ENSG00000144810


Homo sapiens

Features
Gene ID: ENSG00000144810
  
Biological name :COL8A1
  
Synonyms : COL8A1 / collagen type VIII alpha 1 chain / P27658
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q12.1
Gene start: 99638475
Gene end: 99799226
  
Corresponding Affymetrix probe sets: 214587_at (Human Genome U133 Plus 2.0 Array)   221152_at (Human Genome U133 Plus 2.0 Array)   226237_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000273342
Ensembl peptide - ENSP00000482679
Ensembl peptide - ENSP00000387589
Ensembl peptide - ENSP00000261037
NCBI entrez gene - 1295     See in Manteia.
OMIM - 120251
RefSeq - NM_020351
RefSeq - NM_001850
RefSeq Peptide - NP_001841
RefSeq Peptide - NP_065084
swissprot - P27658
swissprot - C9JTN9
swissprot - A0A087WZI0
Ensembl - ENSG00000144810
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 col8a1aENSDARG00000077403Danio rerio
 col8a1bENSDARG00000003533Danio rerio
 COL8A1ENSGALG00000015253Gallus gallus
 Col8a1ENSMUSG00000068196Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
COL8A2 / P25067 / collagen type VIII alpha 2 chainENSG0000017181251
Q03692 / COL10A1 / collagen type X alpha 1 chainENSG0000012350048
OTOL1 / A6NHN0 / otolin 1ENSG0000018244723
P0C862 / C1QTNF9 / C1q and TNF related 9ENSG0000024065418
B2RNN3 / C1QTNF9B / C1q and TNF related 9BENSG0000020586318
Q9BXJ2 / C1QTNF7 / C1q and TNF related 7ENSG0000016314514
C1QB / P02746 / complement C1q B chainENSG0000017336913
ADIPOQ / Q15848 / adiponectin, C1Q and collagen domain containingENSG0000018109213
Q9BXJ5 / C1QTNF2 / C1q and TNF related 2ENSG0000014586113
Q9BXJ0 / C1QTNF5 / C1q and TNF related 5ENSG0000022395312
C1QC / P02747 / complement C1q C chainENSG0000015918912


Protein motifs (from Interpro)
Interpro ID Name
 IPR001073  C1q domain
 IPR008160  Collagen triple helix repeat
 IPR008983  Tumour necrosis factor-like domain superfamily
 IPR016133  Insect cysteine-rich antifreeze protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IEA
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0030574 collagen catabolic process TAS
 biological_processGO:0035987 endodermal cell differentiation IEP
 biological_processGO:0048593 camera-type eye morphogenesis IEA
 biological_processGO:0050673 epithelial cell proliferation IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005591 collagen type VIII trimer TAS
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Collagen degradation
Collagen biosynthesis and modifying enzymes
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
Collagen chain trimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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