ENSMUSG00000056174


Mus musculus

Features
Gene ID: ENSMUSG00000056174
  
Biological name :Col8a2
  
Synonyms : Col8a2 / Collagen alpha-2(VIII) chain / P25318
  
Possible biological names infered from orthology : collagen type VIII alpha 2 chain / P25067
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.2
Gene start: 126286793
Gene end: 126314330
  
Corresponding Affymetrix probe sets: 10508142 (MoGene1.0st)   1434667_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123003
Ensembl peptide - ENSMUSP00000070270
NCBI entrez gene - 329941     See in Manteia.
MGI - MGI:88464
RefSeq - NM_199473
RefSeq - XM_017320266
RefSeq Peptide - NP_955767
swissprot - A3KFY1
swissprot - P25318
Ensembl - ENSMUSG00000056174
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 col8a2ENSDARG00000060893Danio rerio
 COL8A2ENSGALG00000002298Gallus gallus
 COL8A2ENSG00000171812Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Col8a1 / Q00780 / Collagen alpha-1(VIII) chain Vastatin / P27658* / collagen type VIII alpha 1 chain*ENSMUSG0000006819655
Q05306 / Col10a1 / Collagen alpha-1(X) chain / Q03692* / collagen type X alpha 1 chain*ENSMUSG0000003946250
Otol1 / Q4ZJM7 / Otolin-1 / A6NHN0*ENSMUSG0000002778822
Q4ZJN1 / C1qtnf9 / Complement C1q and tumor necrosis factor-related protein 9 / B2RNN3* / P0C862* / C1QTNF9B* / C1q and TNF related 9* / C1q and TNF related 9B*ENSMUSG0000007134720
Q8BVD7 / C1qtnf7 / Complement C1q tumor necrosis factor-related protein 7 / Q9BXJ2* / C1q and TNF related 7*ENSMUSG0000006153514
Q9D8U4 / C1qtnf2 / Complement C1q tumor necrosis factor-related protein 2 / Q9BXJ5* / C1q and TNF related 2*ENSMUSG0000004649114
C1qc / Q02105 / Complement C1q subcomponent subunit C / P02747* / complement C1q C chain*ENSMUSG0000003689613
C1qb / P14106 / Complement C1q subcomponent subunit B / P02746* / complement C1q B chain*ENSMUSG0000003690513
Q8K479 / C1qtnf5 / Complement C1q tumor necrosis factor-related protein 5 / Q9BXJ0* / C1q and TNF related 5*ENSMUSG0000007959213
Adipoq / Q60994 / Adiponectin / Q15848* / adiponectin, C1Q and collagen domain containing*ENSMUSG0000002287813


Protein motifs (from Interpro)
Interpro ID Name
 IPR001073  C1q domain
 IPR008160  Collagen triple helix repeat
 IPR008983  Tumour necrosis factor-like domain superfamily
 IPR016133  Insect cysteine-rich antifreeze protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0048593 camera-type eye morphogenesis IGI
 biological_processGO:0050673 epithelial cell proliferation IGI
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Collagen biosynthesis and modifying enzymes
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
Collagen chain trimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm2Mok/Trp53tm2Mok
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Col8a2Aca23/Col8a2Aca23
Genetic Background: C57BL/6J-Col8a2Aca23

 MP:0003092 reduced corneal stroma thickness "reduced width of the lamellated connective tissue layer of the cornea" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:81616]
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Allelic Composition: Col8a1tm1Bjro/Col8a1tm1Bjro,Col8a2tm1Bjro/Col8a2tm1Bjro
Genetic Background: B6.129S4-Col8a2tm1Bjro Col8a1tm1Bjro

Allelic Composition: Col8a2Aca23/Col8a2+
Genetic Background: C57BL/6J-Col8a2Aca23

Allelic Composition: Col8a2Aca23/Col8a2Aca23
Genetic Background: C57BL/6J-Col8a2Aca23

 MP:0004284 abnormal Descemet membrane "any structural abnormality in the transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea, considered to be a highly developed basement membrane" [MESH:A09.371.060.217.271, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm3Stw/Lmnatm3Stw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL

Allelic Composition: Col8a1tm1Bjro/Col8a1tm1Bjro,Col8a2tm1Bjro/Col8a2tm1Bjro
Genetic Background: B6.129S4-Col8a2tm1Bjro Col8a1tm1Bjro

Allelic Composition: Col8a2Aca23/Col8a2+
Genetic Background: C57BL/6J-Col8a2Aca23

Allelic Composition: Col8a2Aca23/Col8a2Aca23
Genetic Background: C57BL/6J-Col8a2Aca23

Allelic Composition: Col8a2tm1.1Asj/Col8a2tm1.1Asj
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Col8a2tm2.1Asj/Col8a2tm2.1Asj
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0005193 abnormal anterior eye segment morphology "anomalous structure of any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmnatm3Stw/Lmnatm3Stw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL

 MP:0005205 abnormal eye anterior chamber "anomaly of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Col8a1tm1Bjro/Col8a1tm1Bjro,Col8a2tm1Bjro/Col8a2tm1Bjro
Genetic Background: B6.129S4-Col8a2tm1Bjro Col8a1tm1Bjro

Allelic Composition: Col8a2Aca23/Col8a2+
Genetic Background: C57BL/6J-Col8a2Aca23

Allelic Composition: Col8a2Aca23/Col8a2Aca23
Genetic Background: C57BL/6J-Col8a2Aca23

 MP:0005301 abnormal corneal endothelium morphology "anomalous structure of the single layer of large flattened cells that cover the surface of the cornea" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col8a1tm1Bjro/Col8a1tm1Bjro,Col8a2tm1Bjro/Col8a2tm1Bjro
Genetic Background: B6.129S4-Col8a2tm1Bjro Col8a1tm1Bjro

Allelic Composition: Col8a2tm1.1Asj/Col8a2tm1.1Asj
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Col8a2tm2.1Asj/Col8a2tm2.1Asj
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0005543 corneal thinning "decreased thickness of the cornea, the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col8a1tm1Bjro/Col8a1tm1Bjro,Col8a2tm1Bjro/Col8a2tm1Bjro
Genetic Background: B6.129S4-Col8a2tm1Bjro Col8a1tm1Bjro

Allelic Composition: Col8a2Aca23/Col8a2+
Genetic Background: C57BL/6J-Col8a2Aca23

Allelic Composition: Col8a2Aca23/Col8a2Aca23
Genetic Background: C57BL/6J-Col8a2Aca23

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Col8a2Aca23/Col8a2+
Genetic Background: C57BL/6J-Col8a2Aca23

Allelic Composition: Col8a2Aca23/Col8a2Aca23
Genetic Background: C57BL/6J-Col8a2Aca23

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Col8a2tm1.1Asj/Col8a2tm1.1Asj
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Col8a2tm1.1Asj/Col8a2tm1.1Asj
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
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Allelic Composition: Col8a2tm2.1Asj/Col8a2tm2.1Asj
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Col8a2tm1.1Asj/Col8a2tm1.1Asj
Genetic Background: involves: 129S6/SvEvTac

 MP:0009378 abnormal endoplasmic reticulum morphology "any structural anomaly of irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells" [GO:0005783]
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Allelic Composition: Col8a2tm1.1Asj/Col8a2tm1.1Asj
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Col8a2tm2.1Asj/Col8a2tm2.1Asj
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0009829 enlarged eye anterior chamber "increased size of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MESH:A09.371.060.067, MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Col8a2Aca23/Col8a2+
Genetic Background: C57BL/6J-Col8a2Aca23

Allelic Composition: Col8a2Aca23/Col8a2Aca23
Genetic Background: C57BL/6J-Col8a2Aca23

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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