ENSMUSG00000001506


Mus musculus

Features
Gene ID: ENSMUSG00000001506
  
Biological name :Col1a1
  
Synonyms : Col1a1 / Collagen alpha-1(I) chain / P11087
  
Possible biological names infered from orthology : collagen type I alpha 1 chain / P02452
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 94936224
Gene end: 94953042
  
Corresponding Affymetrix probe sets: 10380419 (MoGene1.0st)   1423669_at (Mouse Genome 430 2.0 Array)   1455494_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001547
NCBI entrez gene - 12842     See in Manteia.
MGI - MGI:88467
RefSeq - NM_007742
RefSeq Peptide - NP_031768
swissprot - P11087
Ensembl - ENSMUSG00000001506
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 col1a1aENSDARG00000012405Danio rerio
 col1a1bENSDARG00000035809Danio rerio
 COL1A1ENSG00000108821Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Col2a1 / P28481 / Collagen alpha-1(II) chain Collagen alpha-1(II) chain Chondrocalcin / P02458* / collagen type II alpha 1 chain*ENSMUSG0000002248371
Col3a1 / P08121 / Collagen alpha-1(III) chain / P02461* / collagen type III alpha 1 chain*ENSMUSG0000002604361
Col5a2 / Q3U962 / Collagen alpha-2(V) chain / P05997* / collagen type V alpha 2 chain*ENSMUSG0000002604260
Col1a2 / Q01149 / Collagen alpha-2(I) chain / P08123* / collagen type I alpha 2 chain*ENSMUSG0000002966160
Col5a1 / O88207 / Collagen alpha-1(V) chain / P20908* / collagen type V alpha 1 chain*ENSMUSG0000002683745
Q61245 / Col11a1 / Collagen alpha-1(XI) chain / P12107* / collagen type XI alpha 1 chain*ENSMUSG0000002796644
Col5a3 / collagen, type V, alpha 3 / P25940* / collagen type V alpha 3 chain*ENSMUSG0000000409843
Q64739 / Col11a2 / Collagen alpha-2(XI) chain / P13942* / collagen type XI alpha 2 chain*ENSMUSG0000002433042
Q5QNQ9 / Col27a1 / Collagen alpha-1(XXVII) chain / Q8IZC6* / collagen type XXVII alpha 1 chain*ENSMUSG0000004567238
Q30D77 / Col24a1 / Collagen alpha-1(XXIV) chain / Q17RW2* / collagen type XXIV alpha 1 chain*ENSMUSG0000002819737


Protein motifs (from Interpro)
Interpro ID Name
 IPR000885  Fibrillar collagen, C-terminal
 IPR001007  VWFC domain
 IPR008160  Collagen triple helix repeat
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR016133  Insect cysteine-rich antifreeze protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IEA
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001568 blood vessel development IEA
 biological_processGO:0001649 osteoblast differentiation IEP
 biological_processGO:0001957 intramembranous ossification IGI
 biological_processGO:0001958 endochondral ossification IMP
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010812 negative regulation of cell-substrate adhesion IDA
 biological_processGO:0015031 protein transport IMP
 biological_processGO:0030199 collagen fibril organization IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0031960 response to corticosteroid IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032964 collagen biosynthetic process IEA
 biological_processGO:0034504 protein localization to nucleus IEA
 biological_processGO:0034505 tooth mineralization IEA
 biological_processGO:0038063 collagen-activated tyrosine kinase receptor signaling pathway IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0043588 skin development IMP
 biological_processGO:0043589 skin morphogenesis IEA
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IEA
 biological_processGO:0044691 tooth eruption IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0048705 skeletal system morphogenesis IGI
 biological_processGO:0048706 embryonic skeletal system development IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0055093 response to hyperoxia IEA
 biological_processGO:0060325 face morphogenesis IGI
 biological_processGO:0060346 bone trabecula formation IGI
 biological_processGO:0060351 cartilage development involved in endochondral bone morphogenesis IMP
 biological_processGO:0070208 protein heterotrimerization IDA
 biological_processGO:0071230 cellular response to amino acid stimulus IDA
 biological_processGO:0071260 cellular response to mechanical stimulus IEP
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0071306 cellular response to vitamin E IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1902617 response to fluoride IEA
 biological_processGO:1902618 cellular response to fluoride IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005584 collagen type I trimer IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0005201 extracellular matrix structural constituent IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048407 platelet-derived growth factor binding IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Collagen degradation
Extracellular matrix organization
Collagen biosynthesis and modifying enzymes
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Assembly of collagen fibrils and other multimeric structures
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Anchoring fibril formation
Crosslinking of collagen fibrils
Non-integrin membrane-ECM interactions
ECM proteoglycans
GP1b-IX-V activation signalling
Platelet Adhesion to exposed collagen
Platelet Aggregation (Plug Formation)
MET activates PTK2 signaling
Collagen chain trimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dnah11b2b1727Clo/Dnah11b2b1727Clo
Genetic Background: C57BL/6J-Dnah11b2b1727Clo

 MP:0000013 abnormal fat distribution "alterations in the normal placement and amount of body fat" [J:57315]
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Allelic Composition: Scn5atm1Care/Scn5a+
Genetic Background: FVB.129P2-Scn5atm1Care

 MP:0000017 big ears "outer ears of a greater than normal size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0000061 fragile skeleton "easily damaged or broken bones" [J:14208]
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Allelic Composition: Flt4tm1Ali/Flt4tm1Ali
Genetic Background: Not Specified

Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0000064 failure of secondary bone resorption "inability of osteoclasts to degrade the organic and inorganic phases of bone by absorption" [J:67040, J:61295]
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Allelic Composition: Nfe2l2tm1Ney/Nfe2l2tm1Ney,Nfe2l3tm1Vbl/Nfe2l3tm1Vbl
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0000067 osteopetrosis "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Nfe2l2tm1Ney/Nfe2l2tm1Ney,Nfe2l3tm1Vbl/Nfe2l3tm1Vbl
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0000069 kyphoscoliosis "kyphosis combined with scoliosis" [MGI:CML, J:66943]
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Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Nfe2l2tm1Ney/Nfe2l2tm1Ney,Nfe2l3tm1Vbl/Nfe2l3tm1Vbl
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Col1a1tm1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0000141 abnormal vertebral body morphology "malformed main portion of the vertebra anterior to the vertebral canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0000161 scoliosis "lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0000172 abnormal bone marrow cell number "Increased or decreased number of cells that make up the core cavities of bones when compared to the norm" [MGI:tc]
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Allelic Composition: Col1a1tm1(tetO-GFP/RNAi:Rad21)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm2(tetO-LIN28B)Gqda/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0000216 absent erythrocyte precursors "lack of progenitors of the erythrocyte lineage" [J:23061]
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Allelic Composition: Col1a1tm1(tetO-cre)Haho/?,Gfi1btm1.1Haho/Gfi1btm1.1Haho
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col1a1tm1(CAG-Mir22)Ppp/Col1a1tm1(CAG-Mir22)Ppp,Tg(Mx1-cre)1Cgn/0
Genetic Background: Not Specified

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1tm2(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000229 abnormal megakaryocyte differentiation "atypical process of formation and development these very large bone marrow cells which release mature platelets" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col1a1tm1(tetO-cre)Haho/?,Gfi1btm1.1Haho/Gfi1btm1.1Haho
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col1a1tm2(tetO-IDH2*R140Q)Ppp/Col1a1tm2(tetO-IDH2*R140Q)Ppp,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-GFP/RNAi:Rad21)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm1(CAG-Mir22)Ppp/Col1a1tm1(CAG-Mir22)Ppp,Tg(Mx1-cre)1Cgn/0
Genetic Background: Not Specified

 MP:0000248 macrocytosis "condition in which erythrocytes are larger than normal in size" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1tm2(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000255 vasculature congestion "obstruction of the normal flux of blood within the blood vessel network" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm3(CAG-IDH2*R140Q)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Col1a1tm3(CAG-IDH2*R140Q)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
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Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: C3HeB/FeJ-Col1a1Aga2

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Col1a1tm3(CAG-IDH2*R140Q)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000350 abnormal cell proliferation "anomalous growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dll3pu/Dll3pu
Genetic Background: involves: 101/Rl * C3H/He * C3H/Rl * C57BL/6

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-SOX2)Mjm/Col1a1+,Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J

Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Terttm3Rdp/Terttm3Rdp
Genetic Background: involves: C57BL/6

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm4(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000378 absent hair follicles "missing epidermal invaginations from which the hair shaft develops" [J:65039]
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Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Lepob/Lepob,Plin4tm1Vlcg/Plin4tm1Vlcg
Genetic Background: involves: C57BL/6J

 MP:0000412 excessive hair 
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Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm4(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Lepob/Lepob,Plin4tm1Vlcg/Plin4tm1Vlcg
Genetic Background: involves: C57BL/6J

Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0000418 patchy hair "uneven spots of hair growth on the body" [J:26975]
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Allelic Composition: Ptx3tm1Mant/Ptx3tm1Mant
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
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Allelic Composition: Lepob/Lepob,Plin4tm1Vlcg/Plin4tm1Vlcg
Genetic Background: involves: C57BL/6J

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: involves: 129X1/SvJ

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm4(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000455 abnormal maxilla morphology "malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

 MP:0000462 abnormal digestive system morphology "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Gfap-cre)77.6Mvs/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6NHsd

 MP:0000471 abnormal stomach epithelium morphology "malformation of the epithelial layer of the stomach " [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000473 abnormal stomach glandular epithelium morphology "malformation of the gland-containing epithelial layer of the stomach" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:54637]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-Ctnnb1*)Hoch/Col1a1tm2(tetO-Ctnnb1*)Hoch,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000489 abnormal large intestine morphology "structural or developmental anomalies of the intestinum crassum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rgntm1Aish/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Col1a1tm2(tetO-Ctnnb1*)Hoch/Col1a1tm2(tetO-Ctnnb1*)Hoch,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Col1a1tm2(tetO-LIN28B)Gqda/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Six2-EGFP/cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CD-1

 MP:0000528 delayed kidney development "late onset of the induction and/or differentiation of the kidney" [J:18048]
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Allelic Composition: Apptm2.1Tcs/Apptm2.1Tcs,Casttm1Tcs/Casttm1Tcs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
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Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(hs1473-PITX1)Smun/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dmdmdx-4Cv/Dmdmdx-4Cv,Terctm1Rdp/Terctm1Rdp
Genetic Background: B6.Cg-Terctm1Rdp Dmdmdx-4Cv

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Dmdmdx-4Cv/Dmdmdx-4Cv,Terctm1Rdp/Terctm1Rdp
Genetic Background: B6.Cg-Terctm1Rdp Dmdmdx-4Cv

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rad18tm1a(EUCOMM)Wtsi/Rad18tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0000589 thin tail "a tail with a smaller diameter than the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Itga8tm1.1Rdav/Itga8tm1.1Rdav,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA

Allelic Composition: Col1a1tm3(tetO-Fosl1,-DsRed)Wag/Col1a1+,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

Allelic Composition: Col1a1tm5(tetO-Jun/Fos)Wag/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Tg(Cebpb-tTA)#Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Tg(Cebpb-tTA)#Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(CAG-Mir22)Ppp/Col1a1tm1(CAG-Mir22)Ppp,Tg(Mx1-cre)1Cgn/0
Genetic Background: Not Specified

Allelic Composition: Col1a1tm3(tetO-Fosl1,-DsRed)Wag/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-IDH2*R140Q)Ppp/Col1a1tm2(tetO-IDH2*R140Q)Ppp,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm3(CAG-IDH2*R140Q)Kkw/Col1a1+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ahrtm1Gonz/Ahrtm1Gonz
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm3(CAG-IDH2*R140Q)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0000764 abnormal tongue epithelium morphology "malformation of the epithelial layer of the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptx3tm1Mant/Ptx3tm1Mant
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
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Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

 MP:0001200 thick skin "greater depth of skin " [J:47225]
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0001211 wrinkled skin "irregular folds and/or indentations on the skin" [J:19212]
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Rag1tm1Mom/Rag1tm1Mom,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0001214 skin hyperplasia "increased cell number in the skin; usually results in thick skin" [J:47225]
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Rag1tm1Mom/Rag1tm1Mom,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Col1a1tm1(tetO-CDKN2A)Ibp/Col1a1+,Tg(KRT5-rtTA)#Glk/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0001243 abnormal dermal layer morphology "malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Flt4tm1Ali/Flt4tm1Ali
Genetic Background: Not Specified

Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0001245 thick dermal layer "increased depth of the dermis" [J:65033]
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Allelic Composition: Ptx3tm1Mant/Ptx3tm1Mant
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Col1a1tm3(tetO-Mirlet7g/Mir21)Gqda/Col1a1+,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Nfe2l2tm1Ney/Nfe2l2tm1Ney,Nfe2l3tm1Vbl/Nfe2l3tm1Vbl
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: C3HeB/FeJ-Col1a1Aga2

Allelic Composition: Col1a1tm1(tetO-CTNNB1)Tcd/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

Allelic Composition: Col1a1tm2(tetO-Fosl2,-DsRed)Wag/Col1a1+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1+,Tg(CMV-rtTA)4Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

Allelic Composition: Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Tg(CMV-rtTA)4Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

Allelic Composition: Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm10(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Tg(CMV-rtTA)4Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

Allelic Composition: Col1a1tm10(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm11(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm11(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Tg(CMV-rtTA)4Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-EML4/ALK)Kkw/Col1a1+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Col1a1tm3(tetO-Fosl1,-DsRed)Wag/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm4(CAG-FGFR2_iIIIb*K660N)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0001264 increased body size "larger than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Pten+,Tg(Gfap-cre)77.6Mvs/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6NHsd

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Mapk13tm1Cnd/Mapk13tm1Cnd
Genetic Background: Not Specified

Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm4(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm3(tetO-Mirlet7g/Mir21)Gqda/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Col1a1tm3(tetO-Mirlet7g/Mir21)Gqda/Col1a1+,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Col1a1tm3(CAG-IDH2*R140Q)Kkw/Col1a1+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0001391 abnormal tail movements "a change from the normal manner of moving the tail" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rad18tm1a(EUCOMM)Wtsi/Rad18tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Ahrtm1Gonz/Ahrtm1Gonz
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Nfe2l2tm1Ney/Nfe2l2tm1Ney,Nfe2l3tm1Vbl/Nfe2l3tm1Vbl
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Terttm3Rdp/Terttm3Rdp
Genetic Background: involves: C57BL/6

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Col1a1tm3(tetO-Fosl1,-DsRed)Wag/Col1a1+,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

 MP:0001570 abnormal circulating enzyme level "aberrent concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Ccr7tm1Rfor/Ccr7tm1Rfor,Tg(DO11.10)10Dlo/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

Allelic Composition: Col1a1tm1(CAG-Mir22)Ppp/Col1a1tm1(CAG-Mir22)Ppp,Tg(Mx1-cre)1Cgn/0
Genetic Background: Not Specified

Allelic Composition: Col1a1tm1(tetO-cre)Haho/?,Gfi1btm1.1Haho/Gfi1btm1.1Haho
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: C3HeB/FeJ-Col1a1Aga2

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm3(CAG-IDH2*R140Q)Kkw/Col1a1+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Ightm1.1Fwa/Ightm1.1Fwa,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm4(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm3(tetO-Mirlet7g/Mir21)Gqda/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1tm2(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Col1a1tm3(tetO-Fosl1,-DsRed)Wag/Col1a1+,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: C3HeB/FeJ-Col1a1Aga2

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+,Tg(CAG-ANGPT1*)5Yo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Col1a1tm3(CAG-IDH2*R140Q)Kkw/Col1a1+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kcnq4tm1.2Tjj/Kcnq4+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001934 increased litter size "greater numbers of live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptx3tm1Mant/Ptx3tm1Mant
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0001938 delayed sexual maturation "immaturity of the sexual organs at a given age" [J:61190]
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Col1a1tm1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

Allelic Composition: Col1a1tm5(tetO-GFP/RNAi:Cdkn2a)Slowe/Col1a1+,Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sortm1(rtTA*M2)Jae,Krastm4Tyj/Kras+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Col1a1tm3(CAG-IDH2*R140Q)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Col1a1tm4(CAG-FGFR2_iIIIb*K660N)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0002014 papilloma "benign epithelial tumor" [J:47225]
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Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Col1a1tm5(tetO-GFP/RNAi:Cdkn2a)Slowe/Col1a1+,Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sortm1(rtTA*M2)Jae,Krastm4Tyj/Kras+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm4(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(CAG-Mir22)Ppp/Col1a1tm1(CAG-Mir22)Ppp,Tg(Mx1-cre)1Cgn/0
Genetic Background: Not Specified

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm4(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(CAG-Mir22)Ppp/Col1a1tm1(CAG-Mir22)Ppp,Tg(Mx1-cre)1Cgn/0
Genetic Background: Not Specified

Allelic Composition: Col1a1tm2(tetO-IDH2*R140Q)Ppp/Col1a1tm2(tetO-IDH2*R140Q)Ppp,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-IDH2*R140Q)Ppp/Col1a1tm2(tetO-IDH2*R140Q)Ppp,Flt3tm1.1Dosm/Flt3tm1.1Dosm,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129 * C57BL/6

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Col1a1tm4(CAG-FGFR2_iIIIb*K660N)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Col1a1tm1(tetO-EWSR1/ATF1)Yasu/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-EWSR1/ATF1)Yasu/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Tg(CAG-cat-lacZ)11Miya/0,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J * DBA/2

Allelic Composition: Col1a1tm1(tetO-EWSR1/ATF1)Yasu/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(EYFP)Cos,Tg(Mpz-cre)94Imeg/0
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Col1a1tm5(tetO-GFP/RNAi:Cdkn2a)Slowe/Col1a1+,Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sortm1(rtTA*M2)Jae,Krastm4Tyj/Kras+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ApcMin/Apc+,Col1a1tm1(CAG-Sirt1)Dsin/Col1a1+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm3(CAG-IDH2*R140Q)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm3(tetO-Mirlet7g/Mir21)Gqda/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnq4tm1.2Tjj/Kcnq4+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Col1a1tm1(CAG-EGFR)Char/Col1a1tm1(CAG-EGFR)Char,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Col1a1tm2(CAG-EGFR*)Char/Col1a1tm2(CAG-EGFR*)Char,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Col1a1tm1(CAG-EGFR)Char/Col1a1tm2(CAG-EGFR*)Char,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm4(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm5(tetO-GFP/RNAi:Cdkn2a)Slowe/Col1a1+,Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sortm1(rtTA*M2)Jae,Krastm4Tyj/Kras+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1+,Tg(CMV-rtTA)4Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

Allelic Composition: Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Tg(CMV-rtTA)4Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

Allelic Composition: Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm10(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Tg(CMV-rtTA)4Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

Allelic Composition: Col1a1tm10(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm11(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm11(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Tg(CMV-rtTA)4Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1tm2(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm8(CAG-BDNF)Jae/Col1a1+,Mecp2tm1.1Jae/Y,Tg(Camk2a-cre)93Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-Yap1*)Lrsn/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-EWSR1/ATF1)Yasu/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-EML4/ALK)Kkw/Col1a1+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Col1a1tm3(CAG-IDH2*R140Q)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Col1a1tm3(CAG-IDH2*R140Q)Kkw/Col1a1+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Col1a1tm5(tetO-Jun/Fos)Wag/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Col1a1tm4(CAG-FGFR2_iIIIb*K660N)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Col1a1tm2(tetO-IDH2*R140Q)Ppp/Col1a1tm2(tetO-IDH2*R140Q)Ppp,Flt3tm1.1Dosm/Flt3tm1.1Dosm,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129 * C57BL/6

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: involves: 129X1/SvJ

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dmdmdx-4Cv/Dmdmdx-4Cv,Terctm1Rdp/Terctm1Rdp
Genetic Background: B6.Cg-Terctm1Rdp Dmdmdx-4Cv

 MP:0002115 abnormal skeleton extremities morphology "abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfe2l2tm1Ney/Nfe2l2tm1Ney,Nfe2l3tm1Vbl/Nfe2l3tm1Vbl
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Tg(ACTB-Edn1)1416Clou/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Col1a1tm1(tetO-GFP/RNAi:Rad21)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae/Col1a1tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-mCherry)Eggn/Col1a1tm1(tetO-mCherry)Eggn
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-GFP/RNAi:luc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm10(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm11(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-Vegfc)Mmul/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-cas9)Sho/Col1a1tm1(tetO-cas9)Sho
Genetic Background: B6.Cg-Col1a1tm1(tetO-cas9)Sho

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm8(CAG-BDNF)Jae/Col1a1+,Mecp2tm1.1Jae/Y,Tg(Camk2a-cre)93Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

 MP:0002187 abnormal fibula morphology "malformation of the lateral and smaller bone of the lower limb" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm3(CAG-IDH2*R140Q)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0002244 abnormal turbinate morphology "any structural anomaly of the bony plates of the lateral wall of the nasal cavity " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Col1a1tm3(tetO-Fosl1,-DsRed)Wag/Col1a1+,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

Allelic Composition: Col1a1tm2(tetO-Fosl2,-DsRed)Wag/Col1a1+,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

Allelic Composition: Col1a1tm4(tetO-Jun/Fosl2)Wag/Col1a1+,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

 MP:0002329 abnormal blood gas "anomaly in the amount of oxygen and carbon dioxide in the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: C3HeB/FeJ-Col1a1Aga2

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcrtm1(BCR/ABL)Tsr/Bcr+,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: C57BL/6

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: ApcMin/Apc+,Col1a1tm9(tetO-Dnmt3b_i1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

 MP:0002413 abnormal megakaryoblast morphology/development "anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm1(tetO-cre)Haho/?,Gfi1btm1.1Haho/Gfi1btm1.1Haho
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002452 abnormal antigen presenting cell physiology "impairment or abnormality of the function of cells involved in making antigen recognizable by lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdcp1tm1.2Moas/Cdcp1tm1.2Moas,Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1 * FVB/N * SJL

Allelic Composition: Col1a1tm1(tetO-Yod1*)Hpl/Col1a1tm1(tetO-Yod1*)Hpl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-Deptor)Dmsa/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

 MP:0002636 delayed vaginal opening "the opening of the genital canal in a female occuring at a later than expected age" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0002693 abnormal pancreas physiology "abberrant function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Col1a1tm2(tetO-Fosl2,-DsRed)Wag/Col1a1+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0002734 abnormal mechanical nociception "abnormal capability to sense pain elicited by mechanical stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col1a1tm3(CAG-IDH2*R140Q)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0002819 abnormal pulp cavity morphology "defects in the central hollow space of a tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

 MP:0002832 coarse hair "hair shafts that are twisted or coiled and are of uneven thickness produce an overall rugged or uneven appearance and roughness to the touch" [llw2:Linda Washburn , Mouse Genome Informatics Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:56826]
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0002865 increased growth rate "accelerated time to reach a developmental stage or stages" [J:32208, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm1(tetO-cre)Haho/?,Gfi1btm1.1Haho/Gfi1btm1.1Haho
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1tm2(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Col1a1tm2(tetO-LIN28B)Gqda/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Col1a1tm2(tetO-Fosl2,-DsRed)Wag/Col1a1+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0002904 increased circulating parathyroid hormone level "greater than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nfe2l2tm1Ney/Nfe2l2tm1Ney,Nfe2l3tm1Vbl/Nfe2l3tm1Vbl
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm3(tetO-Fosl1,-DsRed)Wag/Col1a1+,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

 MP:0002944 increased lactate dehydrogenase level "greater than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87714]
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Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002966 decreased circulating alkaline phosphatase level "reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Tg(Cebpb-tTA)#Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-Deptor)Dmsa/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

Allelic Composition: Col1a1tm3(tetO-Fosl1,-DsRed)Wag/Col1a1+,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm2(tetO-LIN28B)Gqda/Col1a1tm3(tetO-Mirlet7g/Mir21)Gqda,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Wt1tm2(cre/ERT2)Wtp/Wt1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0002993 arthritis "joint inflammation, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002999 abnormal bone healing "defects in the restoration of integrity to bone after trauma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Col1a1tm2(tetO-Fosl2,-DsRed)Wag/Col1a1+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1+,Tg(CMV-rtTA)4Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

Allelic Composition: Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Tg(CMV-rtTA)4Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

Allelic Composition: Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm10(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm11(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003089 reduced skin tensile strength "reduction in the normal maximum tension the skin can withstand without tearing" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:48068]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0003098 reduced tendon stiffness "decreased ability of tendon to maintain tensile strength and load" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:79915]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm3(CAG-IDH2*R140Q)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1tm2(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-cre)Haho/?,Gfi1btm1.1Haho/Gfi1btm1.1Haho
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0003213 resistance to age related obesity "reduced probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission]
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Col1a1tm3(CAG-IDH2*R140Q)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0003279 aneurysm "a protruding sac formed by the dilation of the wall of an artery, a vein, or the heart resulting from a weakening of the vessel wall or heart muscle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Kcnq4tm1.2Tjj/Kcnq4+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003326 liver failure "cessation of function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Col1a1tm3(tetO-Fosl1,-DsRed)Wag/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm3(tetO-Fosl1,-DsRed)Wag/Col1a1+,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

 MP:0003419 delayed endochondral bone ossification "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
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Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003427 parakeratosis "abnormal retention of the nuclei of the keratinocytes in the stratum corneum of the epidermis" [smb:Susan M Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-Ctnnb1*)Hoch/Col1a1tm2(tetO-Ctnnb1*)Hoch,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003450 enlarged pancreas "increase of the size of the pancreas compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003560 osteoarthritis "a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more joints" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95374]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0003643 spleen atrophy "wasting of the spleen resulting in reduced size" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apptm2.1Tcs/Apptm2.1Tcs,Casttm1Tcs/Casttm1Tcs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Col1a1tm2(tetO-LIN28B)Gqda/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Six2-EGFP/cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CD-1

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm1(tetO-CDKN2A)Ibp/Col1a1+,Tg(KRT5-rtTA)#Glk/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0003714 absence of platelets "lack of non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm1(tetO-cre)Haho/?,Gfi1btm1.1Haho/Gfi1btm1.1Haho
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: ApcMin/Apc+,Col1a1tm9(tetO-Dnmt3b_i1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

 MP:0003797 abnormal compact bone morphology "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Flt4tm1Ali/Flt4tm1Ali
Genetic Background: Not Specified

Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0003855 abnormal forelimb zeugopod morphology 
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Allelic Composition: Col1a1tm1(hs1473-PITX1)Smun/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003893 increased hepatocyte proliferation "anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Tg(Cebpb-tTA)#Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003953 abnormal hormone level "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

 MP:0004044 aortic dissection "a pathologic process, characterized by splitting of the media layer of the aorta, which leads to formation of a dissecting aneurysm" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Kcnq4tm1.2Tjj/Kcnq4+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm3(CAG-IDH2*R140Q)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0004091 abnormal Z lines "any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm3(CAG-IDH2*R140Q)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0004134 abnormal chest morphology "malformation of the part of the body between the neck and the abdomen " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:59168]
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Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-Yod1*)Hpl/Col1a1tm1(tetO-Yod1*)Hpl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0004506 abnormal pubic bone morphology "any structural anomaly in the forward portion of either of the hipbones, at the juncture forming the front arch of the pelvis" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0004507 abnormal ischium morphology "any structural anomaly of the lowest of the three major bones that constitute each half of the pelvis, distinct at birth but later becoming fused with the ilium and pubis" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0004509 abnormal pelvic girdle bone morphology "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0004674 thin ribs "a more slender appearance of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

 MP:0004675 rib fractures "a crack or break in the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Col1a1tm1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: C3HeB/FeJ-Col1a1Aga2

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0004703 abnormal vertebral column "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0004706 short vertebral body "reduced length of the main cylindrical portion of the vertebra ventral to the vertebral canal" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Col1a1tm1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: involves: 129X1/SvJ

 MP:0004748 increased susceptibility to age-related hearing loss "greater than normal loss of hearing associated with advancing age, manifest as reduced ability to perceive or discriminate sounds; the pattern and age of onset vary" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Flt4tm1Ali/Flt4tm1Ali
Genetic Background: Not Specified

 MP:0004789 increased bile salt level "increased concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm3(tetO-Fosl1,-DsRed)Wag/Col1a1+,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-GFP/RNAi:Rad21)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(CAG-Mir22)Ppp/Col1a1tm1(CAG-Mir22)Ppp,Tg(Mx1-cre)1Cgn/0
Genetic Background: Not Specified

Allelic Composition: Col1a1tm1(tetO-GFP/RNAi:Rad21)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-Irf4)Sing/Col1a1tm1(tetO-Irf4)Sing,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Irf4tm1Mak/Irf4+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-Irf4)Sing/Col1a1tm1(tetO-Irf4)Sing,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Irf4tm1Mak/Irf4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Col1a1tm2(tetO-Ctnnb1*)Hoch/Col1a1tm2(tetO-Ctnnb1*)Hoch,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J

 MP:0004842 abnormal large intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Col1a1tm2(tetO-Ctnnb1*)Hoch/Col1a1tm2(tetO-Ctnnb1*)Hoch,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm2(tetO-Fosl2,-DsRed)Wag/Col1a1+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm2(tetO-Fosl2,-DsRed)Wag/Col1a1+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0004986 abnormal osteoblast morphology "any structural anomaly of a bone-forming cell, which normally forms an osseous matrix (osteoid) in which it becomes enclosed as an osteocyte" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Col1a1tm2(tetO-Fosl2,-DsRed)Wag/Col1a1+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0004988 increased osteoblast cell number "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0004991 decreased bone strength "reduced ability of bone to endure the application of force without yielding or breaking" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0004992 increased bone resorption "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Col1a1tm2(tetO-Fosl2,-DsRed)Wag/Col1a1+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1tm2(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm1(tetO-GFP/RNAi:Rad21)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm3(CAG-IDH2*R140Q)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0005141 liver hyperplasia "increased size of liver due to increased hepatocyte cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33827]
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Tg(Cebpb-tTA)#Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: ApcMin/Apc+,Col1a1tm1(CAG-Sirt1)Dsin/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

Allelic Composition: Col1a1tm5(tetO-GFP/RNAi:Cdkn2a)Slowe/Col1a1+,Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sortm1(rtTA*M2)Jae,Krastm4Tyj/Kras+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Itga8tm1.1Rdav/Itga8tm1.1Rdav,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA

Allelic Composition: Col1a1tm3(tetO-Fosl1,-DsRed)Wag/Col1a1+,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm3(tetO-Fosl1,-DsRed)Wag/Col1a1+,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm3(tetO-Fosl1,-DsRed)Wag/Col1a1+,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm3(CAG-IDH2*R140Q)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Col1a1tm3(tetO-Fosl1,-DsRed)Wag/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005258 ocular hypertension "abnormal elevation of the intraocular pressure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nfe2l2tm1Ney/Nfe2l2tm1Ney,Nfe2l3tm1Vbl/Nfe2l3tm1Vbl
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Col1a1tm2(tetO-LIN28B)Gqda/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Col1a1tm2(tetO-Fosl2,-DsRed)Wag/Col1a1+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col1a1tm3(tetO-Mirlet7g/Mir21)Gqda/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Col1a1tm3(tetO-Fosl1,-DsRed)Wag/Col1a1+,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

 MP:0005296 abnormal humerus morphology "malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm1(hs1473-PITX1)Smun/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm1(tetO-Deptor)Dmsa/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0005324 ascites "accumulation or retention of fluid within the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm3(tetO-Fosl1,-DsRed)Wag/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: C3HeB/FeJ-Col1a1Aga2

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm3(tetO-Fosl1,-DsRed)Wag/Col1a1+,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm8(CAG-BDNF)Jae/Col1a1+,Mecp2tm1.1Jae/Y,Tg(Camk2a-cre)93Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA/J

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0005493 stomach epithelial hyperplasia 
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1tm1(tetO-CDKN2A)Ibp/Col1a1+,Tg(KRT5-rtTA)#Glk/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1tm2(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Col1a1tm3(tetO-Fosl1,-DsRed)Wag/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Col1a1tm3(tetO-Mirlet7g/Mir21)Gqda/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Col1a1tm2(tetO-Fosl2,-DsRed)Wag/Col1a1+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: C3HeB/FeJ-Col1a1Aga2

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Atp1a3tm1.1Kwk/Atp1a3+
Genetic Background: B6JJcl.Cg-Atp1a3tm1.1Kwk

 MP:0005645 abnormal hypothalamus physiology "anomalous function of the ventral and medial region of the diencephalon forming the walls of the ventral half of the third ventricle, which is normally involved in the functions of the autonomic (visceral motor) nervous system and, through its vascular link with the anterior lobe of the pituitary gland, in endocrine mechanisms" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nr3c1tm1.1Mvc/Nr3c1+,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129 * C57BL/6 * FVB

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm1(tetO-Deptor)Dmsa/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Col1a1tm2(tetO-LIN28B)Gqda/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Col1a1tm1(tetO-Deptor)Dmsa/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm3(CAG-IDH2*R140Q)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Col1a1tm3(CAG-IDH2*R140Q)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0006054 spinal hemorrhage "bleeding into the spine" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

 MP:0006113 abnormal heart septum morphology "abnormality in the wall between the atria or ventricles of the heart, usually incomplete closure" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: C3HeB/FeJ-Col1a1Aga2

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Flt4tm1Ali/Flt4tm1Ali
Genetic Background: Not Specified

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm10(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm11(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-CDKN2A)Ibp/Col1a1+,Tg(KRT5-rtTA)#Glk/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-EML4/ALK)Kkw/Col1a1+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Col1a1tm4(CAG-FGFR2_iIIIb*K660N)Kkw/Col1a1+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Col1a1tm4(CAG-FGFR2_iIIIb*K660N)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0008025 brain vacuoles "the abnormal presence of cavities or fluid-filled vesicles in the soma of brain cells, often indicative of spongiosis or other pathological states" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm3(CAG-IDH2*R140Q)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0008099 abnormal plasma cell differentiation "atypical production of or inability to produce terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-Irf4)Sing/Col1a1tm1(tetO-Irf4)Sing,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Irf4tm1Mak/Irf4+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-Irf4)Sing/Col1a1tm1(tetO-Irf4)Sing,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+,Irf4tm1Mak/Irf4tm1Mak
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008121 increased myeloid dendritic cell number "greater number of phagocytic cells of the myeloid lineage that capture antigens in the periphery and then migrate to the lymphoid organs and secrete cytokines to initiate immune responses" [PMID:10449155, PMID:9521319]
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Allelic Composition: Col1a1tm1(CAG-Mir22)Ppp/Col1a1tm1(CAG-Mir22)Ppp,Tg(Mx1-cre)1Cgn/0
Genetic Background: Not Specified

 MP:0008152 decreased diameter of femur "reduced width of the cross-sectional distance that extends from one lateral edge of the femur, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0008177 increased germinal center B cell number "greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Col1a1tm1(CAG-Ezh2*)Meln/Col1a1+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008246 abnormal leukocyte morphology "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008255 decreased megakaryocyte cell number "reduced number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008256 abnormal myometrium morphology "any structural anomaly of the smooth muscle coat of the uterus, which forms the main mass of the organ and surrounds and supports the endometrium" [MESH:A02.633.570.500, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptx3tm1Mant/Ptx3tm1Mant
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0008275 failure of endochondral bone ossification "failure to initiate or a block in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]
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Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008392 decreased primordial germ cell number "reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lin28atm1.1Gqda/Lin28atm1.1Gqda
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0008395 abnormal osteoblast differentiation "atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfe2l2tm1Ney/Nfe2l2tm1Ney,Nfe2l3tm1Vbl/Nfe2l3tm1Vbl
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0008438 abnormal cutaneous collagen fibril morphology "any structural anomaly of the connective tissue bundles in the extracellular matrix of skin tissue that are composed of collagen, and play a role in skin strength and elasticity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008481 increased spleen germinal center number "greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Col1a1tm1(CAG-Ezh2*)Meln/Col1a1+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008483 increased spleen germinal center size "greater size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Col1a1tm1(CAG-Ezh2*)Meln/Col1a1+,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Col1a1tm3(tetO-Fosl1,-DsRed)Wag/Col1a1+,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

 MP:0008714 lung carcinoma "a malignant neoplasm of the ling, arising from epithelial cells, usually glandular or squamous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-EML4/ALK)Kkw/Col1a1+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129 * C57BL/6

 MP:0008753 abnormal osteocyte morphology "any structural anomaly of a mature osteoblast that has become embedded in the bone matrix (osteoid) in small cavities called lacuna and is connected to adjacent osteocytes via protoplasmic projections called canaliculi" [MESH:A.11.329.629.500]
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Allelic Composition: Nfe2l2tm1Ney/Nfe2l2tm1Ney,Nfe2l3tm1Vbl/Nfe2l3tm1Vbl
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0008806 increased circulating amylase level "greater concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066]
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Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008877 abnormal DNA methylation "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
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Allelic Composition: ApcMin/Apc+,Col1a1tm9(tetO-Dnmt3b_i1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-CTNNB1)Tcd/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

 MP:0008884 abnormal enterocyte apoptosis "change in the timing or the number of enterocytes undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-CTNNB1)Tcd/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

 MP:0008885 increased enterocyte apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-CTNNB1)Tcd/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

 MP:0008891 decreased hepatocyte apoptosis "reduction in the number of hepatocytes undergoing programmed cell death" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Tg(Cebpb-tTA)#Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008915 fused carpal bones "anomaly of the nine nodular bones of the joint between the forelimb bones and the front paws/hands resulting in some or all the bones being joined together" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Col1a1tm1(hs1473-PITX1)Smun/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008941 reticulocytopenia "decrease in the normal number of circulating reticulocytes" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1tm2(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm10(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm11(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008976 delayed female fertility "ability of a female organism to produce live offspring occurring at a later than expected age" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0009004 progressive hair loss "thinning of hair (coat) over time, usually in a defined pattern, until entirely gone with no recurrent growth" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm4(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009159 increased pancreatic acinar cell number "increased number of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0009220 prostate adenocarcinoma "malignant neoplasm arising from prostate tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm2(tetO-Fosl2,-DsRed)Wag/Col1a1+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm2(tetO-Fosl2,-DsRed)Wag/Col1a1+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm3(tetO-Fosl1,-DsRed)Wag/Col1a1+,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

Allelic Composition: Col1a1tm2(tetO-Fosl2,-DsRed)Wag/Col1a1+,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

Allelic Composition: Col1a1tm4(tetO-Jun/Fosl2)Wag/Col1a1+,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

 MP:0009378 abnormal endoplasmic reticulum morphology "any structural anomaly of irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells" [GO:0005783]
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Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: C3HeB/FeJ-Col1a1Aga2

 MP:0009412 skeletal muscle fiber degeneration "pathological deterioration of skeletal muscle fiber tissue, often accompanied by loss of function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0009414 skeletal muscle fiber necrosis "pathological cell death in the skeletal muscle fibers, usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0009420 skeletal muscle endomysial fibrosis "replacement of the layer of connective tissue that ensheaths a muscle fiber by fibrous tissue resulting in separation of individual fibers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0009704 skin squamous cell carcinoma "a skin carcinoma derived from stratified squamous epithelium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm6(tetO-MSI2)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009785 altered susceptibility to infection induced morbidity/mortality "differences from the expected moribund state caused by a pathogenic invasion or from components of or toxins produced by pathogens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Evc2tm2.1Mis/Evc2tm2.1Mis,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0009862 abnormal aorta elastic tissue morphology "any structural anomaly of the dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcnq4tm1.2Tjj/Kcnq4+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009871 abnormal aorta tunica adventitia morphology "any structural anomaly of the outermost layer of the aorta wall, containing connective tissue and collagen and elastic fibers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Kcnq4tm1.2Tjj/Kcnq4+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0010099 abnormal thoracic cage shape "anomaly in the overall regular dome shape of the ribcage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-SOX2)Mjm/Col1a1+,Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J

Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J

 MP:0010156 abnormal small intestinal crypt cell physiology "altered function of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine" [MGI:jbubier "Jason Bubier, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm10(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm11(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm17(tetO-GFP,-cas9*)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm19(tetO-GFP,-cas9*)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm20(tetO-GFP,-cas9*D10A)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010157 abnormal small intestinal crypt cell proliferation "anomaly in the ability of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine to undergo expansion by cell division" [MGI:jbubier "Jason Bubier, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm10(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm11(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm17(tetO-GFP,-cas9*)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm19(tetO-GFP,-cas9*)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm20(tetO-GFP,-cas9*D10A)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010158 abnormal intestine development "abnormal formation of the digestive tube passing from the stomach to the anus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-CTNNB1)Tcd/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

 MP:0010279 increased gastrointestinal tumor incidence "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apc+,Col1a1tm1(CAG-Sirt1)Dsin/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

 MP:0010294 increased kidney tumor incidence "greater than the expected number of tumors originating in the kidney in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm2(tetO-LIN28B)Gqda/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Wt1tm2(cre/ERT2)Wtp/Wt1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010357 increased prostate gland tumor incidence "greater than the expected number of neoplams in the prostate gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010398 decreased liver glycogen level "less than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-Tcfap2c)Hsc/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010401 increased skeletal muscle glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm3(CAG-IDH2*R140Q)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0010508 abnormal heart electrocardiography waveform feature "any anomaly in the pattern of the graphic record of the integrated action currents of the cardiac cycle represented as changes in voltage; the prominent waves in the ECG correspond to specific conduction activity in areas of the heart and the timing and amplitude of ECG waveforms provide valuable information about heart rate and rhythm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:20410536]
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Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: C3HeB/FeJ-Col1a1Aga2

 MP:0010537 tumor regression "a decrease in tumor size from a formerly larger state and/or a decrease in the extent of tumors in the body" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-EWSR1/ATF1)Yasu/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010633 myocardial hypertrophy "an increase in size of the myocardium, not due to increased cell number" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0010634 increased QRS amplitude "increased in the size (height or maximum displacement) of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction, suggesting ventricular excitation defects" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: C3HeB/FeJ-Col1a1Aga2

 MP:0010639 altered tumor pathology "any changes associated with the chemistry, immunohistology, cellular alterations or environmental interactions of tumors compared to the expected state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm1(tetO-EML4/ALK)Kkw/Col1a1+,Tg(Scgb1a1-rtTA)1Jaw/0
Genetic Background: involves: 129 * C57BL/6

 MP:0010727 increased glioblastoma incidence "greater than the expected number of a fast-growing type of central nervous system tumor that forms from glial tissue of the brain and spinal cord and has cells that look very different from normal cells; glioblastoma usually occurs in adults and affects the brain more often than the spinal cord" [NCI:CDRID45698 "http://www.cancer.gov/dictionary/?CdrID=45698"]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Col1a1tm1(CAG-EGFR)Char/Col1a1tm1(CAG-EGFR)Char,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Col1a1tm2(CAG-EGFR*)Char/Col1a1tm2(CAG-EGFR*)Char,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Col1a1tm1(CAG-EGFR)Char/Col1a1tm2(CAG-EGFR*)Char,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

 MP:0010784 abnormal forestomach morphology "any structural anomaly of the dilated area of tissue where the stomach and esophagus meet" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-Fos)Wag/Col1a1+,Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0010792 abnormal stomach mucosa morphology "any structural anomaly of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010796 abnormal intermediate gastric gland morphology "any structural anomaly of any of the branched tubular glands in the mucosa of the fundus and body of the stomach that secrete most of the digestive substances secreted by the stomach" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010867 abnormal bone trabecula morphology "any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm2(tetO-Fosl2,-DsRed)Wag/Col1a1+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0010875 increased bone volume "increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm2(tetO-Fosl2,-DsRed)Wag/Col1a1+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0010876 decreased bone volume "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0010909 pulmonary alveolar hemorrhage "bleeding into the small sac-like dilations of the distal airspace of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: C3HeB/FeJ-Col1a1Aga2

 MP:0010970 abnormal compact bone lamellar structure "any structural anomaly of the concentric layers of calcified matrix interspersed with osteocytes lodged in lacunae between the lamellae that comprise the cylindrical osteons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Flt4tm1Ali/Flt4tm1Ali
Genetic Background: Not Specified

Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0010985 abnormal kidney mesenchyme morphology "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing kidney" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm2(tetO-LIN28B)Gqda/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Wt1tm2(cre/ERT2)Wtp/Wt1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0011004 abnormal epidermal stem cell morphology "any structural anomaly of a somatic stem cell that is part of the epidermis" [CL:1000428]
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Col1a1tm1(tetO-cre)Haho/?,Gfi1btm1.1Haho/Gfi1btm1.1Haho
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: C3HeB/FeJ-Col1a1Aga2

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Col1a1tm1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

Allelic Composition: Col1a1tm10(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm11(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Runx3tm3.1Yg/Runx3tm3.1Yg
Genetic Background: Not Specified

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Scn5atm1Care/Scn5a+
Genetic Background: FVB.129P2-Scn5atm1Care

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Ightm1.1Fwa/Ightm1.1Fwa,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Col1a1tm3(CAG-IDH2*R140Q)Kkw/Col1a1+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Pax1Un-s/Pax1Un-s
Genetic Background: B6.CC57BR-Pax1Un-s

 MP:0011182 decreased hematopoietic cell number "fewer than expected number of cells of the hematopoietic lineage" [MGI:csmith]
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Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1tm1(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm1(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1tm2(tetO-RNAi:Rps19)Karl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-RNAi:Rps19)Karl/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011585 decreased alkaline phosphatase activity "reduced ability to catalyze the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum" [GO:0004035]
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011629 decreased mitochondria number "fewer than normal number of the cellular organelles responsible for energy production" [MGI:csmith]
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Allelic Composition: Col1a1tm3(CAG-IDH2*R140Q)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0011635 abnormal mitochondrial crista morphology "Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria" [GO:0030061]
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Allelic Composition: Col1a1tm3(CAG-IDH2*R140Q)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0011642 abnormal bone collagen fibril morphology "any structural anomaly of the connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity" [MGI:csmith]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0011643 abnormal tendon collagen fibril morphology "any structural anomaly of the connective tissue bundles in the extracellular matrix of tendon tissue that are composed of collagen, and play a role in tissue strength and elasticity" [MGI:csmith]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Col1a1tm1(tetO-EWSR1/ATF1)Yasu/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011901 abnormal hematopoietic stem cell proliferation "anomaly in the ability of a hematopoietic stem cell population to undergo expansion by cell division" [MGI:csmith]
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Allelic Composition: Col1a1tm2(tetO-IDH2*R140Q)Ppp/Col1a1tm2(tetO-IDH2*R140Q)Ppp,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011902 increased hematopoietic stem cell proliferation "increase in the expansion rate of a hematopoietic stem cell population by cell division" [MGI:csmith]
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Allelic Composition: Col1a1tm2(tetO-IDH2*R140Q)Ppp/Col1a1tm2(tetO-IDH2*R140Q)Ppp,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011922 abnormal circulating osteocalcin level "aberrant concentration in the blood of this hormone secreted by osteoblasts which are found in bone and dentin" [MPD:Molly]
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Allelic Composition: Col1a1tm2(tetO-Fosl2,-DsRed)Wag/Col1a1+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0012207 decreased neuronal stem cell self-renewal "an decreased rate in the process by which stem cells divide and proliferate to make more stem cells, perpetuating an decrease in the stem cell pool; self-renewal is division with maintenance of the undifferentiated state" [PMID:19575646]
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Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm4(tetO-GFP/RNAi:Apc)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0013138 thin body "lean or slender in form" [MGI:Ahmad_Retha]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0013221 pancreatic acinar-to-ductal metaplasia "a reprogramming event that induces transdifferentiation of pancreatic acinar cells to a duct-like phenotype in response to inflammatory injury; ADM is associated with an increased risk of exocrine pancreatic cancer and is considered a precursor of pancreatic ductal adenocarcinoma" [MGI:anna]
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0013258 abnormal extracellular matrix morphology "any structural anomaly of the structure lying external to one or more cells, which provides structural support for cells or tissues; in mammals, the extracellular matrix is completely external to the cell " [GO:0031012]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0013304 osteophytes "bony projections that form along joint margins at bone edges, including the spine; these are frequently found in areas affected by arthritis such as the disc or joint spaces where cartilage has deteriorated" [MGI:mlaw]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0013481 abnormal ileum crypts of Lieberkuhn morphology "any structural anomaly of the intestinal crypts located in the mucosa of the ileum, the portion of the small intestine that extends from the jejunum to the colon" [MGI:Anna]
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Allelic Composition: Col1a1tm1(tetO-SOX2)Mjm/Col1a1+,Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J

 MP:0013630 increased bone trabecular spacing "increase in the amount of space between trabeculae in cancellous bone" [MGI:jwhite]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0013631 decreased bone trabecular spacing "decrease in the amount of space between trabeculae in cancellous bone" [MGI:jwhite]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0013663 increased myeloid cell number "greater than the expected number of cells of the myeloid lineage" [CL:0000763]
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Allelic Composition: Col1a1tm1(tetO-GFP/RNAi:Rad21)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0013696 increased granulocyte monocyte progenitor cell number "increase in the number of a hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages; these cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1" [CL:0000557, PMID:16551251]
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Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0013805 myeloid metaplasia "a progressive disease of the bone marrow where neoplastic bone marrow stem cells lodge and grow at sites outside the bone marrow, and the marrow is replaced by fibrous (scar) tissue; may lead to anemia, enlarged spleen, the presence of nucleated red blood cells and immature granulocytes in the blood, and the occurrence of extramedullary hematopoiesis in the spleen and liver" [ISBN:0781727286]
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Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0014071 increased cardiac muscle glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in heart muscle" [MGI:Anna]
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Allelic Composition: Col1a1tm2(CAG-IDH2*R172K)Kkw/Col1a1+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/c * C57BL/6

 MP:0014076 absent Paneth cells "absence or loss of the large secretory cells containing coarse granules normally confined to the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna]
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0014077 ectopic Paneth cells "abnormal position of the large secretory cells containing coarse granules normally confined to the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna]
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Allelic Composition: Col1a1tm1(tetO-SOX2)Mjm/Col1a1+,Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J

Allelic Composition: Col1a1tm17(tetO-GFP,-cas9*)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm19(tetO-GFP,-cas9*)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col1a1tm20(tetO-GFP,-cas9*D10A)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0020039 increased bone ossification "increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Col1a1tm2(tetO-Fosl2,-DsRed)Wag/Col1a1+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0020040 decreased bone ossification "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Fgfr1tm5.2Sor/Fgfr1tm5.2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0020137 decreased bone mineralization "decrease in the rate at which minerals are deposited into bone" []
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Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

 MP:0020254 decreased collagen level "decreased level of the main structural protein of the various connective tissues in animals" [GOC:NV, PMID:11704682]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0030069 broad face "increased width of the upper and lower face" [MGI:anna]
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Allelic Composition: Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0030278 thick neurocranium "increased thickness of the bones of the skull enclosing the brain" [MGI:anna]
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Allelic Composition: Nfe2l2tm1Ney/Nfe2l2tm1Ney,Nfe2l3tm1Vbl/Nfe2l3tm1Vbl
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0030279 thin neurocranium "decreased thickness of the bones of the skull enclosing the brain" [MGI:anna]
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Allelic Composition: Col1a1tm1.1Jcm/Col1a1+
Genetic Background: either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)

Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0030441 increased osteoblast apoptosis "increase in the number of osteoblasts undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Nfe2l2tm1Ney/Nfe2l2tm1Ney,Nfe2l3tm1Vbl/Nfe2l3tm1Vbl
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Col1a1Aga2/Col1a1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0030451 abnormal dentin mineralization "anomaly in the process by which calcium salts are deposited into dentin" [GO:0097188]
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Allelic Composition: Col1a1M1Jrt/Col1a1+
Genetic Background: involves: C3H/HeJ * C57BL/6J * FVB/NJ

 MP:0030479 increased osteocyte apoptosis "increase in the number of osteocytes undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Nfe2l2tm1Ney/Nfe2l2tm1Ney,Nfe2l3tm1Vbl/Nfe2l3tm1Vbl
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0030484 abnormal osteocyte lacuna morphology "any structural anomaly of the small cavity within the bone matrix that is occupied by an osteocyte cell body, and from which slender canaliculi radiate and penetrate the adjacent lamellae to anastomose with the canaliculi of neighboring lacunae, thus forming a system of cavities interconnected by minute canals" [https://medical-dictionary.thefreedictionary.com/osteocyte+lacuna]
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Allelic Composition: Nfe2l2tm1Ney/Nfe2l2tm1Ney,Nfe2l3tm1Vbl/Nfe2l3tm1Vbl
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029661 Col1a2 / Q01149 / Collagen alpha-2(I) chain / P08123* / collagen type I alpha 2 chain*  / - / reaction / complex
 ENSMUSG00000001506 Col1a1 / P11087 / Collagen alpha-1(I) chain / P02452* / collagen type I alpha 1 chain*  / reaction / complex / -
 ENSMUSG00000019916 P4ha1 / Q60715 / Prolyl 4-hydroxylase subunit alpha-1 / P13674*  / reaction
 ENSMUSG00000018906 P4ha2 / Q60716 / Prolyl 4-hydroxylase subunit alpha-2 / O15460*  / reaction
 ENSMUSG00000025130 P4hb / P09103 / prolyl 4-hydroxylase, beta polypeptide / P07237* / prolyl 4-hydroxylase subunit beta*  / reaction / complex
 ENSMUSG00000051048 P4ha3 / prolyl 4-hydroxylase subunit alpha 3 / Q7Z4N8*  / reaction






 

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