ENSMUSG00000030168


Mus musculus

Features
Gene ID: ENSMUSG00000030168
  
Biological name :Adipor2
  
Synonyms : adiponectin receptor 2 / Adipor2 / Q8BQS5
  
Possible biological names infered from orthology : Q86V24
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F1
Gene start: 119353150
Gene end: 119417704
  
Corresponding Affymetrix probe sets: 10547386 (MoGene1.0st)   1434329_s_at (Mouse Genome 430 2.0 Array)   1437864_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139895
Ensembl peptide - ENSMUSP00000032272
Ensembl peptide - ENSMUSP00000126138
Ensembl peptide - ENSMUSP00000139703
NCBI entrez gene - 68465     See in Manteia.
MGI - MGI:93830
RefSeq - XM_011241448
RefSeq - NM_001355692
RefSeq - NM_197985
RefSeq - XM_006506538
RefSeq Peptide - NP_001342621
RefSeq Peptide - NP_932102
swissprot - Q53YY3
swissprot - A0A087WPS4
swissprot - Q8BQS5
swissprot - A0A087WPB1
Ensembl - ENSMUSG00000030168
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adipor2ENSDARG00000101849Danio rerio
 ADIPOR2ENSGALG00000035533Gallus gallus
 Q86V24ENSG00000006831Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q91VH1 / Adipor1 / adiponectin receptor 1 / Q96A54*ENSMUSG0000002645767
Paqr3 / Q6TCG8 / progestin and adipoQ receptor family member III / Q6TCH7* / progestin and adipoQ receptor family member 3*ENSMUSG0000005572522
Paqr4 / Q9JJE4 / Progestin and adipoQ receptor family member 4 / Q8N4S7*ENSMUSG0000002390919


Protein motifs (from Interpro)
Interpro ID Name
 IPR004254  AdipoR/Haemolysin-III-related


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0009755 hormone-mediated signaling pathway ISS
 biological_processGO:0019395 fatty acid oxidation ISS
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0033211 adiponectin-activated signaling pathway IMP
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0046326 positive regulation of glucose import IEA
 biological_processGO:0061042 vascular wound healing IMP
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane ISO
 molecular_functionGO:0042802 identical protein binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0055100 adiponectin binding ISO
 molecular_functionGO:0097003 adipokinetic hormone receptor activity ISO


Pathways (from Reactome)
Pathway description
AMPK inhibits chREBP transcriptional activation activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000010 abnormal abdominal fat pads "malformed or aberrant size of the encapsulated adipose tissue in the abdomen" [J:65146]
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Allelic Composition: Adipor1tm1Dgen/Adipor1tm1Dgen
Genetic Background: B6.129P2-Adipor1tm1Dgen/Mmnc

 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adipor2tm2Dgen/Adipor2tm2Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adipor1tm1Dgen/Adipor1tm1Dgen
Genetic Background: B6.129P2-Adipor1tm1Dgen/Mmnc

Allelic Composition: Adipor2tm2Dgen/Adipor2tm2Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adipor1tm1Tka/Adipor1tm1Tka,Adipor2tm1Tka/Adipor2tm1Tka
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Adipor1tm1Dgen/Adipor1tm1Dgen
Genetic Background: B6.129P2-Adipor1tm1Dgen/Mmnc

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: A830005F24Riktm1.1(KOMP)Mbp/A830005F24Rik+
Genetic Background: C57BL/6N-A830005F24Riktm1.1(KOMP)Mbp/Ucd

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Adipor1tm1Tka/Adipor1tm1Tka,Adipor2tm1Tka/Adipor2tm1Tka
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Adipor2tm1Tka/Adipor2tm1Tka
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Surf1tm2.1Zev/Surf1tm2.1Zev
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

Allelic Composition: Adipor2tm1Tka/Adipor2tm1Tka
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Adipor2tm2Dgen/Adipor2tm2Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Adipor2tm1Tka/Adipor2tm1Tka
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adipor1tm1Dgen/Adipor1tm1Dgen
Genetic Background: B6.129P2-Adipor1tm1Dgen/Mmnc

 MP:0002176 high brain weight "greater than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adipor1tm1Dgen/Adipor1tm1Dgen
Genetic Background: B6.129P2-Adipor1tm1Dgen/Mmnc

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Adipor2tm2Dgen/Adipor2tm2Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Adipor1tm1Dgen/Adipor1tm1Dgen
Genetic Background: B6.129P2-Adipor1tm1Dgen/Mmnc

Allelic Composition: Adipor2tm2Dgen/Adipor2tm2Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adipor2tm2Dgen/Adipor2tm2Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Adipor1tm1Tka/Adipor1tm1Tka,Adipor2tm1Tka/Adipor2tm1Tka
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003953 abnormal hormone level "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adipor1tm1Dgen/Adipor1tm1Dgen
Genetic Background: B6.129P2-Adipor1tm1Dgen/Mmnc

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Adipor1tm1Dgen/Adipor1tm1Dgen
Genetic Background: B6.129P2-Adipor1tm1Dgen/Mmnc

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

Allelic Composition: Adipor2tm1Dgen/Adipor2tm1Dgen
Genetic Background: B6.129P2-Adipor2tm1Dgen

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipor2tm1Dgen/Adipor2tm1Dgen
Genetic Background: B6.129P2-Adipor2tm1Dgen

 MP:0004892 increased adiponectin level "greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipor2tm1Dgen/Adipor2tm1Dgen
Genetic Background: B6.129P2-Adipor2tm1Dgen

Allelic Composition: Adipor2tm2Dgen/Adipor2tm2Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004929 decreased epididymis weight "reduction in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

 MP:0005146 decreased circulating VLDL cholesterol level "less than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adipor2tm2Dgen/Adipor2tm2Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adipor1tm1Dgen/Adipor1tm1Dgen
Genetic Background: B6.129P2-Adipor1tm1Dgen/Mmnc

Allelic Composition: Adipor2tm2Dgen/Adipor2tm2Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adipor1tm1Dgen/Adipor1tm1Dgen
Genetic Background: B6.129P2-Adipor1tm1Dgen/Mmnc

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adipor1tm1Tka/Adipor1tm1Tka,Adipor2tm1Tka/Adipor2tm1Tka
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Adipor2tm1Tka/Adipor2tm1Tka
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Adipor1tm1Tka/Adipor1tm1Tka,Adipor2tm1Tka/Adipor2tm1Tka
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Adipor2tm1Tka/Adipor2tm1Tka
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adipor1tm1Dgen/Adipor1tm1Dgen
Genetic Background: B6.129P2-Adipor1tm1Dgen/Mmnc

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Adipor2tm2Dgen/Adipor2tm2Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adipor1tm1Tka/Adipor1tm1Tka,Adipor2tm1Tka/Adipor2tm1Tka
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Adipor1tm1Dgen/Adipor1tm1Dgen
Genetic Background: B6.129P2-Adipor1tm1Dgen/Mmnc

Allelic Composition: Adipor2tm2Dgen/Adipor2tm2Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009116 abnormal brown fat cell morphology "any structural anomaly of cells from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals; brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation; brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria" [CL:0000449, GO:0050873, MESH:A.10.165.114.322]
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Allelic Composition: Adipor2tm1Dgen/Adipor2tm1Dgen
Genetic Background: B6.129P2-Adipor2tm1Dgen

 MP:0009269 decreased fat cell size "reduction in the size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Adipor2tm1Dgen/Adipor2tm1Dgen
Genetic Background: B6.129P2-Adipor2tm1Dgen

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipor2tm1Dgen/Adipor2tm1Dgen
Genetic Background: B6.129P2-Adipor2tm1Dgen

 MP:0009303 decreased renal fat pad weight 
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Allelic Composition: Adipor2tm1Dgen/Adipor2tm1Dgen
Genetic Background: B6.129P2-Adipor2tm1Dgen

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipor1tm1Tka/Adipor1tm1Tka,Adipor2tm1Tka/Adipor2tm1Tka
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipor2tm1Dgen/Adipor2tm1Dgen
Genetic Background: B6.129P2-Adipor2tm1Dgen

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: A830005F24Riktm1.1(KOMP)Mbp/A830005F24Rik+
Genetic Background: C57BL/6N-A830005F24Riktm1.1(KOMP)Mbp/Ucd

 MP:0011019 abnormal adaptive thermogenesis "anomaly in the regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [PMID:16836744]
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Allelic Composition: Adipoqtm1Pesch/Adipoqtm1Pesch
Genetic Background: B6.129S7-Adipoqtm1Pesch

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Adipoqtm1Pesch/Adipoqtm1Pesch
Genetic Background: B6.129S7-Adipoqtm1Pesch

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Adipor2tm1Dgen/Adipor2tm1Dgen
Genetic Background: B6.129P2-Adipor2tm1Dgen

 MP:0014169 decreased brown adipose tissue mass "decreased physical bulk or volume of brown adipose tissue" [MGI:csmith]
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Allelic Composition: Adipor2tm1Dgen/Adipor2tm1Dgen
Genetic Background: B6.129P2-Adipor2tm1Dgen

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
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Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026457 Q91VH1 / Adipor1 / adiponectin receptor 1 / Q96A54*  / complex
 ENSMUSG00000022878 Adipoq / Q60994 / Adiponectin / Q15848* / adiponectin, C1Q and collagen domain containing*  / reaction / complex
 ENSMUSG00000030168 Q8BQS5 / Adipor2 / adiponectin receptor 2 / Q86V24*  / complex






 

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