ENSMUSG00000026457


Mus musculus

Features
Gene ID: ENSMUSG00000026457
  
Biological name :Adipor1
  
Synonyms : adiponectin receptor 1 / Adipor1 / Q91VH1
  
Possible biological names infered from orthology : Q96A54
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: E4
Gene start: 134415378
Gene end: 134433351
  
Corresponding Affymetrix probe sets: 10350015 (MoGene1.0st)   1424312_at (Mouse Genome 430 2.0 Array)   1439017_x_at (Mouse Genome 430 2.0 Array)   1451311_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027727
Ensembl peptide - ENSMUSP00000107856
NCBI entrez gene - 72674     See in Manteia.
MGI - MGI:1919924
RefSeq - NM_028320
RefSeq - NM_001306069
RefSeq Peptide - NP_001292998
RefSeq Peptide - NP_082596
swissprot - Q53YY4
swissprot - Q91VH1
Ensembl - ENSMUSG00000026457
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adipor1aENSDARG00000002912Danio rerio
 adipor1bENSDARG00000042717Danio rerio
 ADIPOR1ENSGALG00000000094Gallus gallus
 Q96A54ENSG00000159346Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BQS5 / Adipor2 / adiponectin receptor 2 / Q86V24*ENSMUSG0000003016869
Paqr3 / Q6TCG8 / progestin and adipoQ receptor family member III / Q6TCH7* / progestin and adipoQ receptor family member 3*ENSMUSG0000005572526
Paqr4 / Q9JJE4 / Progestin and adipoQ receptor family member 4 / Q8N4S7*ENSMUSG0000002390921


Protein motifs (from Interpro)
Interpro ID Name
 IPR004254  AdipoR/Haemolysin-III-related


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0009755 hormone-mediated signaling pathway ISS
 biological_processGO:0010633 negative regulation of epithelial cell migration IEA
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010906 regulation of glucose metabolic process IMP
 biological_processGO:0019216 regulation of lipid metabolic process IMP
 biological_processGO:0019395 fatty acid oxidation IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0033210 leptin-mediated signaling pathway IEA
 biological_processGO:0033211 adiponectin-activated signaling pathway IMP
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IEA
 biological_processGO:0046427 positive regulation of JAK-STAT cascade IEA
 biological_processGO:0046628 positive regulation of insulin receptor signaling pathway IEA
 biological_processGO:1901223 negative regulation of NIK/NF-kappaB signaling IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0055100 adiponectin binding ISO
 molecular_functionGO:0097003 adipokinetic hormone receptor activity ISO


Pathways (from Reactome)
Pathway description
AMPK inhibits chREBP transcriptional activation activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
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Allelic Composition: Pax3Sp-3J/Pax3+
Genetic Background: involves: C57BL/6J

 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax3Sp-3J/Pax3+
Genetic Background: involves: C57BL/6J

 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adipor1tm1Tka/Adipor1tm1Tka,Adipor2tm1Tka/Adipor2tm1Tka
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Adgrv1tm1.1(KOMP)Vlcg/Adgrv1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Adgrv1tm1.1(KOMP)Vlcg/Ucd

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adgrv1tm1.1(KOMP)Vlcg/Adgrv1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Adgrv1tm1.1(KOMP)Vlcg/Ucd

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Pax3Sp-3J/Pax3+
Genetic Background: involves: C57BL/6J

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Adgrv1tm1.1(KOMP)Vlcg/Adgrv1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Adgrv1tm1.1(KOMP)Vlcg/Ucd

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Surf1tm2.1Zev/Surf1tm2.1Zev
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

Allelic Composition: Adipor1tm1Tka/Adipor1tm1Tka,Adipor2tm1Tka/Adipor2tm1Tka
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001566 hyperphosphatemia "abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Adgrv1tm1.1(KOMP)Vlcg/Adgrv1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Adgrv1tm1.1(KOMP)Vlcg/Ucd

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Surf1tm2.1Zev/Surf1tm2.1Zev
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

Allelic Composition: Adipor1tm1Tka/Adipor1tm1Tka,Adipor2tm1Tka/Adipor2tm1Tka
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Adipor1tm2Tka/Adipor1tm2Tka,Tg(Ckmm-cre)5Khn/0
Genetic Background: B6.Cg-Adipor1tm2Tka Tg(Ckmm-cre)5Khn

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Surf1tm2.1Zev/Surf1tm2.1Zev
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

Allelic Composition: Adipor1tm2Tka/Adipor1tm2Tka,Tg(Ckmm-cre)5Khn/0
Genetic Background: B6.Cg-Adipor1tm2Tka Tg(Ckmm-cre)5Khn

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax3Sp-3J/Pax3+
Genetic Background: involves: C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

 MP:0003020 decreased circulating chloride level "reduced concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Adipor1tm1Tka/Adipor1tm1Tka,Adipor2tm1Tka/Adipor2tm1Tka
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adipor1tm2Tka/Adipor1tm2Tka,Tg(Ckmm-cre)5Khn/0
Genetic Background: B6.Cg-Adipor1tm2Tka Tg(Ckmm-cre)5Khn

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipor1tm1Dgen/Adipor1tm1Dgen
Genetic Background: B6.129P2-Adipor1tm1Dgen/Mmnc

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipoqtm1Pesch/Adipoqtm1Pesch
Genetic Background: B6.129S7-Adipoqtm1Pesch

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pax3Sp-3J/Pax3+
Genetic Background: involves: C57BL/6J

Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adipor1tm2Tka/Adipor1tm2Tka,Tg(Ckmm-cre)5Khn/0
Genetic Background: B6.Cg-Adipor1tm2Tka Tg(Ckmm-cre)5Khn

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Surf1tm2.1Zev/Surf1tm2.1Zev
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

Allelic Composition: Adipor1tm1Tka/Adipor1tm1Tka,Adipor2tm1Tka/Adipor2tm1Tka
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Adipor1tm1Dgen/Adipor1tm1Dgen
Genetic Background: B6.129P2-Adipor1tm1Dgen/Mmnc

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adipor1tm2Tka/Adipor1tm2Tka,Tg(Ckmm-cre)5Khn/0
Genetic Background: B6.Cg-Adipor1tm2Tka Tg(Ckmm-cre)5Khn

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Surf1tm2.1Zev/Surf1tm2.1Zev
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

Allelic Composition: Adipor1tm1Tka/Adipor1tm1Tka,Adipor2tm1Tka/Adipor2tm1Tka
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Adipor1tm2Tka/Adipor1tm2Tka,Tg(Ckmm-cre)5Khn/0
Genetic Background: B6.Cg-Adipor1tm2Tka Tg(Ckmm-cre)5Khn

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
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Allelic Composition: Adipor1tm1Dgen/Adipor1tm1Dgen
Genetic Background: B6.129P2-Adipor1tm1Dgen/Mmnc

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adipor1tm1Dgen/Adipor1tm1Dgen
Genetic Background: B6.129P2-Adipor1tm1Dgen/Mmnc

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Surf1tm2.1Zev/Surf1tm2.1Zev
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

Allelic Composition: Adipor1tm2Tka/Adipor1tm2Tka,Tg(Ckmm-cre)5Khn/0
Genetic Background: B6.Cg-Adipor1tm2Tka Tg(Ckmm-cre)5Khn

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Surf1tm2.1Zev/Surf1tm2.1Zev
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

Allelic Composition: Adipor1tm1Tka/Adipor1tm1Tka,Adipor2tm1Tka/Adipor2tm1Tka
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Adipor1tm1Dgen/Adipor1tm1Dgen
Genetic Background: B6.129P2-Adipor1tm1Dgen/Mmnc

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Adipor1tm2Tka/Adipor1tm2Tka,Tg(Ckmm-cre)5Khn/0
Genetic Background: B6.Cg-Adipor1tm2Tka Tg(Ckmm-cre)5Khn

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipor1tm1Tka/Adipor1tm1Tka,Adipor2tm1Tka/Adipor2tm1Tka
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Adipor1tm1Dgen/Adipor1tm1Dgen
Genetic Background: B6.129P2-Adipor1tm1Dgen/Mmnc

 MP:0009409 abnormal skeletal muscle fiber type ratio "deviation from the standard ratios of fiber types in a given skeletal muscle compared to control samples" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipor1tm2Tka/Adipor1tm2Tka,Tg(Ckmm-cre)5Khn/0
Genetic Background: B6.Cg-Adipor1tm2Tka Tg(Ckmm-cre)5Khn

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0011019 abnormal adaptive thermogenesis "anomaly in the regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [PMID:16836744]
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Allelic Composition: Adipoqtm1Pesch/Adipoqtm1Pesch
Genetic Background: B6.129S7-Adipoqtm1Pesch

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Adipoqtm1Pesch/Adipoqtm1Pesch
Genetic Background: B6.129S7-Adipoqtm1Pesch

 MP:0012106 impaired exercise endurance "impaired performance during controlled physical activity" [MGI:smb]
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Allelic Composition: Adipor1tm2Tka/Adipor1tm2Tka,Tg(Ckmm-cre)5Khn/0
Genetic Background: B6.Cg-Adipor1tm2Tka Tg(Ckmm-cre)5Khn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030168 Q8BQS5 / Adipor2 / adiponectin receptor 2 / Q86V24*  / complex
 ENSMUSG00000026457 Q91VH1 / Adipor1 / adiponectin receptor 1 / Q96A54*  / complex
 ENSMUSG00000022878 Adipoq / Q60994 / Adiponectin / Q15848* / adiponectin, C1Q and collagen domain containing*  / complex / reaction






 

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