ENSDARG00000069093


Danio rerio

Features
Gene ID: ENSDARG00000069093
  
Biological name :col2a1a
  
Synonyms : col2a1a / collagen, type II, alpha 1a
  
Possible biological names infered from orthology : COL2A1 / Collagen alpha-1(II) chain Collagen alpha-1(II) chain Chondrocalcin / collagen type II alpha 1 chain / P02458 / P28481
  
Species: Danio rerio
  
Chr. number: 8
Strand: 1
Band:
Gene start: 21195420
Gene end: 21219473
  
Corresponding Affymetrix probe sets: Dr.3761.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000091007
Ensembl peptide - ENSDARP00000085740
NCBI entrez gene - 562496     See in Manteia.
RefSeq - XM_005166863
swissprot - Q2LDA1
swissprot - B3DLK0
ZFIN ID - ZDB-GENE-980526-192
Ensembl - ENSDARG00000069093
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 COL2A1ENSG00000139219Homo sapiens
 Col2a1ENSMUSG00000022483Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
col2a1b / collagen, type II, alpha 1b / COL2A1* / P02458* / collagen type II alpha 1 chain*ENSDARG0000001140773
col1a1a / collagen, type I, alpha 1a / COL1A1* / P02452* / P11087* / Collagen alpha-1(I) chain * / collagen type I alpha 1 chain*ENSDARG0000001240568
col1a1b / collagen, type I, alpha 1b / COL1A1* / P02452* / P11087* / Collagen alpha-1(I) chain * / collagen type I alpha 1 chain*ENSDARG0000003580966
col5a2a / collagen, type V, alpha 2a / COL5A2* / P05997* / Q3U962* / Collagen alpha-2(V) chain * / collagen type V alpha 2 chain*ENSDARG0000003167864
col1a2 / collagen, type I, alpha 2 / Q01149* / P08123* / Collagen alpha-2(I) chain * / collagen type I alpha 2 chain*ENSDARG0000002000758
col5a2b / collagen, type V, alpha 2b / COL5A2* / P05997* / Q3U962* / Collagen alpha-2(V) chain * / collagen type V alpha 2 chain*ENSDARG0000002484758
col11a2 / collagen, type XI, alpha 2 / Q64739* / P13942* / Collagen alpha-2(XI) chain * / collagen type XI alpha 2 chain*ENSDARG0000001242243
col11a1a / collagen, type XI, alpha 1a / Q61245* / P12107* / COL11A1* / Collagen alpha-1(XI) chain * / collagen type XI alpha 1 chain*ENSDARG0000002616543
col5a1 / procollagen, type V, alpha 1 / O88207* / P20908* / Collagen alpha-1(V) chain * / collagen type V alpha 1 chain*ENSDARG0000001259343
col5a3a / collagen, type V, alpha 3a / COL5A3* / P25940* / collagen, type V, alpha 3* / collagen type V alpha 3 chain*ENSDARG0000009829442
col11a1b / collagen, type XI, alpha 1b / Q61245* / P12107* / COL11A1* / Collagen alpha-1(XI) chain * / collagen type XI alpha 1 chain*ENSDARG0000000901442
col5a3b / collagen, type V, alpha 3b / COL5A3* / P25940* / collagen, type V, alpha 3* / collagen type V alpha 3 chain*ENSDARG0000010181641
si:ch211-196i2.1ENSDARG0000000791237
si:dkey-61l1.4ENSDARG0000009256730
si:dkey-21p1.3ENSDARG0000000229530
col27a1b / collagen, type XXVII, alpha 1b / Q8IZC6* / Q5QNQ9* / COL27A1* / Collagen alpha-1(XXVII) chain * / collagen type XXVII alpha 1 chain*ENSDARG0000009993024
si:ch1073-286c18.5ENSDARG000000985671


Protein motifs (from Interpro)
Interpro ID Name
 IPR000885  Fibrillar collagen, C-terminal
 IPR001007  VWFC domain
 IPR008160  Collagen triple helix repeat
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0030903 notochord development IGI
 cellular_componentGO:0005581 collagen trimer ISS
 molecular_functionGO:0005201 extracellular matrix structural constituent IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Extracellular matrix organization
Collagen biosynthesis and modifying enzymes
Signaling by PDGF
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
NCAM1 interactions
MET activates PTK2 signaling
Collagen chain trimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000135 notochord notochord deformed , abnormal
notochord physical object quality , abnormal
Show

 ZFA:0000155 somite somite shape , abnormal
Show

 ZFA:0001094 whole organism whole organism curved ventral , abnormal
whole organism anterior-posterior axis curved ventral , abnormal
whole organism decreased length , abnormal
Show

 ZFA:0001115 trunk trunk shortened , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved ventral , abnormal
Show

 ZFA:0001189 vertebra vertebra fused with vertebra , abnormal
Show

 ZFA:0005110 thoracic duct thoracic duct malformed , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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