ENSMUSG00000079592


Mus musculus

Features
Gene ID: ENSMUSG00000079592
  
Biological name :C1qtnf5
  
Synonyms : C1qtnf5 / Complement C1q tumor necrosis factor-related protein 5 / Q8K479
  
Possible biological names infered from orthology : C1q and TNF related 5 / Q9BXJ0
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A5.1
Gene start: 44107245
Gene end: 44109187
  
Corresponding Affymetrix probe sets: 10584653 (MoGene1.0st)   1424762_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110469
Ensembl peptide - ENSMUSP00000123040
Ensembl peptide - ENSMUSP00000146051
Ensembl peptide - ENSMUSP00000145714
Ensembl peptide - ENSMUSP00000145546
Ensembl peptide - ENSMUSP00000110463
Ensembl peptide - ENSMUSP00000110464
Ensembl peptide - ENSMUSP00000110466
NCBI entrez gene - 235312     See in Manteia.
MGI - MGI:2385958
RefSeq - NM_001040632
RefSeq - NM_001190313
RefSeq - NM_001190319
RefSeq - NM_145613
RefSeq - NM_001040631
RefSeq Peptide - NP_001035721
RefSeq Peptide - NP_001177242
RefSeq Peptide - NP_001177248
RefSeq Peptide - NP_663588
RefSeq Peptide - NP_001035722
swissprot - Q8K479
swissprot - A0A0U1RPN0
swissprot - A0A0U1RNV1
swissprot - A0A0U1RNF8
swissprot - Q4ZJN4
swissprot - D3YUN6
Ensembl - ENSMUSG00000079592
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 c1qtnf5ENSDARG00000056134Danio rerio
 C1QTNF5ENSGALG00000006758Gallus gallus
 Q9BXJ0ENSG00000223953Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q4ZJN1 / C1qtnf9 / Complement C1q and tumor necrosis factor-related protein 9 / B2RNN3* / P0C862* / C1QTNF9B* / C1q and TNF related 9* / C1q and TNF related 9B*ENSMUSG0000007134740
Q05306 / Col10a1 / Collagen alpha-1(X) chain / Q03692* / collagen type X alpha 1 chain*ENSMUSG0000003946240
Col8a2 / P25318 / Collagen alpha-2(VIII) chain / P25067* / collagen type VIII alpha 2 chain*ENSMUSG0000005617438
Col8a1 / Q00780 / Collagen alpha-1(VIII) chain Vastatin / P27658* / collagen type VIII alpha 1 chain*ENSMUSG0000006819637
Otol1 / Q4ZJM7 / Otolin-1 / A6NHN0*ENSMUSG0000002778837
Q8BVD7 / C1qtnf7 / Complement C1q tumor necrosis factor-related protein 7 / Q9BXJ2* / C1q and TNF related 7*ENSMUSG0000006153537
Adipoq / Q60994 / Adiponectin / Q15848* / adiponectin, C1Q and collagen domain containing*ENSMUSG0000002287836
C1qb / P14106 / Complement C1q subcomponent subunit B / P02746* / complement C1q B chain*ENSMUSG0000003690535
C1qc / Q02105 / Complement C1q subcomponent subunit C / P02747* / complement C1q C chain*ENSMUSG0000003689635
Q9D8U4 / C1qtnf2 / Complement C1q tumor necrosis factor-related protein 2 / Q9BXJ5* / C1q and TNF related 2*ENSMUSG0000004649134


Protein motifs (from Interpro)
Interpro ID Name
 IPR001073  C1q domain
 IPR008160  Collagen triple helix repeat
 IPR008983  Tumour necrosis factor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009306 protein secretion IMP
 biological_processGO:0048839 inner ear development IDA
 biological_processGO:0070206 protein trimerization IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005923 bicellular tight junction IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0016328 lateral plasma membrane IDA
 cellular_componentGO:0030133 transport vesicle IDA
 cellular_componentGO:0042995 cell projection IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042802 identical protein binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001004 abnormal photoreceptor morphology "structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxo3mommeR1/Foxo3tm1.1Rdp,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ

 MP:0001006 abnormal cone morphology "structural or developmental anomaly of the retinal receptors that give rise to color vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxo3mommeR1/Foxo3tm1.1Rdp,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Foxo3mommeR1/Foxo3tm1.1Rdp,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Tg(Kap-icre)29066/2Sig/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Tg(Kap-icre)29066/2Sig/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL

 MP:0002864 abnormal ocular fundus morphology "malformation of the posterior concave interior of the eye, consisting of the retina, the choroid, the posterior segment of the sclera, the optic disk, and blood vessels, visible by an ophthalmoscope" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Foxo3mommeR1/Foxo3tm1.1Rdp,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Tg(Kap-icre)29066/2Sig/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL

 MP:0002984 retina hypoplasia "less than normal number of cells in the thin layer of neural tissue lining the back of the eyeball which contains visual receptors" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80994]
Show

Allelic Composition: Foxo3mommeR1/Foxo3tm1.1Rdp,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Tg(Kap-icre)29066/2Sig/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxo3mommeR1/Foxo3tm1.1Rdp,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
Show

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Tg(Kap-icre)29066/2Sig/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL

 MP:0003730 abnormal photoreceptor inner segments "malformation/anomalous structure of the photoreceptor layer which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxo3mommeR1/Foxo3tm1.1Rdp,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxo3mommeR1/Foxo3tm1.1Rdp,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxo3mommeR1/Foxo3tm1.1Rdp,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

Allelic Composition: C1qtnf5tm1.1(KOMP)Vlcg/C1qtnf5tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-C1qtnf5tm1.1(KOMP)Vlcg/Ucd

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Foxo3mommeR1/Foxo3tm1.1Rdp,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ

 MP:0005239 abnormal Bruch membrane morphology "anomalous structure of the transparent, nearly structureless inner layer of the choroid in contact with the pigmented layer of the retina" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxo3mommeR1/Foxo3tm1.1Rdp,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Tg(Kap-icre)29066/2Sig/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Foxo3mommeR1/Foxo3tm1.1Rdp,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ

 MP:0008444 retinal cone cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxo3mommeR1/Foxo3tm1.1Rdp,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ

 MP:0008446 decreased retinal cone cell number "reduced number of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxo3mommeR1/Foxo3tm1.1Rdp,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ

 MP:0008448 abnormal retinal cone cell inner segment morphology "any structural anomaly of the retinal cone cell region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxo3mommeR1/Foxo3tm1.1Rdp,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ

 MP:0008455 abnormal retinal rod cell inner segment morphology "any structural anomaly of the retinal rod cell region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxo3mommeR1/Foxo3tm1.1Rdp,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxo3mommeR1/Foxo3tm1.1Rdp,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ

 MP:0008587 short photoreceptor outer segment "decreased length of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxo3mommeR1/Foxo3tm1.1Rdp,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Tg(Kap-icre)29066/2Sig/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Tg(Kap-icre)29066/2Sig/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0011968 decreased threshold for auditory brainstem response "reduction in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system" [MGI:csmith]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0013278 decreased fasted circulating glucose level "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Tg(Kap-icre)29066/2Sig/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * SJL

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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