ENSG00000181092


Homo sapiens

Features
Gene ID: ENSG00000181092
  
Biological name :ADIPOQ
  
Synonyms : adiponectin, C1Q and collagen domain containing / ADIPOQ / Q15848
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q27.3
Gene start: 186842690
Gene end: 186858463
  
Corresponding Affymetrix probe sets: 207175_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000389814
Ensembl peptide - ENSP00000320709
NCBI entrez gene - 9370     See in Manteia.
OMIM - 605441
RefSeq - NM_001177800
RefSeq - NM_004797
RefSeq Peptide - NP_001171271
RefSeq Peptide - NP_004788
swissprot - Q15848
swissprot - A8K660
Ensembl - ENSG00000181092
  
Related genetic diseases (OMIM): 612556 - Adiponectin deficiency, 612556
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adipoqaENSDARG00000062228Danio rerio
 adipoqbENSDARG00000100086Danio rerio
 ADIPOQENSGALG00000005554Gallus gallus
 AdipoqENSMUSG00000022878Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P0C862 / C1QTNF9 / C1q and TNF related 9ENSG0000024065445
B2RNN3 / C1QTNF9B / C1q and TNF related 9BENSG0000020586344
OTOL1 / A6NHN0 / otolin 1ENSG0000018244743
Q03692 / COL10A1 / collagen type X alpha 1 chainENSG0000012350041
COL8A1 / P27658 / collagen type VIII alpha 1 chainENSG0000014481040
Q9BXJ2 / C1QTNF7 / C1q and TNF related 7ENSG0000016314539
Q9BXJ5 / C1QTNF2 / C1q and TNF related 2ENSG0000014586139
COL8A2 / P25067 / collagen type VIII alpha 2 chainENSG0000017181238
C1QC / P02747 / complement C1q C chainENSG0000015918937
Q9BXJ0 / C1QTNF5 / C1q and TNF related 5ENSG0000022395336
C1QB / P02746 / complement C1q B chainENSG0000017336934


Protein motifs (from Interpro)
Interpro ID Name
 IPR001073  C1q domain
 IPR008160  Collagen triple helix repeat
 IPR008983  Tumour necrosis factor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006091 generation of precursor metabolites and energy TAS
 biological_processGO:0006635 fatty acid beta-oxidation ISS
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0009744 response to sucrose IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0009967 positive regulation of signal transduction ISS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway IDA
 biological_processGO:0010739 positive regulation of protein kinase A signaling IDA
 biological_processGO:0010745 negative regulation of macrophage derived foam cell differentiation IDA
 biological_processGO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IDA
 biological_processGO:0010875 positive regulation of cholesterol efflux IDA
 biological_processGO:0010906 regulation of glucose metabolic process IDA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0019395 fatty acid oxidation ISS
 biological_processGO:0030336 negative regulation of cell migration ISS
 biological_processGO:0030853 negative regulation of granulocyte differentiation IDA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0031953 negative regulation of protein autophosphorylation IDA
 biological_processGO:0032270 positive regulation of cellular protein metabolic process IDA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IDA
 biological_processGO:0032757 positive regulation of interleukin-8 production IDA
 biological_processGO:0032869 cellular response to insulin stimulus ISS
 biological_processGO:0033034 positive regulation of myeloid cell apoptotic process IDA
 biological_processGO:0033211 adiponectin-activated signaling pathway IEA
 biological_processGO:0034115 negative regulation of heterotypic cell-cell adhesion IDA
 biological_processGO:0034383 low-density lipoprotein particle clearance IDA
 biological_processGO:0034612 response to tumor necrosis factor IDA
 biological_processGO:0035690 cellular response to drug ISS
 biological_processGO:0042304 regulation of fatty acid biosynthetic process TAS
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042593 glucose homeostasis ISS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0043407 negative regulation of MAP kinase activity ISS
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation IEA
 biological_processGO:0045650 negative regulation of macrophage differentiation IDA
 biological_processGO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process IDA
 biological_processGO:0045721 negative regulation of gluconeogenesis ISS
 biological_processGO:0045776 negative regulation of blood pressure IDA
 biological_processGO:0045777 positive regulation of blood pressure IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045923 positive regulation of fatty acid metabolic process ISS
 biological_processGO:0046326 positive regulation of glucose import IEA
 biological_processGO:0046888 negative regulation of hormone secretion IEA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050765 negative regulation of phagocytosis IDA
 biological_processGO:0050805 negative regulation of synaptic transmission IDA
 biological_processGO:0050873 brown fat cell differentiation ISS
 biological_processGO:0051260 protein homooligomerization ISS
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051899 membrane depolarization IEA
 biological_processGO:0060081 membrane hyperpolarization IEA
 biological_processGO:0070208 protein heterotrimerization IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0070543 response to linoleic acid IEA
 biological_processGO:0070994 detection of oxidative stress ISS
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071639 positive regulation of monocyte chemotactic protein-1 production IDA
 biological_processGO:0071872 cellular response to epinephrine stimulus IEA
 biological_processGO:0072659 protein localization to plasma membrane IDA
 biological_processGO:0090317 negative regulation of intracellular protein transport IDA
 biological_processGO:1900121 negative regulation of receptor binding IDA
 biological_processGO:1904706 negative regulation of vascular smooth muscle cell proliferation IDA
 biological_processGO:1904753 negative regulation of vascular associated smooth muscle cell migration IDA
 biological_processGO:2000279 negative regulation of DNA biosynthetic process IDA
 biological_processGO:2000467 positive regulation of glycogen (starch) synthase activity ISS
 biological_processGO:2000478 positive regulation of metanephric glomerular visceral epithelial cell development ISS
 biological_processGO:2000481 positive regulation of cAMP-dependent protein kinase activity IDA
 biological_processGO:2000534 positive regulation of renal albumin absorption IDA
 biological_processGO:2000584 negative regulation of platelet-derived growth factor receptor-alpha signaling pathway ISS
 biological_processGO:2000590 negative regulation of metanephric mesenchymal cell migration ISS
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005102 signaling receptor binding ISS
 molecular_functionGO:0005125 cytokine activity NAS
 molecular_functionGO:0005179 hormone activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0033691 sialic acid binding IDA
 molecular_functionGO:0042802 identical protein binding TAS
 molecular_functionGO:0042803 protein homodimerization activity IPI


Pathways (from Reactome)
Pathway description
AMPK inhibits chREBP transcriptional activation activity
Transcriptional regulation of white adipocyte differentiation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000159346 Q96A54 / ADIPOR1 / adiponectin receptor 1  / complex / reaction
 ENSG00000006831 Q86V24 / ADIPOR2 / adiponectin receptor 2  / complex / reaction
 ENSG00000181092 ADIPOQ / Q15848 / adiponectin, C1Q and collagen domain containing  / complex






 

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