ENSG00000116157


Homo sapiens

Features
Gene ID: ENSG00000116157
  
Biological name :GPX7
  
Synonyms : glutathione peroxidase 7 / GPX7 / Q96SL4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p32.3
Gene start: 52602372
Gene end: 52609051
  
Corresponding Affymetrix probe sets: 213170_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000354677
NCBI entrez gene - 2882     See in Manteia.
OMIM - 615784
RefSeq - NM_015696
RefSeq Peptide - NP_056511
swissprot - Q96SL4
Ensembl - ENSG00000116157
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpx7ENSDARG00000091511Danio rerio
 GPX7ENSGALG00000010633Gallus gallus
 Gpx7ENSMUSG00000028597Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GPX8 / Q8TED1 / glutathione peroxidase 8 (putative)ENSG0000016429451
GPX4 / P36969 / glutathione peroxidase 4ENSG0000016746836
GPX1 / P07203 / glutathione peroxidase 1ENSG0000023327635
GPX5 / O75715 / glutathione peroxidase 5ENSG0000022458633
GPX6 / P59796 / glutathione peroxidase 6ENSG0000019870430
GPX2 / P18283 / glutathione peroxidase 2ENSG0000017615330
GPX3 / P22352 / glutathione peroxidase 3ENSG0000021144529


Protein motifs (from Interpro)
Interpro ID Name
 IPR000889  Glutathione peroxidase
 IPR013376  Glutathione peroxidase Gpx7, putative
 IPR029759  Glutathione peroxidase active site
 IPR029760  Glutathione peroxidase conserved site
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0034599 cellular response to oxidative stress TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 molecular_functionGO:0004096 catalase activity IDA
 molecular_functionGO:0004601 peroxidase activity EXP
 molecular_functionGO:0004602 glutathione peroxidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000185624 P4HB / P07237 / prolyl 4-hydroxylase subunit beta  / reaction
 ENSG00000197930 ERO1A / Q96HE7 / endoplasmic reticulum oxidoreductase 1 alpha  / complex






 

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