses are launched" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col10a1tm1Bhr/Col10a1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col10a1tm1Bhr/Col10a1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col10a1tm1Bhr/Col10a1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008092 abnormal T-helper 2 cell differentiation "atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Anxa5tm1Epo/Anxa5tm1Epo,Anxa6tm1Moss/Anxa6tm1Moss,Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0008272 abnormal endochondral bone ossification "anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]
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Allelic Composition: Gt(ROSA)26Sortm5(tetO-RNAi:T)Bgh/Gt(ROSA)26Sor+
Genetic Background: chimera involves: C57BL/6 or (129S6/SvEvTac x C57BL/6NCr)F1

 MP:0008477 decreased spleen red pulp amount "reduction in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col10a1tm1Bhr/Col10a1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col10a1tm1.1Rpbh/Col10a1tm1.1Rpbh
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008682 decreased interleukin-17 secretion "reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0009780 abnormal chondrocyte physiology "any functional anomaly of nondividing cartilage cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gt(ROSA)26Sortm5(tetO-RNAi:T)Bgh/Gt(ROSA)26Sor+
Genetic Background: chimera involves: C57BL/6 or (129S6/SvEvTac x C57BL/6NCr)F1

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxa2tm1Dnl/Foxa2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Col10a1tm1Bhr/Col10a1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0013763 increased T-helper cell number "increase in the number of an effector T cell that provides help in the form of secreted cytokines to other immune cells" [CL:0000912]
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Allelic Composition: Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Anxa5tm1Epo/Anxa5tm1Epo,Anxa6tm1Moss/Anxa6tm1Moss,Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0020010 decreased bone mineral density of femur "reduction in the amount of mineral per square centimeter of bone (usually g/cm2) in the long bone of the thigh" [GOC:NV]
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Allelic Composition: Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0020354 increased endoplasmic reticulum stress "increase in in the accumulation of misfolded or unfolded proteins in the endoplasmic reticulum lumen; this accumulation may be stimulated by genetic or enviromental factors" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Col10a1tm1.1Rpbh/Col10a1tm1.1Rpbh
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019916 P4ha1 / Q60715 / Prolyl 4-hydroxylase subunit alpha-1 / P13674*  / reaction
 ENSMUSG00000018906 P4ha2 / Q60716 / Prolyl 4-hydroxylase subunit alpha-2 / O15460*  / reaction
 ENSMUSG00000025130 P4hb / P09103 / prolyl 4-hydroxylase, beta polypeptide / P07237* / prolyl 4-hydroxylase subunit beta*  / reaction / complex
 ENSMUSG00000051048 P4ha3 / prolyl 4-hydroxylase subunit alpha 3 / Q7Z4N8*  / reaction






 

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