ENSDARG00000012405


Danio rerio

Features
Gene ID: ENSDARG00000012405
  
Biological name :col1a1a
  
Synonyms : col1a1a / collagen, type I, alpha 1a
  
Possible biological names infered from orthology : COL1A1 / Collagen alpha-1(I) chain / collagen type I alpha 1 chain / P02452 / P11087
  
Species: Danio rerio
  
Chr. number: 3
Strand: 1
Band:
Gene start: 23221047
Gene end: 23239458
  
Corresponding Affymetrix probe sets: Dr.20097.1.S1_s_at (Zebrafish Array)   DrAffx.2.1.S1_at (Zebrafish Array)   DrAffx.2.1.S1_s_at (Zebrafish Array)   NM_199214_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000003177
NCBI entrez gene - 337158     See in Manteia.
RefSeq - NM_199214
RefSeq Peptide - NP_954684
swissprot - F1QJC9
ZFIN ID - ZDB-GENE-030131-9102
Ensembl - ENSDARG00000012405
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 COL1A1ENSG00000108821Homo sapiens
 Col1a1ENSMUSG00000001506Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
col1a1b / collagen, type I, alpha 1b / COL1A1* / P02452* / P11087* / Collagen alpha-1(I) chain * / collagen type I alpha 1 chain*ENSDARG0000003580977
col2a1a / collagen, type II, alpha 1a / COL2A1* / P02458* / P28481* / collagen type II alpha 1 chain* / Collagen alpha-1(II) chain Collagen alpha-1(II) chain Chondrocalcin*ENSDARG0000006909370
col2a1b / collagen, type II, alpha 1b / COL2A1* / P02458* / collagen type II alpha 1 chain*ENSDARG0000001140764
col5a2a / collagen, type V, alpha 2a / COL5A2* / P05997* / Q3U962* / Collagen alpha-2(V) chain * / collagen type V alpha 2 chain*ENSDARG0000003167858
col1a2 / collagen, type I, alpha 2 / Q01149* / P08123* / Collagen alpha-2(I) chain * / collagen type I alpha 2 chain*ENSDARG0000002000758
col5a2b / collagen, type V, alpha 2b / COL5A2* / P05997* / Q3U962* / Collagen alpha-2(V) chain * / collagen type V alpha 2 chain*ENSDARG0000002484754
col5a1 / procollagen, type V, alpha 1 / O88207* / P20908* / Collagen alpha-1(V) chain * / collagen type V alpha 1 chain*ENSDARG0000001259343
col11a1a / collagen, type XI, alpha 1a / Q61245* / P12107* / COL11A1* / Collagen alpha-1(XI) chain * / collagen type XI alpha 1 chain*ENSDARG0000002616543
col11a2 / collagen, type XI, alpha 2 / Q64739* / P13942* / Collagen alpha-2(XI) chain * / collagen type XI alpha 2 chain*ENSDARG0000001242243
col11a1b / collagen, type XI, alpha 1b / Q61245* / P12107* / COL11A1* / Collagen alpha-1(XI) chain * / collagen type XI alpha 1 chain*ENSDARG0000000901442
col5a3a / collagen, type V, alpha 3a / COL5A3* / P25940* / collagen, type V, alpha 3* / collagen type V alpha 3 chain*ENSDARG0000009829442
col5a3b / collagen, type V, alpha 3b / COL5A3* / P25940* / collagen, type V, alpha 3* / collagen type V alpha 3 chain*ENSDARG0000010181641
si:ch211-196i2.1ENSDARG0000000791238
si:dkey-21p1.3ENSDARG0000000229532
si:dkey-61l1.4ENSDARG0000009256731
col27a1b / collagen, type XXVII, alpha 1b / Q8IZC6* / Q5QNQ9* / COL27A1* / Collagen alpha-1(XXVII) chain * / collagen type XXVII alpha 1 chain*ENSDARG0000009993025
si:ch1073-286c18.5ENSDARG000000985671


Protein motifs (from Interpro)
Interpro ID Name
 IPR000885  Fibrillar collagen, C-terminal
 IPR001007  VWFC domain
 IPR008160  Collagen triple helix repeat
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030278 regulation of ossification IMP
 biological_processGO:0031101 fin regeneration IMP
 biological_processGO:0033333 fin development IMP
 biological_processGO:0033334 fin morphogenesis IMP
 biological_processGO:0033339 pectoral fin development IMP
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0005201 extracellular matrix structural constituent IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Collagen degradation
Extracellular matrix organization
Collagen biosynthesis and modifying enzymes
Assembly of collagen fibrils and other multimeric structures
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Anchoring fibril formation
Crosslinking of collagen fibrils
Non-integrin membrane-ECM interactions
ECM proteoglycans
Platelet Adhesion to exposed collagen
MET activates PTK2 signaling
Collagen chain trimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000040 median fin fold median fin fold decreased length , abnormal
median fin fold undulate , abnormal
median fin fold decreased size , abnormal
Show

 ZFA:0000076 swim bladder swim bladder quality , abnormal
Show

 ZFA:0000108 fin fin deformed , abnormal
fin undulate , abnormal
fin malformed , abnormal
fin decreased size , abnormal
Show

 ZFA:0000126 centrum centrum ossification delayed , abnormal
Show

 ZFA:0000292 surface structure surface structure quality , abnormal
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 ZFA:0000434 skeletal system skeletal system quality , abnormal
Show

 ZFA:0000538 rib rib deformed , abnormal
Show

 ZFA:0001058 caudal fin caudal fin morphology , abnormal
caudal fin morphology , ameliorated
Show

 ZFA:0001069 ventral fin fold ventral fin fold decreased size , abnormal
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 ZFA:0001094 whole organism whole organism shape , abnormal
whole organism decreased length , abnormal
Show

 ZFA:0001114 head head flattened , abnormal
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 ZFA:0001115 trunk trunk shortened , abnormal
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 ZFA:0001161 pectoral fin pectoral fin undulate , abnormal
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 ZFA:0001184 pelvic fin pelvic fin atrophied , abnormal
pelvic fin kinked , abnormal
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 ZFA:0001189 vertebra vertebra decreased mass density , abnormal
vertebra fused with vertebra , abnormal
vertebra composition , abnormal
vertebra deformed , abnormal
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 ZFA:0001336 neural spine neural spine sloped , abnormal
neural spine sloped , ameliorated
Show

 ZFA:0001554 lepidotrichium lepidotrichium decreased mass density , abnormal
lepidotrichium increased thickness , abnormal
lepidotrichium malformed , abnormal
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 ZFA:0005435 actinotrichium actinotrichium absent , abnormal
actinotrichium malformed , abnormal
actinotrichium decreased amount , abnormal
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 ZFA:0005621 bone tissue bone tissue collagen type I trimer physical quality , abnormal
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 ZFA:0009031 osteoblast osteoblast endoplasmic reticulum lumen increased size , abnormal
osteoblast endoplasmic reticulum lumen size , ameliorated
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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