ENSMUSG00000068196


Mus musculus

Features
Gene ID: ENSMUSG00000068196
  
Biological name :Col8a1
  
Synonyms : Col8a1 / Collagen alpha-1(VIII) chain Vastatin / Q00780
  
Possible biological names infered from orthology : collagen type VIII alpha 1 chain / P27658
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: C1.1
Gene start: 57624258
Gene end: 57754737
  
Corresponding Affymetrix probe sets: 10440091 (MoGene1.0st)   1418440_at (Mouse Genome 430 2.0 Array)   1418441_at (Mouse Genome 430 2.0 Array)   1455627_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000086745
NCBI entrez gene - 12837     See in Manteia.
MGI - MGI:88463
RefSeq - NM_007739
RefSeq Peptide - NP_031765
swissprot - Q00780
Ensembl - ENSMUSG00000068196
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 col8a1aENSDARG00000077403Danio rerio
 col8a1bENSDARG00000003533Danio rerio
 COL8A1ENSGALG00000015253Gallus gallus
 COL8A1ENSG00000144810Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Col8a2 / P25318 / Collagen alpha-2(VIII) chain / P25067* / collagen type VIII alpha 2 chain*ENSMUSG0000005617451
Q05306 / Col10a1 / Collagen alpha-1(X) chain / Q03692* / collagen type X alpha 1 chain*ENSMUSG0000003946246
Otol1 / Q4ZJM7 / Otolin-1 / A6NHN0*ENSMUSG0000002778823
Q4ZJN1 / C1qtnf9 / Complement C1q and tumor necrosis factor-related protein 9 / B2RNN3* / P0C862* / C1QTNF9B* / C1q and TNF related 9* / C1q and TNF related 9B*ENSMUSG0000007134719
Q8BVD7 / C1qtnf7 / Complement C1q tumor necrosis factor-related protein 7 / Q9BXJ2* / C1q and TNF related 7*ENSMUSG0000006153515
Adipoq / Q60994 / Adiponectin / Q15848* / adiponectin, C1Q and collagen domain containing*ENSMUSG0000002287813
Q9D8U4 / C1qtnf2 / Complement C1q tumor necrosis factor-related protein 2 / Q9BXJ5* / C1q and TNF related 2*ENSMUSG0000004649113
Q8K479 / C1qtnf5 / Complement C1q tumor necrosis factor-related protein 5 / Q9BXJ0* / C1q and TNF related 5*ENSMUSG0000007959212
C1qc / Q02105 / Complement C1q subcomponent subunit C / P02747* / complement C1q C chain*ENSMUSG0000003689612
C1qb / P14106 / Complement C1q subcomponent subunit B / P02746* / complement C1q B chain*ENSMUSG0000003690512


Protein motifs (from Interpro)
Interpro ID Name
 IPR001073  C1q domain
 IPR008160  Collagen triple helix repeat
 IPR008983  Tumour necrosis factor-like domain superfamily
 IPR016133  Insect cysteine-rich antifreeze protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IDA
 biological_processGO:0035987 endodermal cell differentiation IEA
 biological_processGO:0048593 camera-type eye morphogenesis IGI
 biological_processGO:0050673 epithelial cell proliferation IGI
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Collagen biosynthesis and modifying enzymes
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
Collagen chain trimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003092 reduced corneal stroma thickness "reduced width of the lamellated connective tissue layer of the cornea" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:81616]
Show

Allelic Composition: Lmnatm3Stw/Lmnatm3Stw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL

Allelic Composition: Col8a1tm1Bjro/Col8a1tm1Bjro,Col8a2tm1Bjro/Col8a2tm1Bjro
Genetic Background: B6.129S4-Col8a2tm1Bjro Col8a1tm1Bjro

 MP:0004284 abnormal Descemet membrane "any structural abnormality in the transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea, considered to be a highly developed basement membrane" [MESH:A09.371.060.217.271, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm3Stw/Lmnatm3Stw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL

Allelic Composition: Col8a1tm1Bjro/Col8a1tm1Bjro,Col8a2tm1Bjro/Col8a2tm1Bjro
Genetic Background: B6.129S4-Col8a2tm1Bjro Col8a1tm1Bjro

 MP:0005193 abnormal anterior eye segment morphology "anomalous structure of any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmnatm3Stw/Lmnatm3Stw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL

 MP:0005205 abnormal eye anterior chamber "anomaly of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lmnatm3Stw/Lmnatm3Stw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL

Allelic Composition: Col8a1tm1Bjro/Col8a1tm1Bjro,Col8a2tm1Bjro/Col8a2tm1Bjro
Genetic Background: B6.129S4-Col8a2tm1Bjro Col8a1tm1Bjro

 MP:0005301 abnormal corneal endothelium morphology "anomalous structure of the single layer of large flattened cells that cover the surface of the cornea" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Col8a1tm1Bjro/Col8a1tm1Bjro,Col8a2tm1Bjro/Col8a2tm1Bjro
Genetic Background: B6.129S4-Col8a2tm1Bjro Col8a1tm1Bjro

 MP:0005543 corneal thinning "decreased thickness of the cornea, the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col8a1tm1Bjro/Col8a1tm1Bjro,Col8a2tm1Bjro/Col8a2tm1Bjro
Genetic Background: B6.129S4-Col8a2tm1Bjro Col8a1tm1Bjro

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr