ENSMUSG00000028597


Mus musculus

Features
Gene ID: ENSMUSG00000028597
  
Biological name :Gpx7
  
Synonyms : Glutathione peroxidase 7 / Gpx7 / Q99LJ6
  
Possible biological names infered from orthology : Q96SL4
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C7
Gene start: 108400390
Gene end: 108406961
  
Corresponding Affymetrix probe sets: 10515007 (MoGene1.0st)   1417836_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030332
Ensembl peptide - ENSMUSP00000139335
NCBI entrez gene - 67305     See in Manteia.
MGI - MGI:1914555
RefSeq - NM_024198
RefSeq Peptide - NP_077160
swissprot - Q3TNK3
swissprot - Q99LJ6
swissprot - V9GXV4
Ensembl - ENSMUSG00000028597
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpx7ENSDARG00000091511Danio rerio
 GPX7ENSGALG00000010633Gallus gallus
 GPX7ENSG00000116157Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gpx8 / Q9D7B7 / Probable glutathione peroxidase 8 / Q8TED1* / glutathione peroxidase 8 (putative)*ENSMUSG0000002176047
Gpx4 / O70325 / Phospholipid hydroperoxide glutathione peroxidase, mitochondrial / P36969* / glutathione peroxidase 4*ENSMUSG0000007570638
Gpx1 / P11352 / Mus musculus glutathione peroxidase 1 (Gpx1), transcript variant 2, mRNA. / P07203* / glutathione peroxidase 1*ENSMUSG0000006385636
Gpx6 / Q91WR8 / Glutathione peroxidase 6 / P59796*ENSMUSG0000000434134
Gpx5 / P21765 / Epididymal secretory glutathione peroxidase / O75715* / glutathione peroxidase 5*ENSMUSG0000000434432
Gpx3 / P46412 / Glutathione peroxidase 3 / P22352*ENSMUSG0000001833932
Gpx2 / glutathione peroxidase 2 / P18283*ENSMUSG0000004280831


Protein motifs (from Interpro)
Interpro ID Name
 IPR000889  Glutathione peroxidase
 IPR013376  Glutathione peroxidase Gpx7, putative
 IPR029759  Glutathione peroxidase active site
 IPR029760  Glutathione peroxidase conserved site
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 molecular_functionGO:0004096 catalase activity IEA
 molecular_functionGO:0004601 peroxidase activity ISO
 molecular_functionGO:0004602 glutathione peroxidase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001864 vasculitis "inflammation of a blood or lymph vessel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
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Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008406 increased cellular sensitivity to hydrogen peroxide "greater incidence of cell death following exposure to hydrogen peroxide" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008412 increased cellular sensitivity to oxidative stress "greater incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0010318 increased salivary gland tumor incidence "greater than the expected number of neoplams in the salivary gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0010799 stomach mucosa hyperplasia "overdevelopment or increased size, usually due to an increase in the number of cells, of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Msx1tm2.1(cre/ERT2)Bero/Msx1tm2.1(cre/ERT2)Bero,Msx2tm1Bero/Msx2tm1Bero
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025130 P4hb / P09103 / prolyl 4-hydroxylase, beta polypeptide / P07237* / prolyl 4-hydroxylase subunit beta*  / reaction
 ENSMUSG00000021831 Ero1l / Q8R180 / ERO1-like protein alpha / ERO1A* / Q96HE7* / endoplasmic reticulum oxidoreductase 1 alpha*  / complex






 

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