ENSMUSG00000022878


Mus musculus

Features
Gene ID: ENSMUSG00000022878
  
Biological name :Adipoq
  
Synonyms : Adiponectin / Adipoq / Q60994
  
Possible biological names infered from orthology : adiponectin, C1Q and collagen domain containing / Q15848
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B1
Gene start: 23146536
Gene end: 23158028
  
Corresponding Affymetrix probe sets: 10434747 (MoGene1.0st)   1422651_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126793
Ensembl peptide - ENSMUSP00000023593
NCBI entrez gene - 11450     See in Manteia.
MGI - MGI:106675
RefSeq - NM_009605
RefSeq Peptide - NP_033735
swissprot - E9PWU4
swissprot - Q60994
Ensembl - ENSMUSG00000022878
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adipoqaENSDARG00000062228Danio rerio
 adipoqbENSDARG00000100086Danio rerio
 ADIPOQENSGALG00000005554Gallus gallus
 ADIPOQENSG00000181092Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q4ZJN1 / C1qtnf9 / Complement C1q and tumor necrosis factor-related protein 9 / B2RNN3* / P0C862* / C1QTNF9B* / C1q and TNF related 9* / C1q and TNF related 9B*ENSMUSG0000007134743
Q05306 / Col10a1 / Collagen alpha-1(X) chain / Q03692* / collagen type X alpha 1 chain*ENSMUSG0000003946241
Otol1 / Q4ZJM7 / Otolin-1 / A6NHN0*ENSMUSG0000002778840
Col8a1 / Q00780 / Collagen alpha-1(VIII) chain Vastatin / P27658* / collagen type VIII alpha 1 chain*ENSMUSG0000006819640
Q8BVD7 / C1qtnf7 / Complement C1q tumor necrosis factor-related protein 7 / Q9BXJ2* / C1q and TNF related 7*ENSMUSG0000006153539
Col8a2 / P25318 / Collagen alpha-2(VIII) chain / P25067* / collagen type VIII alpha 2 chain*ENSMUSG0000005617437
Q9D8U4 / C1qtnf2 / Complement C1q tumor necrosis factor-related protein 2 / Q9BXJ5* / C1q and TNF related 2*ENSMUSG0000004649137
C1qc / Q02105 / Complement C1q subcomponent subunit C / P02747* / complement C1q C chain*ENSMUSG0000003689636
Q8K479 / C1qtnf5 / Complement C1q tumor necrosis factor-related protein 5 / Q9BXJ0* / C1q and TNF related 5*ENSMUSG0000007959236
C1qb / P14106 / Complement C1q subcomponent subunit B / P02746* / complement C1q B chain*ENSMUSG0000003690534


Protein motifs (from Interpro)
Interpro ID Name
 IPR001073  C1q domain
 IPR008160  Collagen triple helix repeat
 IPR008983  Tumour necrosis factor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006006 glucose metabolic process IMP
 biological_processGO:0006635 fatty acid beta-oxidation IMP
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0009744 response to sucrose IEA
 biological_processGO:0009749 response to glucose IMP
 biological_processGO:0009967 positive regulation of signal transduction IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0010739 positive regulation of protein kinase A signaling IEA
 biological_processGO:0010745 negative regulation of macrophage derived foam cell differentiation IEA
 biological_processGO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0010875 positive regulation of cholesterol efflux IEA
 biological_processGO:0010906 regulation of glucose metabolic process IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0019395 fatty acid oxidation IDA
 biological_processGO:0030336 negative regulation of cell migration IDA
 biological_processGO:0030853 negative regulation of granulocyte differentiation IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0031953 negative regulation of protein autophosphorylation IEA
 biological_processGO:0032270 positive regulation of cellular protein metabolic process IEA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IEA
 biological_processGO:0032757 positive regulation of interleukin-8 production IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0033034 positive regulation of myeloid cell apoptotic process IEA
 biological_processGO:0033211 adiponectin-activated signaling pathway IEA
 biological_processGO:0034115 negative regulation of heterotypic cell-cell adhesion IEA
 biological_processGO:0034383 low-density lipoprotein particle clearance IEA
 biological_processGO:0034612 response to tumor necrosis factor IEA
 biological_processGO:0035690 cellular response to drug IDA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043407 negative regulation of MAP kinase activity IDA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation IEA
 biological_processGO:0045650 negative regulation of macrophage differentiation IEA
 biological_processGO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process IEA
 biological_processGO:0045721 negative regulation of gluconeogenesis IDA
 biological_processGO:0045776 negative regulation of blood pressure IEA
 biological_processGO:0045777 positive regulation of blood pressure IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045923 positive regulation of fatty acid metabolic process IMP
 biological_processGO:0046326 positive regulation of glucose import IDA
 biological_processGO:0046888 negative regulation of hormone secretion IEA
 biological_processGO:0050728 negative regulation of inflammatory response IDA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050765 negative regulation of phagocytosis IEA
 biological_processGO:0050805 negative regulation of synaptic transmission IEA
 biological_processGO:0050873 brown fat cell differentiation IDA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051899 membrane depolarization IEA
 biological_processGO:0060081 membrane hyperpolarization IEA
 biological_processGO:0070208 protein heterotrimerization IPI
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070543 response to linoleic acid IEA
 biological_processGO:0070994 detection of oxidative stress IMP
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071639 positive regulation of monocyte chemotactic protein-1 production IEA
 biological_processGO:0071872 cellular response to epinephrine stimulus IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0090317 negative regulation of intracellular protein transport IEA
 biological_processGO:1900121 negative regulation of receptor binding IEA
 biological_processGO:1904706 negative regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:1904753 negative regulation of vascular associated smooth muscle cell migration IEA
 biological_processGO:2000279 negative regulation of DNA biosynthetic process IEA
 biological_processGO:2000467 positive regulation of glycogen (starch) synthase activity IEA
 biological_processGO:2000478 positive regulation of metanephric glomerular visceral epithelial cell development IMP
 biological_processGO:2000481 positive regulation of cAMP-dependent protein kinase activity IMP
 biological_processGO:2000534 positive regulation of renal albumin absorption IMP
 biological_processGO:2000584 negative regulation of platelet-derived growth factor receptor-alpha signaling pathway IDA
 biological_processGO:2000590 negative regulation of metanephric mesenchymal cell migration IDA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 cellular_componentGO:0071944 cell periphery ISS
 molecular_functionGO:0005102 signaling receptor binding IDA
 molecular_functionGO:0005179 hormone activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0033691 sialic acid binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
AMPK inhibits chREBP transcriptional activation activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000010 abnormal abdominal fat pads "malformed or aberrant size of the encapsulated adipose tissue in the abdomen" [J:65146]
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Allelic Composition: Foxe3rct/Foxe3rct,mrct/mrct
Genetic Background: SJL/J

 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Foxe3rct/Foxe3rct,mrct/mrct
Genetic Background: SJL/J

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Foxe3rct/Foxe3rct,mrct/mrct
Genetic Background: SJL/J

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ftotm1Urt/Fto+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Adipoqtm1Chan/Adipoq+
Genetic Background: B6.129-Adipoqtm1Chan

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Adipoqtm1Far/Adipoqtm1Far
Genetic Background: involves: C57BL/6J

Allelic Composition: Adipoqtm1Chan/Adipoqtm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Foxe3rct/Foxe3rct,mrct/mrct
Genetic Background: SJL/J

Allelic Composition: Adipoqtm1Far/Adipoqtm1Far,Dgat1tm1Far/Dgat1tm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001272 increased metastatic potential 
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr
Genetic Background: 129S6.129-Chrdtm1Emdr

Allelic Composition: Adipoqtm1Chan/Adipoq+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: FVB.Cg-Adipoqtm1Chan Tg(MMTV-PyVT)634Mul

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adipoqtm1Far/Adipoqtm1Far,Dgat1tm1Far/Dgat1tm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001533 abnormal skeleton physiology "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxe3rct/Foxe3rct,mrct/mrct
Genetic Background: SJL/J

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxe3rct/Foxe3rct,mrct/mrct
Genetic Background: SJL/J

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxe3rct/Foxe3rct,mrct/mrct
Genetic Background: SJL/J

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: KitlSl/Kitl+
Genetic Background: involves: C3H

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Foxe3rct/Foxe3rct,mrct/mrct
Genetic Background: SJL/J

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Foxe3rct/Foxe3rct,mrct/mrct
Genetic Background: SJL/J

 MP:0001613 abnormal vasodilation "anomalous widening of the lumen of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxe3rct/Foxe3rct,mrct/mrct
Genetic Background: SJL/J

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
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Allelic Composition: Adipoqtm1Far/Adipoqtm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Foxe3rct/Foxe3rct,mrct/mrct
Genetic Background: SJL/J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxe3rct/Foxe3rct,mrct/mrct
Genetic Background: SJL/J

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Foxe3rct/Foxe3rct,mrct/mrct
Genetic Background: SJL/J

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adipoqtm1Chan/Adipoqtm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxe3rct/Foxe3rct,mrct/mrct
Genetic Background: SJL/J

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adipoqtm1Far/Adipoqtm1Far,Dgat1tm1Far/Dgat1tm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ftotm1Urt/Fto+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Adipoqtm1Chan/Adipoq+
Genetic Background: B6.129-Adipoqtm1Chan

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Adipoqtm1Far/Adipoqtm1Far
Genetic Background: involves: C57BL/6J

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Foxe3rct/Foxe3rct,mrct/mrct
Genetic Background: SJL/J

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Adipoqtm1Chan/Adipoq+
Genetic Background: B6.129-Adipoqtm1Chan

 MP:0002970 abnormal white fat morphology "structural aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Adipoqtm1Chan/Adipoqtm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Adipoqtm1Pesch/Adipoqtm1Pesch
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr
Genetic Background: 129S6.129-Chrdtm1Emdr

Allelic Composition: Adipoqtm1Chan/Adipoq+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: FVB.Cg-Adipoqtm1Chan Tg(MMTV-PyVT)634Mul

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Adipoqtm1Chan/Adipoqtm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tcf7l1tm1.1(cre/ERT2)Hng/Tcf7l1tm1.1(cre/ERT2)Hng
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr
Genetic Background: 129S6.129-Chrdtm1Emdr

Allelic Composition: Adipoqtm1Chan/Adipoq+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: FVB.Cg-Adipoqtm1Chan Tg(MMTV-PyVT)634Mul

 MP:0003828 pulmonary edema "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003948 abnormal gas homeostasis "anomaly in the state of equilibrium in the body of gaseous elements in animal tissues or blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003953 abnormal hormone level "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003957 abnormal nitric oxide homeostasis "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ftotm1Urt/Fto+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003962 abnormal adrenaline level "aberrant concentration in the blood or tissues of this catacholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003964 abnormal noradrenaline level "aberrant concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004148 increased cortical bone thickness "thicker than normal superficial layer of compact bone" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004149 increased bone strength "increased ability of bone to endure the application of force without yielding or breaking" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: KitlSl/Kitl+
Genetic Background: involves: C3H

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Adipoqtm1Pesch/Adipoqtm1Pesch
Genetic Background: B6.129S7-Adipoqtm1Pesch

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004892 increased adiponectin level "greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipoqtm1Ish/Adipoq+,Bglap/Bglap2tm1Kry/Bglap2+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Adipoqtm1Ish/Adipoq+,Bglap/Bglap2tm1Kry/Bglap+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Adipoqtm1Chan/Adipoqtm1Chan
Genetic Background: B6.129-Adipoqtm1Chan

Allelic Composition: Adipoqtm1Chan/Adipoq+
Genetic Background: B6.129-Adipoqtm1Chan

Allelic Composition: Adipoqtm1Chan/Adipoq+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: B6.Cg-Adipoqtm1Chan Tg(MMTV-PyVT)634Mul

Allelic Composition: Adipoqtm1Chan/Adipoq+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: FVB.Cg-Adipoqtm1Chan Tg(MMTV-PyVT)634Mul

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004988 increased osteoblast cell number "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Dbhtm1Rpa/Dbh+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004989 decreased osteoblast cell number "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Foxe3rct/Foxe3rct,mrct/mrct
Genetic Background: SJL/J

 MP:0005114 premature hair loss "release of fur at an earlier than expected time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adipoqtm1Far/Adipoqtm1Far,Dgat1tm1Far/Dgat1tm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Adipoqtm1Far/Adipoqtm1Far,Dgat1tm1Far/Dgat1tm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Adipoqtm1Pesch/Adipoqtm1Pesch
Genetic Background: B6.129S7-Adipoqtm1Pesch

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005291 abnormal glucose tolerance "deviation from the normal response to oral consumption or intravenous injection of specified amounts of glucose; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adipoqtm1Far/Adipoqtm1Far,Dgat1tm1Far/Dgat1tm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: KitlSl/Kitl+
Genetic Background: involves: C3H

Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Adipoqtm1Pesch/Adipoqtm1Pesch
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Adipoqtm1Pesch/Adipoqtm1Pesch,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Adipoqtm1Far/Adipoqtm1Far
Genetic Background: involves: C57BL/6J

Allelic Composition: Adipoqtm1Far/Adipoqtm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: KitlSl/Kitl+
Genetic Background: involves: C3H

Allelic Composition: Adipoqtm1Tka/Adipoq+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Adipoqtm1Ish/Adipoq+,Bglap/Bglap2tm1Kry/Bglap2+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Adipoqtm1Ish/Adipoq+,Bglap/Bglap2tm1Kry/Bglap+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005336 abnormal inguinal fat pad "malformed or aberrant size of the encapsulated adipose tissue found in the groin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541]
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Allelic Composition: Adipoqtm1Pesch/Adipoqtm1Pesch
Genetic Background: B6.129S7-Adipoqtm1Pesch

 MP:0005413 vascular restenosis "recurrent narrowing or constriction of a blood vessel following surgical or mechanical injury " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005448 abnormal energy balance "aberrant intake or expenditure of calories as compared to the normal state" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adipoqtm1Far/Adipoqtm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adipoqtm1Far/Adipoqtm1Far,Dgat1tm1Far/Dgat1tm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Adipoqtm1Far/Adipoqtm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Adipoqtm1Far/Adipoqtm1Far,Dgat1tm1Far/Dgat1tm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Dbhtm1Rpa/Dbh+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Adrb2tm1Kry/Adrb2tm1Kry,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005630 increased lung weight "greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr
Genetic Background: 129S6.129-Chrdtm1Emdr

Allelic Composition: Adipoqtm1Chan/Adipoq+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: FVB.Cg-Adipoqtm1Chan Tg(MMTV-PyVT)634Mul

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Adipoqtm1Far/Adipoqtm1Far,Dgat1tm1Far/Dgat1tm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008139 fused podocyte foot processes "coalescence of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries " [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Adipoqtm1Chan/Adipoqtm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008907 decreased total fat pad weight "less than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008908 increased total fat pad weight "greater than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008963 increased carbon dioxide production "increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008964 decreased carbon dioxide production "reduction in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipoqtm1Far/Adipoqtm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adipoqtm1Far/Adipoqtm1Far,Dgat1tm1Far/Dgat1tm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0010018 lung vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adipoqtm1Far/Adipoqtm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adipoqtm1Far/Adipoqtm1Far,Dgat1tm1Far/Dgat1tm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010026 decreased liver cholesterol level "less than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipoqtm1Far/Adipoqtm1Far,Dgat1tm1Far/Dgat1tm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipoqtm1Chan/Adipoq+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: B6.Cg-Adipoqtm1Chan Tg(MMTV-PyVT)634Mul

Allelic Composition: Adipoqtm1Chan/Adipoq+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: FVB.Cg-Adipoqtm1Chan Tg(MMTV-PyVT)634Mul

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
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Allelic Composition: Adipoqtm1Pesch/Adipoqtm1Pesch
Genetic Background: B6.129S7-Adipoqtm1Pesch

 MP:0011016 increased core body temperature "increased degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipoqtm1Pesch/Adipoqtm1Pesch
Genetic Background: B6.129S7-Adipoqtm1Pesch

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr
Genetic Background: 129S6.129-Chrdtm1Emdr

 MP:0011922 abnormal circulating osteocalcin level "aberrant concentration in the blood of this hormone secreted by osteoblasts which are found in bone and dentin" [MPD:Molly]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Adipoqtm1Far/Adipoqtm1Far,Dgat1tm1Far/Dgat1tm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0014174 decreased fatty acid beta-oxidation "decreased rate or incidence of the process that results in the complete oxidation of a long-chain fatty acid, beginning with the addition of coenzyme A to a fatty acid, with successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)" [GO:0006635]
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Allelic Composition: Adipoqtm1Chan/Adipoqtm1Chan
Genetic Background: B6.129-Adipoqtm1Chan

 MP:0020039 increased bone ossification "increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Dbhtm1Rpa/Dbh+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0020040 decreased bone ossification "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0020318 increased vascular endothelial cell adhesion "greater than expected ability of an endothelial cell in the vasculature to adhere to another cell or to a non-cellular component of the environment" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Adipoqtm1Chan/Adipoqtm1Chan
Genetic Background: B6.129-Adipoqtm1Chan

Allelic Composition: Adipoqtm1Chan/Adipoq+
Genetic Background: B6.129-Adipoqtm1Chan

 MP:0020523 decreased susceptibility to induced hypothermia "smaller than expected drop in body temperature in response to treatment (cold-exposure, dietary restriction, ethanol treatment, etc..) designed to induce hypothermia" [MGI:mperry, PMID:24531262]
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Allelic Composition: Adipoqtm1Pesch/Adipoqtm1Pesch
Genetic Background: B6.129S7-Adipoqtm1Pesch

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030168 Q8BQS5 / Adipor2 / adiponectin receptor 2 / Q86V24*  / reaction / complex
 ENSMUSG00000026457 Q91VH1 / Adipor1 / adiponectin receptor 1 / Q96A54*  / complex / reaction
 ENSMUSG00000022878 Adipoq / Q60994 / Adiponectin / Q15848* / adiponectin, C1Q and collagen domain containing*  / complex






 

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