ENSMUSG00000027966


Mus musculus

Features
Gene ID: ENSMUSG00000027966
  
Biological name :Col11a1
  
Synonyms : Col11a1 / Collagen alpha-1(XI) chain / Q61245
  
Possible biological names infered from orthology : collagen type XI alpha 1 chain / P12107
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F3
Gene start: 114030540
Gene end: 114220718
  
Corresponding Affymetrix probe sets: 10495449 (MoGene1.0st)   1418599_at (Mouse Genome 430 2.0 Array)   1449154_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148798
Ensembl peptide - ENSMUSP00000089793
Ensembl peptide - ENSMUSP00000121027
Ensembl peptide - ENSMUSP00000138879
NCBI entrez gene - 12814     See in Manteia.
MGI - MGI:88446
RefSeq - XM_017319445
RefSeq - NM_007729
RefSeq - XM_006500969
RefSeq - XM_006500970
RefSeq - XM_006500971
RefSeq Peptide - NP_031755
swissprot - V9GWX8
swissprot - E9PVT8
swissprot - A0A1D5RMJ0
swissprot - Q61245
Ensembl - ENSMUSG00000027966
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 col11a1aENSDARG00000026165Danio rerio
 col11a1bENSDARG00000009014Danio rerio
 COL11A1ENSGALG00000005180Gallus gallus
 P12107ENSG00000060718Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Col5a1 / O88207 / Collagen alpha-1(V) chain / P20908* / collagen type V alpha 1 chain*ENSMUSG0000002683774
Q64739 / Col11a2 / Collagen alpha-2(XI) chain / P13942* / collagen type XI alpha 2 chain*ENSMUSG0000002433061
Col5a3 / collagen, type V, alpha 3 / P25940* / collagen type V alpha 3 chain*ENSMUSG0000000409855
Col2a1 / P28481 / Collagen alpha-1(II) chain Collagen alpha-1(II) chain Chondrocalcin / P02458* / collagen type II alpha 1 chain*ENSMUSG0000002248337
Col1a1 / P11087 / Collagen alpha-1(I) chain / P02452* / collagen type I alpha 1 chain*ENSMUSG0000000150636
Col5a2 / Q3U962 / Collagen alpha-2(V) chain / P05997* / collagen type V alpha 2 chain*ENSMUSG0000002604236
Col3a1 / P08121 / Collagen alpha-1(III) chain / P02461* / collagen type III alpha 1 chain*ENSMUSG0000002604335
Col1a2 / Q01149 / Collagen alpha-2(I) chain / P08123* / collagen type I alpha 2 chain*ENSMUSG0000002966134
Q5QNQ9 / Col27a1 / Collagen alpha-1(XXVII) chain / Q8IZC6* / collagen type XXVII alpha 1 chain*ENSMUSG0000004567234
Q30D77 / Col24a1 / Collagen alpha-1(XXIV) chain / Q17RW2* / collagen type XXIV alpha 1 chain*ENSMUSG0000002819731


Protein motifs (from Interpro)
Interpro ID Name
 IPR000885  Fibrillar collagen, C-terminal
 IPR001791  Laminin G domain
 IPR008160  Collagen triple helix repeat
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR016133  Insect cysteine-rich antifreeze protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001502 cartilage condensation IMP
 biological_processGO:0001503 ossification IEA
 biological_processGO:0002063 chondrocyte development IMP
 biological_processGO:0003007 heart morphogenesis IGI
 biological_processGO:0006029 proteoglycan metabolic process IMP
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0030199 collagen fibril organization IMP
 biological_processGO:0035987 endodermal cell differentiation IEA
 biological_processGO:0035989 tendon development IMP
 biological_processGO:0042472 inner ear morphogenesis IMP
 biological_processGO:0048704 embryonic skeletal system morphogenesis IMP
 biological_processGO:0048705 skeletal system morphogenesis IMP
 biological_processGO:0050910 detection of mechanical stimulus involved in sensory perception of sound IEA
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0055010 ventricular cardiac muscle tissue morphogenesis IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005592 collagen type XI trimer IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005201 extracellular matrix structural constituent IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Collagen biosynthesis and modifying enzymes
Assembly of collagen fibrils and other multimeric structures
Non-integrin membrane-ECM interactions
MET activates PTK2 signaling
Collagen chain trimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000065 abnormal bone marrow cavities "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000133 abnormal long bone metaphysis morphology "malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Col11a1cho/Col11a1+
Genetic Background: involves: C57BL/6Fr

 MP:0000435 shortened head "reduced anterior-posterior length of the head" [J:42035]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col11a1cho/Col11a1+
Genetic Background: involves: C57BL/6Fr

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003120 abnormal tracheal cartilage "any structural anomaly of the cartilaginous structures that support the trachea" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:97123]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003560 osteoarthritis "a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more joints" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95374]
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Allelic Composition: Col11a1cho/Col11a1+
Genetic Background: involves: C57BL/6Fr

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004214 abnormal long bone diaphysis morphology "any structural anomaly of the main or mid section (shaft) of a long bone" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004397 absent cochlear inner hair cells "absence of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004403 absent cochlear outer hair cells "absence of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006395 abnormal epiphyseal plate morphology "any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352]
Show

Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006429 abnormal hyaline cartilage morphology "any structural anomaly of the bluish-white, glassy, translucent nonvascular, resilient, flexible connective tissue; found primarily in articular cartilage, costal cartilages, the nasal septum, the larynx, and the trachea" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006432 abnormal costal cartilage morphology "any structural anomaly of the nonvascular, resilient, flexible connective tissue that connects the end of a true rib to the sternum or the end of a false rib with the costal cartilage above" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008069 abnormal joint mobility "anomaly in the ability to move joints in a full range of motion and with ease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col11a1cho/Col11a1+
Genetic Background: involves: C57BL/6Fr

 MP:0008151 increased diameter of long bones "increased width of the cross-sectional distance that extends from one lateral edge of a long bone, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008272 abnormal endochondral bone ossification "anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008736 micromelia "disproportionately short or small limbs" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009908 protruding tongue "the tongue extends out beyond the oral cavity past the lips; may be due to paralysis, oral cavity size, tongue hypoplasia or dysfunction of the hypoglossal nerve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011966 abnormal auditory brainstem response waveform shape "any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0020137 decreased bone mineralization "decrease in the rate at which minerals are deposited into bone" []
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0030026 small Meckel s cartilage "reduced size of the cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible and gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [MGI:anna]
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Allelic Composition: Six5tm1Rdd/Six5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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