ENSMUSG00000026837


Mus musculus

Features
Gene ID: ENSMUSG00000026837
  
Biological name :Col5a1
  
Synonyms : Col5a1 / Collagen alpha-1(V) chain / O88207
  
Possible biological names infered from orthology : collagen type V alpha 1 chain / P20908
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A3
Gene start: 27886425
Gene end: 28039514
  
Corresponding Affymetrix probe sets: 10470462 (MoGene1.0st)   1416740_at (Mouse Genome 430 2.0 Array)   1416741_at (Mouse Genome 430 2.0 Array)   1434479_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028280
Ensembl peptide - ENSMUSP00000123532
NCBI entrez gene - 12831     See in Manteia.
MGI - MGI:88457
RefSeq - NM_015734
RefSeq - XM_006497644
RefSeq Peptide - NP_056549
swissprot - B1AWB9
swissprot - A3KGE7
swissprot - O88207
Ensembl - ENSMUSG00000026837
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 col5a1ENSDARG00000012593Danio rerio
 COL5A1ENSGALG00000002546Gallus gallus
 COL5A1ENSG00000130635Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q61245 / Col11a1 / Collagen alpha-1(XI) chain / P12107* / collagen type XI alpha 1 chain*ENSMUSG0000002796673
Q64739 / Col11a2 / Collagen alpha-2(XI) chain / P13942* / collagen type XI alpha 2 chain*ENSMUSG0000002433063
Col5a3 / collagen, type V, alpha 3 / P25940* / collagen type V alpha 3 chain*ENSMUSG0000000409856
Col2a1 / P28481 / Collagen alpha-1(II) chain Collagen alpha-1(II) chain Chondrocalcin / P02458* / collagen type II alpha 1 chain*ENSMUSG0000002248337
Col1a1 / P11087 / Collagen alpha-1(I) chain / P02452* / collagen type I alpha 1 chain*ENSMUSG0000000150636
Col3a1 / P08121 / Collagen alpha-1(III) chain / P02461* / collagen type III alpha 1 chain*ENSMUSG0000002604335
Col5a2 / Q3U962 / Collagen alpha-2(V) chain / P05997* / collagen type V alpha 2 chain*ENSMUSG0000002604235
Q5QNQ9 / Col27a1 / Collagen alpha-1(XXVII) chain / Q8IZC6* / collagen type XXVII alpha 1 chain*ENSMUSG0000004567234
Col1a2 / Q01149 / Collagen alpha-2(I) chain / P08123* / collagen type I alpha 2 chain*ENSMUSG0000002966134
Q30D77 / Col24a1 / Collagen alpha-1(XXIV) chain / Q17RW2* / collagen type XXIV alpha 1 chain*ENSMUSG0000002819732


Protein motifs (from Interpro)
Interpro ID Name
 IPR000885  Fibrillar collagen, C-terminal
 IPR001791  Laminin G domain
 IPR008160  Collagen triple helix repeat
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR016133  Insect cysteine-rich antifreeze protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0003007 heart morphogenesis IGI
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0030199 collagen fibril organization ISO
 biological_processGO:0032964 collagen biosynthetic process ISO
 biological_processGO:0035313 wound healing, spreading of epidermal cells ISO
 biological_processGO:0035989 tendon development IMP
 biological_processGO:0043588 skin development IEA
 biological_processGO:0045112 integrin biosynthetic process ISO
 biological_processGO:0048592 eye morphogenesis ISO
 biological_processGO:0051128 regulation of cellular component organization IMP
 biological_processGO:0097435 supramolecular fiber organization ISO
 biological_processGO:1903225 negative regulation of endodermal cell differentiation ISO
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005588 collagen type V trimer ISO
 cellular_componentGO:0005604 basement membrane IDA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0031012 extracellular matrix HDA
 molecular_functionGO:0005201 extracellular matrix structural constituent IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0043394 proteoglycan binding ISO
 molecular_functionGO:0048407 platelet-derived growth factor binding ISO


Pathways (from Reactome)
Pathway description
Collagen degradation
Extracellular matrix organization
Collagen biosynthesis and modifying enzymes
Signaling by PDGF
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
NCAM1 interactions
MET activates PTK2 signaling
Collagen chain trimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000272 abnormal aorta morphology "structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pycardtm1Flv/Pycardtm1Flv
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pycardtm1Flv/Pycardtm1Flv
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001243 abnormal dermal layer morphology "malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Pycardtm1Flv/Pycardtm1Flv
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk1tm1Hed/Mapk1tm1Hed,Mapk3tm1Gpg/Mapk3tm1Gpg,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
Show

Allelic Composition: Mapk1tm1Hed/Mapk1tm1Hed,Mapk3tm1Gpg/Mapk3tm1Gpg,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Pycardtm1Flv/Pycardtm1Flv
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003089 reduced skin tensile strength "reduction in the normal maximum tension the skin can withstand without tearing" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:48068]
Show

Allelic Composition: Pycardtm1Flv/Pycardtm1Flv
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0003092 reduced corneal stroma thickness "reduced width of the lamellated connective tissue layer of the cornea" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:81616]
Show

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003093 abnormal anterior stroma morphology "structural anomaly of the anterior segment of the lamellated connective tissue layer of the cornea" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:81616, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003094 abnormal posterior stroma morphology "structural anomaly of the posterior segment of the lamellated connective tissue layer of the cornea" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:81616]
Show

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003096 increased corneal light-scattering "anomaly in the normal transmission of light through the cornea; light is reflected or absorbed instead; often due to anomalies in the arrangement of lamella in the corneal stroma" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator, J:81616]
Show

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005300 abnormal corneal stroma morphology "structural anomaly of the lamellated connective tissue of the cornea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008438 abnormal cutaneous collagen fibril morphology "any structural anomaly of the connective tissue bundles in the extracellular matrix of skin tissue that are composed of collagen, and play a role in skin strength and elasticity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapk1tm1Hed/Mapk1tm1Hed,Mapk3tm1Gpg/Mapk3tm1Gpg,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Col5a1tm1Rjw/Col5a1+
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Mapk1tm1Hed/Mapk1tm1Hed,Mapk3tm1Gpg/Mapk3tm1Gpg,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011650 abnormal corneal stroma collagen fibril morphology "any structural anomaly of the connective tissue bundles in the extracellular matrix of corneal stroma that are composed of collagen, and play a role in tissue strength and elasticity" [MGI:csmith]
Show

Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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